A5040863410- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- T-cell and Retrovirus Studies
- Influenza Virus Research Studies
- Agriculture and Farm Safety
- Viral Infections and Immunology Research
- Prostate Cancer Treatment and Research
- Chronic Myeloid Leukemia Treatments
- Animal Virus Infections Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Virus-based gene therapy research
- Veterinary medicine and infectious diseases
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- Oral Health Pathology and Treatment
- Virology and Viral Diseases
- Neurofibromatosis and Schwannoma Cases
- Diabetic Foot Ulcer Assessment and Management
- Cerebrovascular and Carotid Artery Diseases
- Aluminum toxicity and tolerance in plants and animals
- Bipolar Disorder and Treatment
- Insect symbiosis and bacterial influences
- Cardiovascular and Diving-Related Complications
Medical University of Sofia
2021-2024
Université de Rouen Normandie
2024
National and Kapodistrian University of Athens
2024
Christ University
2024
Medical University of Lodz
2024
Queen Giovanna Hospital
2024
Military Medical Academy
1998-2023
NIHR Leeds Musculoskeletal Biomedical Research Unit
2021-2022
University of Leeds
2021-2022
Ministry of Agriculture, Food and Forestry
2020-2021
Viruses transmitted by Aedes mosquitoes are an increasingly important global cause of disease. Defining common determinants host susceptibility to this large group heterogenous pathogens is key for informing the rational design panviral medicines. Infection vertebrate with these viruses enhanced mosquito saliva, a complex mixture salivary-gland-derived factors and microbiota. We show that enhancement infection saliva was dependent on vascular function independent most antisaliva immune...
This paper tests the hypothesis that Culicoides (Diptera: Ceratopogonidae) species can be propagated by wind over long distances. Movement patterns of midges were inferred indirectly from spread bluetongue outbreaks between farms (using outbreak data 1999-2001 for Greece, Bulgaria and Turkey) then matched to concurrent patterns. The general methodology was determine trajectories each site based on horizontal vertical components European ReAnalysis-40 (ERA-40) dataset centre medium-range...
Improvements to sequencing protocols and the development of computational phylogenetics have opened up opportunities study rapid evolution RNA viruses in real time. In practical terms, these results can be combined with field data order reconstruct spatiotemporal scenarios that describe origin transmission pathways during an epidemic. case notifiable diseases, such as foot-and-mouth disease (FMD), analyses provide important insights into epidemiology outbreaks support control programmes....
1 The spread of vector-borne diseases into new areas, commonly attributed to environmental change or increased trade and travel, could be exacerbated if novel vector species in newly invaded areas infection beyond the range traditional vectors. 2 By analysing differential degree overlap between envelopes for bluetongue, a devastating livestock disease, its (Afro-Asian) potential (Palearctic) midge vectors, we have implicated latter recent dramatic northward this disease Europe. 3 bluetongue...
Infections of humans with the tick-borne Crimean–Congo hemorrhagic fever virus (CCHFV) can cause a severe case fatality rates up to 80%. Most are infected by tick bite, crushing ticks hand or unprotected contact blood viremic mammals. Next notified human CCHF cases, real distribution and situation in animals Southeastern Europe nearly unknown. Since domestic ruminants play crucial role life cycle vector transmission amplification virus, antibody prevalence those is good indicator for...
Abstract Surveillance of Culicoides (Diptera: Ceratopogonidae) biting midges was carried out between 2001 and 2003, at 119 sites within a 50 × 50‐km grid distributed across Bulgaria, using light trap collections around the time peak adult midge abundance. Sentinel ad hoc serum surveillance hosts susceptible to bluetongue infection 300 1999 2003. Following initial incursion virus 9 (BTV‐9) into Bourgas province in 1999, affecting 85 villages along southern border, further 76 were affected...
On March 15, 2010, a highly pathogenic avian influenza virus was isolated from the carcass of common buzzard (Buteo buteo) in Bulgaria. Phylogenetic analyses showed close genetic relationship with A (H5N1) clade 2.3.2.1 viruses wild birds Tyva Republic and Mongolia during 2009-2010. Designated A/common buzzard/Bulgaria/38WB/2010, this strain chickens but had low pathogenicity mice ferrets no molecular markers increased mammals. The establishment H5N1 subtype Europe would increase likelihood...
Objectives: The aim of our study was to characterize the neurological symptoms in Bulgarian patients with Wilson disease (WD), investigate genotype-phenotype correlations, and test whether there are differences phenotype between different ethnic origin. Patients Methods: A total 126 WD were included study. Detailed history, physical examination, laboratory investigation copper metabolism, slit-lamp abdominal ultrasound, magnetic resonance imaging/computed tomography brain, molecular genetic...
Ducks can shed and spread influenza A viruses (IAVs) while showing no disease signs. Our objective was to clarify the role of 'foie gras' ducks in circulation IAVs Bulgaria.Monthly avian surveillance conducted on 63 duck farms, 52 which were surveyed throughout study between November 2008 April 2012. Virologic serologic samples collected tested. During this time, wild bird at major bird-resting areas near Black Sea coast Danube River.The showed high isolation frequency low-pathogenicity...
The aim of this study is to compare the efficacy procalcitonin (PCT) and high-sensitive C-reactive protein (hsCRP) as diagnostic biomarkers in patients with diabetes mild-to-moderate diabetic foot infections. A total 119 (102 type 2 17 1 diabetes), mean age 60.29 ± 10.05 years, divided into 3 groups—diabetic ulcer (DFU) active infection (IDFU group, n = 41), DFU without clinical signs (non-IDFU 35), a control group (n 43). Infection severity was graded according International Working Group...
Hydrometra is the accumulation of fluid within uterine cavity.Hydrometra may be manifested alone or in combination with other manifestations reproductive pathology.The current paper presents a case study female pet rabbit.The rabbit was brought to clinic complaints gastrointestinal system.Initial symptoms had been resolved and for second time.Physical examination revealed an enlarged abdomen fluctuations soft-elastic texture; body temperature normal: 39.3°С; breathing heartbeat were...
This article outlines pathomorphologic findings of a study involving commercial mule ducks with confirmed influenza A H5N8 infections after series outbreaks in Bulgaria. Examinations were carried out performing necropsy on dead birds from three different age groups (up to 15, 20 30, and 40+ days age) fattened farms. Among all ages, gross lesions present as affecting the heart. Histologically, myocardium exhibited severe intermyofibrillar edema, moderate massive hemorrhages, degenerative...
Bulgaria has a unique geographic position in Europe, with two migratory wild bird routes, Via Pontica and Aristotelis, passing through the country. is second-largest migration route hundreds of thousands birds, representing more than 110 species, wintering lakes by Black Sea wetlands near Danube River. Aristotelis situated West along Strouma Mesta river valleys, it regional importance for Balkan Peninsula. In this study, we examined 2000 samples from birds orders Anseriformes, Ciconiiformes,...
Foot-and-mouth-disease is severe, highly contagious disease of cloven - hoofed animals that affects large animal livestock species and various wildlife species. Different countries has a different FMD status which require disparate approach defining the diagnostic control strategy. A variety new tests procedures was developed to improve laboratory diagnosis. The aim this study evaluate contemporary tools ability our detect virus or viral genome in field samples cell culture fluids using an...
Summary Affective disorders, including depression, are of great social importance and lead to serious everyday life infringement disability. disorders one the main causes suicide causes. Anxiety represent a variety psychic that often depression syndromes together seen in patients. Vitamin B12 (cobalamin) is only vitamin containing cobalt. Our aim was investigate, evaluate compare increased anxiety serum level patients with deficiency anemia healthy controls. We investigated 74 subjects – 38...
Summary Viruses transmitted by Aedes mosquitoes constitute an increasingly important global health burden. Defining common determinants of host susceptibility to this large group heterogenous pathogens are key for informing the rational design new pan-viral medicines. Infection vertebrate with these viruses is enhanced presence mosquito saliva, a complex mixture salivary gland-derived factors and microbiota. We show that enhancement infection saliva was dependent on vascular function...
Purpose: Some interleukins (ILs) play an important role in Graves’ orbitopathy (GO) pathogenesis. We aimed to compare serum IL-6, IL-8 and IL-10 GO patients, patients with disease (GD) without healthy controls (HC); follow IL changes during glucocorticoid (GC) treatment for GO; examine associations between ILs Clinical Activity Score (CAS).Materials Methods: Thirty-one active moderate-to-severe (GO(+) group), 30 GD (GO(-) group) HC were enrolled. At baseline, measured all groups, CAS was...