A5085609793- Viral Infections and Vectors
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Nicotinic Acetylcholine Receptors Study
- SARS-CoV-2 detection and testing
- Receptor Mechanisms and Signaling
- Research on Leishmaniasis Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Fire effects on ecosystems
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Advanced Fluorescence Microscopy Techniques
- Bacterial biofilms and quorum sensing
- Plant Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
MRC University of Glasgow Centre for Virus Research
2019-2024
University of Glasgow
2020
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and economic devastation. In response, many laboratories have redirected attention SARS-CoV-2, meaning there is an urgent need for tools that can be used in unaccustomed working with coronaviruses. Here we report range SARS-CoV-2 research. First, describe facile single plasmid reverse...
Toscana virus (TOSV) ( Bunyavirales , Phenuiviridae Phlebovirus phlebovirus ) and other related human pathogenic arboviruses are transmitted by phlebotomine sand flies. TOSV has been reported in nations bordering the Mediterranean Sea among regions. Infection can result febrile illness as well meningitis encephalitis. Understanding vector-arbovirus interactions is crucial to improving our knowledge of how spread, this context, immune responses that control viral replication play a...
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, order Bunyavirales, found countries surrounding Mediterranean. TOSV an important cause of seasonal acute meningitis and encephalitis within its range. Here, we determined full sequence strain 1500590, lineage A obtained from infected patient (Marseille, 2007) used this combination with other information to construct functional cDNA plasmids encoding viral L, M, S antigenomic sequences under control T7 RNA promoter recover...
In this study, we identified and assembled a strain of American nodavirus (ANV) in the Phlebotomus papatasi-derived PP9ad cell line. This most closely resembles Flock House virus ANV Drosophila melanogaster S2/S2R Through small RNA sequencing analysis, demonstrate that replication cells is primarily targeted by exogenous interfering (exo-siRNA) pathway, with minimal engagement from PIWI-interacting (piRNA) pathway. mosquitoes such as Aedes Culex, PIWI pathway expanded specialised, which...
Abstract Fungal diseases are responsible for the deaths of over 1.5 million people worldwide annually. Antifungal peptides represent a useful source antifungals with novel mechanisms‐of‐action, and potentially provide new methods overcoming resistance. Here we investigate mode‐of‐action small, rationally designed synthetic antifungal peptide PAF26 using model fungus Neurospora crassa . show that cell killing activity is dependent on extracellular Ca 2+ presence fully functioning fungal...
Toscana virus (TOSV) is a Phlebovirus in the Phenuiviridae family, found countries surrounding Mediterranean. It unusual within genus for exhibiting tropism central nervous system: TOSV one of top causes seasonal acute meningitis/encephalitis its range. However, little progress has been made study TOSV, largely due to lack reliable reverse genetics system. We used RNA sequencing determine sequence strain 1500590, lineage A obtained from an infected patient (Marseille, 2007). This data was...
ABSTRACT Fungal diseases are responsible for the deaths of over 1.5 million people worldwide annually. Antifungal peptides represent a useful source antifungals with novel mechanisms-of-action, and potentially provide new methods overcoming resistance. Here we investigate mode-of-action small, rationally designed synthetic antifungal peptide PAF26 using model fungus Neurospora crassa . show that cell killing activity is dependent on extracellular Ca 2+ presence fully functioning fungal...