A5002025964- Diabetes Management and Research
- Hemophilia Treatment and Research
- Botulinum Toxin and Related Neurological Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Glycosylation and Glycoproteins Research
- Protein purification and stability
- Advancements in Transdermal Drug Delivery
- Infant Nutrition and Health
Novo Nordisk (Denmark)
2010-2019
University of Copenhagen
2010-2011
Technical University of Denmark
2005
Fast-acting insulin aspart (faster aspart) is a novel formulation of containing two additional excipients: niacinamide, to increase early absorption, and L-arginine, optimize stability. The aim this study was evaluate the impact niacinamide on absorption investigate mechanism action underlying accelerated absorption.The assessed in pharmacokinetic analyses pigs humans, small angle X-ray scattering experiments, trans-endothelial transport assays, vascular tension measurements, subcutaneous...
Gangliosides are complex glycosphingolipids, which exert immune-modulating effects on various cell types. Ganglioside GD(3) and GM(3) the predominant gangliosides of human breast milk but during early phase lactation, content decreases while increases. The biological value in has yet to be elucidated when is ingested, dietary might conceptually affect immune cells, such as dendritic cells (DCs). In this study, we address vitro effect DC effector functionalities. Treatment bone marrow-derived...
Recombinant activated factor VII (rFVIIa; NovoSeven®) is a heterogeneously glycosylated serine protease used for treatment of haemophiliacs with inhibitors. The drug substance contains subpopulation consisting ~20% rFVIIa molecules which are unsialylated and consists carbohydrate moieties terminally exposed galactose N-acetyl-D-galactosamine (GalNAc). Recently, data from an in situ perfused liver model showed that rFVIIa, appearing to be was cleared by the liver, thus suggesting...
Recombinant activated factor VIIa (rFVIIa) is used for treatment of haemophilia patients with inhibitors. Tissue distribution studies in rats have shown that injected (125)I-rFVIIa accumulates organs such as the liver and kidneys. In this study, we explored which mechanism could be involved renal clearance rFVIIa.Immunohistochemistry was examination detail after injection rFVIIa to mice rats. Surface plasmon resonance evaluated specific binding megalin cubilin. The biological function...
Abstract Background In humans, subcutaneous administration of insulin in the abdominal region or arm is associated with a faster absorption compared to thigh buttocks. We hypothesised that this partly caused by differences injection depot structure and kinetics variability exposure differs between sites. Material methods Regional effects on pharmacokinetics were evaluated series studies Sprague Dawley rats dosed subcutaneously aspart neck flank. Injection depots visualised using µCT after...
Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations depot structure and kinetics the s.c. injection contribute delay.Rats fed a high-fat diet (HFD) low-fat (LFD) were included series pharmacokinetic imaging studies. Injection depots visualized micro X-ray computed tomography administration aspart mixed contrast agent iomeprol, exposure measured by means luminescent oxygen channelling...