Non-Hodgkin's lymphoma can occur anywhere in the human body. A diffuse extensive peritoneal lesion is uncommon and rare. Diffuse large B-cell most common histological type of extranodal lymphomatosis. case isolated lymphomatosis presented. 23-year-old female patient N. presented with decreased appetite, bloating, pain, abdominal enlargement. The symptoms persisted for 4 months. Recently, she reported a fever (38.4°C), sweating at night, body weight. On physical examination, abdomen was...

Metastases of malignant neoplasms into the penis from various primary locations are extremely rare. These lesions due to disseminated tumor. In most cases, tumors located in genitourinary system (75%), gastrointestinal tract (21%), and lungs (7%). The prognosis is poor, with patients dying within a year diagnosis. purpose article present rare case metastatic lesion adrenocortical cancer. A 59-year-old patient stage III right adrenal tumor pT3N0M0 had undergone an adrenalectomy. Histological...

Background. According to the literature, role of combined positron-emission and X-ray computed tomography (PET/CT) in diagnosing primary adrenal tumors (AT) remains limited due both frequency these neoplasms availability method. Various research is required assess diagnostic resources PET/CT with 18-fluorodeoxyglucose (18F-FDG). Aim. To evaluate clinical 18F-FDG diagnosis malignancies (PAM). Materials methods. The study included 9 patients, 5 males 4 females aged 44–76, a median age 59.3...

Background. Agenesis of the corpus callosum (ACC) is total or partial absence CC, one most common congenital brain malformations, with an incidence rate 1.4 cases per 10,000 live births. Aim. To describe clinical and diagnostic features 4 patients ACC. Materials methods. Four ACC aged 11, 12, 13, 50 years were managed, whom 3 males, 1 was a 13-year-old girl. All underwent neurological examination, which assessed cognitive mental disorders electroencephalography. Patients magnetic resonance...

Isolated splenic metastases from colorectal cancer after radical surgical treatment are quite rare. This frequency of is explained by the anatomical, functional and immunological characteristics spleen. The literature usually describes single clinical cases followed accompanied systematic analysis discussion. Most asymptomatic accidentally diagnosed, during different types imaging tests, including increased levels tumor markers. progression free survival was 3 144 months primary in most...

Background. Malignant priapism is a painful lesion and persistent erection of the penis due to metastatic infiltration by neoplasm. Secondary penile malignancy, as consequence disease, rare event. This indicates progression main disease an unfavorable outcome. Most cases cancer are from urogenital region: prostate 33%, urinary bladder 30%, kidneys 8% gastrointestinal tract 8%.
 Aim. To describe case malignant refractory in patient.
 Materials methods. A 49-year-old patient with...

Background. Radiation-induced malignancies are one of the long-term complications radiation therapy, which is widely used to treat some tumors. The latency period before a second tumor develops varies from 3 60 years. Epithelial tumors and hemoblastoses occur after low-dose therapy sarcomas high-dose therapy.
 Aim. To present case radiation-induced soft tissue angiosarcoma neck cure Hodgkin's disease.
 Materials methods. A 41-year-old patient with nodular lymphoma lymphoid...

Background. Esthesioneyroblastoma is a rare malignant tumor arising from olfactory neuroepithelium of the nasal cavity. It an aggressive local tumor. accounts for 3 to 6% cases and sinus cancer. Occurs at any age. Due rarity disease, there are no uniform standards treatment. A multimodal interdisciplinary approach recommended.
 Aim. To present results retrospective study patients with esthesioneuroblastoma.
 Materials methods. The was carried out using database departments...

Background. Subacute thyroiditis is a rare inflammatory thyroid disease presumably associated with viral infection, including COVID-19. It accounts for about 5% of all diseases.
 Materials and methods. A clinical case de Quervain's subacute in patient diffuse hypermetabolic 18-fluorodeoxyglucose uptake by the gland presented.
 Results. 61-year-old no history disorders 3 weeks after COVID-19 experienced fever evenings (37.839.8C). He had moderate pain radiation to jaw, severe...

Background. Primary hyperparathyroidism is a common endocrinological disease caused mainly by parathyroid adenoma. The main treatment method surgery (parathyroidectomy). Therefore, the exact determination of adenoma localization crucial.
 Aim. To evaluate current possibilities multimodal diagnosis adenomas.
 Materials and methods. A retrospective analysis 49 patients with primary aged 24 to 82 (median 57.9 years) was performed. Modern radionuclide hybrid technologies were used for...

The article presents a literature review considering epidemiological aspects of secondary cancer the thyroid gland. authors’ clinical observation renal cell carcinoma metastasis into gland with tumor thrombus internal jugular vein is described. authors emphasize necessity complex diagnostics and treatment carcinoma.

Positron emission tomography combined with computer (PET/CT) is considered as a noninvasive method for evaluation in lung cancer. SUVmax provides information on biological aggressiveness, key pathological features and potential of tumor spread. However, standardized generally accepted criteria determining malignant benign lymph nodes do not exist, which common problem molecular diagnostics physicians generates clinical demand, since the standardization these has to improve diagnostic...

Renal cell cancer metastases without evidence of a primary tumor are extremely rare. These variants usually showed as spontaneous description single clinical cases.
 Aim.This contribution is follow-up synchronous renal unknown site.
 Results.A 52-year-old patient U. with history increased blood pressure, up to 170/100 mmHg for the last 5 years, who had undergone many instrumental examinations, including ultrasound examination, because this disease. The computed tomography abdomen...

Background. Lung cancer is still the leading cause of morbidity and mortality among both men women. At same time, non-small cell lung (NSCLC) accounts for 85% all cases malignant tumors. Historically, treatment locally advanced metastatic was consisted systemic cytotoxic therapy. The main aim to destroy tumor cells, reduce severity disease manifestations, improve quality life prolong survival. Recent discovery mutations in epidermal growth factor receptor (EGFR) gene ALK translocations or...

Introduction. Pulmonary toxicity induced by bleomycin is a dangerous complication of polychemotherapy in patients with germ cell tumors. It occurs frequency up to 46%, and 14% cases it fatal.
 Aim. To present pulmonary during the inclusion for testicular tumors.
 Materials Methods. Two aged 43 33 years old tumors were under observation after orchifuniculectomy who underwent chemotherapy according BER scheme (bleomycin + etoposide cisplatin) steady-state mode 4 6 cycles...

Rituximab is a chimeric monoclonal antibody against CD20+ lymphocytes used to treat non-Hodgkin lymphoma, hematological and autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, thrombocytopenic purpura, hemolytic anemia, multiple sclerosis. The safety of the drug critical choice treatment. Rituximab-associated interstitial lung disease rare.
 Objective. To describe case pneumonitis induced by rituximab in monotherapy at end maintenance therapy.
 Materials...

The aim of this work was to present the results a retrospective study 35 patients with morphologically diagnosed diffuse B-cell large cell lymphoma bone marrow damage from 22 82 years old, median 63 years. There were 27 men and 8 women. After histological confirmation, all performed positron emission tomography combined computed 18F-fluorodeoxyglucose (FDG PET/CT) followed by trepanobiopsy. Specific lesions detected in 100% cases PET/CT 68.6% Diffuse 24 (68.6%) cases, focal – 10 (28.6%) 1...

Introduction. Brain metastases can occur in almost all gynecological malignancies and, despite modern therapeutic options, have a poor prognosis. from vulvar cancer are considered to be rare. In the literature, reports on these cases identity character. The aim is show clinical observation of patient with brain metastases. Results. Patient S., 60 years old, stage I р T1N0M0 underwent vulvectomy January 2018. During histological study subepithelial layers were areas kraurosis growth squamous...

Introduction. Papillary thyroid cancer (PTC) usually metastasizes into the central and lateral lymph nodes (LNs) of neck. Metastases retropharyngeal parapharyngeal LNs are rare. Their presence attests to aggressive PTC. The study objective is describe a rare case metastases papillary radioiodine-refractory PTC LN. Clinical . In 2015, female patient K., 40 years old, underwent thyroidectomy due Histological examination verified with growth through capsule ingrowth surrounding tissues muscles....

Background. Breast cancer is the leading cause of death in women. Distant metastases different organs, including thyroid gland, are still an urgent problem. very rare clinical practice. Nevertheless, accumulated and surgical experience treatment has shown that breast second most common primary tumor, to gland metastases, after kidney cancer.
 Aim. Present observations synchronous from Materials methods. We observed two patients, aged 55 72 years, suffering metastatic with simultaneous...

Background. Lung cancer (LC) occupies a leading position among malignant tumors in the world, it accounts for 11.4% of total neoplasms. In 2020, there were 2 206 771 new cases LC and 1 796 144 deaths worldwide. Among histological variants, small cell (SCLC) has most unfavorable outcomes. This variant is considered highly sensitive to chemotherapy. Despite some successes treatment this disease, results remain problematical. recent years, use immune checkpoint inhibitors provided significant...