A5034635018- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Protein purification and stability
- Glycosylation and Glycoproteins Research
- Antimicrobial Peptides and Activities
- Advanced Biosensing Techniques and Applications
- Biochemical and Structural Characterization
- Nicotinic Acetylcholine Receptors Study
Princeton University
2022
Eon Corporation (United States)
2021
Biological weapons have been used for thousands of years, but recent advances in synthesis technologies made peptide and protein toxin production more accessible pose a threat to biosecurity worldwide. Natural toxins such as conotoxins, certain hemolytic compounds, enterotoxins are agents that can be synthesized an environment with weak measures rudimentarily weaponized limited use against smaller targets lethal or nonlethal effects. Technological changing the landscape around biological...
Detailed description of the mechanism action therapeutic antibodies is essential for functional characterization and future optimization potential clinical agents. We recently developed KD035, a fully human antibody targeting vascular endothelial growth factor receptor 2 (VEGFR2). KD035 blocked VEGF-A, VEGF-C-mediated VEGFR2 activation, as demonstrated by in vitro binding competition assays cellular assays. Here, we report computational model complex between variable fragment (KD035(Fv))...