Natalia Cameron-Ruiz
A5001725374- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- RNA regulation and disease
- Virology and Viral Diseases
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
MRC University of Glasgow Centre for Virus Research
2021-2023
Medical Research Council
2021
The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the underlying cause Disease 2019 (COVID-19), has led to a worldwide pandemic causing substantial morbidity, mortality, and economic devastation. In response, many laboratories have redirected attention SARS-CoV-2, meaning there is an urgent need for tools that can be used in unaccustomed working with coronaviruses. Here we report range SARS-CoV-2 research. First, describe facile single plasmid reverse...
Inherited genetic factors can influence the severity of COVID-19, but molecular explanation underpinning a association is often unclear. Intracellular antiviral defenses inhibit replication viruses and reduce disease severity. To better understand relevant to we used interferon-stimulated gene (ISG) expression screening reveal that 2′-5′-oligoadenylate synthetase 1 (OAS1), through ribonuclease L, potently inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We show common...
Abstract Cross-species transmission of avian influenza A viruses (IAVs) into humans could represent the first step a future pandemic 1 . Multiple factors limiting spillover and adaptation IAVs in have been identified, but they are not sufficient to explain which virus lineages more likely cross species barrier 1,2 Here, we identified human BTN3A3 3 (butyrophilin subfamily member A3) as potent inhibitor IAVs. We determined that is constitutively expressed airways its antiviral activity...