A5069061469- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Venomous Animal Envenomation and Studies
- Virology and Viral Diseases
- Fashion and Cultural Textiles
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- SARS-CoV-2 detection and testing
University of Leeds
2016-2022
MRC University of Glasgow Centre for Virus Research
2021-2022
Medical Research Council
2022
University of Glasgow
2016-2020
University of Cambridge
2020
Highlights•Mosquito bites enhance virus replication and dissemination increase host mortality•Neutrophil-driven inflammation retains in skin to drive macrophage recruitment•Recruited resident myeloid cells become infected replicate virus•Blocking leukocyte recruitment bite site inhibits viral infectionSummaryAedes aegypti mosquitoes are responsible for transmitting many medically important viruses such as those that cause Zika dengue. The inoculation of into mosquito sites is an common stage...
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and economic devastation. In response, many laboratories have redirected attention SARS-CoV-2, meaning there is an urgent need for tools that can be used in unaccustomed working with coronaviruses. Here we report range SARS-CoV-2 research. First, describe facile single plasmid reverse...
Viruses transmitted by Aedes mosquitoes are an increasingly important global cause of disease. Defining common determinants host susceptibility to this large group heterogenous pathogens is key for informing the rational design panviral medicines. Infection vertebrate with these viruses enhanced mosquito saliva, a complex mixture salivary-gland-derived factors and microbiota. We show that enhancement infection saliva was dependent on vascular function independent most antisaliva immune...
Arthropod-borne viruses (arboviruses) are important human pathogens for which there no specific antiviral medicines. The abundance of genetically distinct arbovirus species, coupled with the unpredictable nature their outbreaks, has made development virus-specific treatments challenging. Instead, we have defined and targeted a key aspect host innate immune response to virus at arthropod bite that is common all infections, potentially circumventing need therapies. Using mouse models skin...
Abstract Dabie bandavirus (previously severe fever with thrombocytopenia syndrome virus; SFTSV), is an emerging tick-borne bunyavirus responsible for (SFTS), a disease high case fatality that characterized by fever, thrombocytopenia, and potentially lethal hemorrhagic manifestations. Currently, neither effective therapeutic strategies nor approved vaccines exist SFTS. Therefore, there remains pressing need to better understand the pathogenesis of identify ameliorate SFTS outcomes. Using type...
Mosquitoes can pass disease to humans when they bite, which includes infections caused by viruses, known as arboviruses. These viruses infect many millions of people each year and include that cause diseases such Zika, dengue chikungunya. Most are usually found in the tropics, but a changing climate globalization means their range has spread at an alarming rate. Cumulatively these highly diverse genetic level up 90 human pathogens. It is hard predict nature, timing location outbreaks....
Summary Viruses transmitted by Aedes mosquitoes constitute an increasingly important global health burden. Defining common determinants of host susceptibility to this large group heterogenous pathogens are key for informing the rational design new pan-viral medicines. Infection vertebrate with these viruses is enhanced presence mosquito saliva, a complex mixture salivary gland-derived factors and microbiota. We show that enhancement infection saliva was dependent on vascular function...
Abstract Some free fatty acids derived from milk and vegetable oils are known to have potent antiviral antibacterial properties. However, therapeutic applications of short medium chain limited by physical characteristics such as immiscibility in aqueous solutions. We evaluated a novel proprietary formulation based on an emulsion caprylic acid, ViroSAL, for its ability inhibit range viral infections vitro vivo. In , ViroSAL inhibited the enveloped viruses Epstein-Barr, measles, herpes...
Abstract Arthropod-borne viruses (arboviruses) are important human pathogens for which there no specific antiviral medicines. The large number of genetically-distinct arbovirus species, coupled with the unpredictable nature their outbreaks, has made developing virus-specific anti-viral medicines challenging. Instead, we have defined and targeted a key aspect host innate immune response to virus at arthropod bite that is common all infections, potentially circumventing need therapies this...
Arboviruses constitute a major public health problem, in particular mosquito-borne arboviruses that continue to emerge and re-emerge. Arbovirus infection of mammals is enhanced by the presence mosquito bite at inoculation site, comparison virus experimentally administered needle absence bite. Inflammatory responses bites appear be key factor this enhancement. However, experimental saliva with inoculum needle, trauma, also has ability enhance viral infections. In study, we have studied...
Arboviruses constitute a major public health problem; in particular mosquito-borne arboviruses that continuously emerge and re-emerge. Arbovirus infection of mammals is enhanced by the presence mosquito-bite at inoculation site, or co-inoculation extracted mosquito saliva alongside virus, comparison to virus experimentally administered needle absence bite/saliva. Inflammatory responses elicited appear be key facilitating this enhancement. As such, we have studied mechanistic basis for these...