A5038358362- Silkworms and Sericulture Research
- Viral Infectious Diseases and Gene Expression in Insects
- Insect Utilization and Effects
- Insect Resistance and Genetics
- Biochemical and Structural Characterization
- Enzyme Production and Characterization
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Amino Acid Enzymes and Metabolism
- Fire effects on ecosystems
- Vector-Borne Animal Diseases
- Click Chemistry and Applications
- Glycosylation and Glycoproteins Research
- Silk-based biomaterials and applications
- Insect-Plant Interactions and Control
- Fungal and yeast genetics research
- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- Viral Infections and Vectors
- Force Microscopy Techniques and Applications
- Venomous Animal Envenomation and Studies
- Polyamine Metabolism and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diatoms and Algae Research
- Evolution and Genetic Dynamics
MRC University of Glasgow Centre for Virus Research
2020
Google (United States)
2017
Indian Institute of Science Bangalore
2012
University of Cambridge
2012
KU Leuven
2010-2012
Most homodimeric proteins have symmetric structure. Although symmetry is known to confer structural and functional advantage, asymmetric organization also observed. Using a non-redundant dataset of 223 high-resolution crystal structures biologically relevant homodimers, we address questions on the prevalence significance asymmetry. We used two measures quantify global interface asymmetry, assess correlation several molecular parameters with identified rare cases (11/223) homodimers...
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found countries surrounding Mediterranean. TOSV an important cause of seasonal acute meningitis and encephalitis within its range. Here, we determined full sequence strain 1500590, lineage A obtained from infected patient (Marseille, 2007) used this combination with other information to construct functional cDNA plasmids encoding viral L, M, S antigenomic sequences under control T7 RNA promoter recover...
Sex chromosomal dose difference between sexes is often normalized by a gene regulatory mechanism called dosage compensation (DC). Studies indicate that DC mechanisms are generally effective in XY rather than ZW systems. However, studies lepidopterans (ZW system) gave bewildering results. In Manduca sexta , was complete and Plodia interpunctella it incomplete. Heliconius species, found to be partly domesticated silkmoth Bombyx mori have yielded contradictory results thus far, showing...
Neuroserpin, a clade of serine proteinase inhibitors (serpins) is selective inhibitor tissue-type plasminogen activator (tPA) and usually has more than 220 residues. The crystal structure native human neuroserpin been reported by Sayaka et al., [17] at 2.1 Å resolution. fold composed five stranded β-sheet A mobile helical reactive center loop (RCL). also contains an omega (Ω-loop), which contributes to the inhibition tPA helix 'F' that plays important role in folding, complex formation...
Comparison of a newly found enzyme with its structural homologues results in the prediction probable regulatory binding sites. Since serine racemases are to be promising targets for treatment disorders related NMDAR dysfunction, identification similarities between and their might provide insights rational drug design. In this study, we aim determine mammalian bacterial biosynthetic threonine deaminase.