A5054075314- Innovations in Medical Education
- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Chemical synthesis and alkaloids
- Phenothiazines and Benzothiazines Synthesis and Activities
- Natural product bioactivities and synthesis
- Analytical Methods in Pharmaceuticals
- Traditional and Medicinal Uses of Annonaceae
- Asymmetric Synthesis and Catalysis
- Synthesis and pharmacology of benzodiazepine derivatives
- Pharmaceutical studies and practices
- Bioactive Compounds and Antitumor Agents
- Problem and Project Based Learning
- Phytochemistry and Biological Activities
- Nanocomposite Films for Food Packaging
- Chemical Synthesis and Analysis
- Pharmaceutical Practices and Patient Outcomes
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Analytical Chemistry and Chromatography
- Innovative Teaching Methods
- Radiology practices and education
- Advancements in Transdermal Drug Delivery
King Saud bin Abdulaziz University for Health Sciences
2012-2020
National Guard Health Affairs
2016-2020
King Abdulaziz Medical City
2019
Jordan University of Science and Technology
2007-2017
King Abdullah International Medical Research Center
2017
Virginia Tech
2005
Purdue University West Lafayette
1999-2003
Purdue Pharma (Canada)
2001
Introduction: The COVID-19 pandemic imposed dramatic changes on educational practices worldwide. Many universities and schools have moved into the delivery of their courses programs utilizing fully electronic online modes. This study aims to evaluate pharmacy student distance learning experience during pandemic. Methods: A cross-sectional survey was utilized where a 3-domain questionnaire focused preparedness, attitude barriers distributed students at time conclusion semester. Each domain...
Numerous studies have shown that students of health professions report higher perceived stress and lower quality life (QOL) levels than those in other disciplines. The purpose this cross-sectional survey study is to assess variations students' QOL by demographic college-related factors. World Health Organization (WHOQOL) – BREF Perceived Stress Scale (PSS-14) were used among at King Saud Bin Abdul-Aziz University for Sciences (KSAU-HS), Riyadh, during December 2015–June 2016. WHOQOL-BREF...
As part of our continuing investigation Jordanian Colchicum species, the biologically active components brachyphyllum were pursued. Using bioactivity-directed fractionation, nine colchicinoids isolated and characterized. One these has a novel ring system, to which we have ascribed trivial name (+)-demecolcinone (9), it represents first naturally occurring dextrorotatory colchicinoid. Another compound was new colchicinoid analogue, (−)-2,3-didemethyldemecolcine (8), while remaining seven...
N ‐Myristoyl transferase is an essential enzyme for fungal growth and survival. The continuous interest in the development of new antifungal agents prompted recent developing potent inhibitors ‐myristoyl transferase. In this context, we combined pharmacophore QSAR modeling to explore structural requirements employing 55 known ligands. Four binding models emerged optimal equations ( = 0.81–0.83, F ‐statistic 47.89–58.83, 0.77–0.80, against 11 external test 0.61–0.71). successful...
Farnesyltransferase enzyme (FTase) is considered an essential in the Ras signaling pathway associated with cancer. Thus, designing inhibitors for this might lead to discovery of compounds effective anticancer activity. In attempt obtain FTase inhibitors, pharmacophore hypotheses were generated using structure-based and ligand-based approaches built Discovery Studio v3.1. Knowing presence zinc feature inhibitor’s binding active site enzyme; further customization was applied include...
The shortage of clinical pharmacists in Saudi Arabia has limited the full implementation pharmaceutical care most its hospitals. National Guard Health Affairs This work discussed Department Pharmaceutical Care, and King Saud Bin Abdulaziz University for Sciences College Pharmacy four initiatives that were planned 2009-2010 to develop recruit pharmacists, practitioners, or faculty.The combined aimed at (1) instituting a 4-year skills development career ladder, (2) expanding postgraduate...
Twenty six α-substituted N4-acetamide derivatives of ciprofloxacin (CIPRO) and norfloxacin (NOR) were synthesized assayed for antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus Bacillus subtilis. The primarily more active Gram-positive bacteria. CIPRO derivatives, CD-7 (Ar = 3-chlorophenyl), CD-9 2-pyrimidyl) CD-10 (α-phenyl, Ar 2-pyrimidyl), exhibited lower MIC values, 0.4–0.9 μM, than CIPRO, while only compound better activity, 0.1 subtilis...
Despite the worldwide recognition of importance quality life (QOL) assessment, research data on QOL for renal and liver transplant recipients are limited. The main objective this study was to explore compare in patients.This cross-sectional conducted at King Abdulaziz Medical City, Saudi Arabia.Saudis 16 years age or more who received transplantation least three months before participated. evaluated using World Health Organization instrument (WHOQOL-BREF).Renal patients were highly...
Objective. To establish an academic curricular collaboration between the newly established college of pharmacy at King Saud Bin Abdulaziz Saudi University for Health Sciences (KSAU-HS) and a US accredited by Accreditation Council Pharmacy Education, assess measures success. Methods. Criteria selecting were established. A systematic approach was followed in negotiating legal, logistical, financial issues with selected collaborating institution. Course materials transferred implemented minimal...
Ketorolac, an NSAID, has low intrinsic permeation capacity through the skin. In this work, seven piperazinylalkyl ester prodrugs of ketorolac were synthesized to enhance its skin permeation. The chemical hydrolysis and stability in human serum at 37°C investigated buffer solutions (pH 5.0 7.4) 80% 7.4), respectively. chemically more stable pH than 7.4 with prodrug 8 being most (t1/2 = 119.75 h 11.97 5 7.4, respectively). prodrugs' t1/2 ranged from 0.79 3.92 min. aqueous solubility was...
A complex of low molecular weight chitosan (LMWC) with oleic acid and diclofenac potassium (DP) was prepared dispersed in high concentrations polysorbate 20, 60 80 water to form a solution which releases its components slowly. The formed characterized using different analytical methods. size the resulted nanoparticles effect tweens on were followed dynamic light scattering (DLS). release DP from this delivery system monitored by altering type concentration polysorbates used. most suitable...
BACKGROUND:Evidence suggests that patients who are more satisfied with their treatment show better adherence the prescribed therapy. Although there is valuable data about medication among renal transplant recipients (RTRs), a limited literature satisfaction and its relation to adherence. The aim of present study was investigate factors can predict explore relationship between in recipients. MATERIAL AND METHODS:Adult RTRs were included using convenient sampling. participants asked complete...
A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(−)-cornigerine (5), along with four known compounds, but to the species: (−)-colchicine (1), (−)-demecolcine (2), (−)-N-methyl-(−)-demecolcine (3) 3-demethyl-N-methyl-(−)-demecolcine (4). All compounds showed potent cytotoxicity against a human cancer cell panel.
Nicotinic acid is therapeutically the optimum antihyperlipidemic agent, yet its intolerable cutaneous flushing hinders wide clinical implication. The codrug of nicotinic and ibuprofen (IBP) was synthesized in aim overcoming troublesome side effect by blockade prostaglandin synthesis through released IBP, thus enhance patient's compliance. physico-chemical properties namely solubility, partition coefficient, pKa were determined. Its solubility aqueous organic solvents highest 0.1 M HCl...