A5100358828- Advanced biosensing and bioanalysis techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- DNA and Nucleic Acid Chemistry
- Lung Cancer Treatments and Mutations
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- RNA Research and Splicing
- Computational Drug Discovery Methods
- Protein Tyrosine Phosphatases
- RNA and protein synthesis mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Biosensors and Analytical Detection
- Advanced Proteomics Techniques and Applications
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Electrospun Nanofibers in Biomedical Applications
- Antimicrobial Peptides and Activities
- Molecular Sensors and Ion Detection
First Affiliated Hospital of Jinan University
2024
Chinese University of Hong Kong
2016
State Key Laboratory of Chemobiosensing and Chemometrics
2011
Qingdao University of Science and Technology
2011
Hunan University
2011
Lawrence Berkeley National Laboratory
2001
All systems GO! An intracellular protease sensor is based on the covalent conjugate of graphene oxide and peptide substrates with fluorophore labels. The can be delivered into live cells provides specific, high-contrast imaging caspase-3 activation (see picture; orange=cell penetration peptide, blue/black=caspase-3 probe). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
Monoclonal antibodies (mAbs) have become a major class of protein therapeutics that target spectrum diseases ranging from cancers to infectious diseases. Similar any molecule, mAbs are susceptible chemical modifications during the manufacturing process, long-term storage, and in vivo circulation can impair their potency. One such modification is oxidation methionine residues. Chemical occur complementarity-determining regions (CDRs) lead abrogation antigen binding reduce drug's potency...
Mesoporous bioactive glass (MBG) is a type of material with high biological activity and excellent biocompatibility. Because its specific surface area adjustable morphology, MBG usable for loading delivering molecules. In our previous report, particles were used as gene vectors showed good transfection rate. this paper, MBG, prepared through sacrificial liquid template method in sol–gel process, was covered polyglycerol (PG) the resulting MBG-PG further functionalized octaarginine (Arg8....
Dynamic tracking analysis of monoclonal antibodies (mAbs) biotransformation
Reactive oxygen species can modify the structure and function of proteins may also act as important signaling molecules in various cellular processes. Cysteine thiol groups are particularly susceptible to oxidation. Meanwhile, their reversible oxidation is critical roles for redox regulation signaling. Recently, several computational tools have been developed predicting redox-sensitive cysteines; however, those methods either only focus on catalytic cysteines oxidoreductases, or heavily...
Timely and accurate primary tumor diagnosis is critical, misdiagnoses delays may cause undue health economic burden. To predict types based on genomics data from a de-identified US nationwide clinico-genomic database (CGDB), the XGBoost-based Clinico-Genomic Machine Learning Model (XC-GeM) was developed to 13 12,060 patients in CGDB, derived routine clinical comprehensive genomic profiling (CGP) testing chart-confirmed electronic records (EHRs). The SHapley Additive exPlanations method used...
<p>This file includes Supplemental materials and methods, references, figure legends</p>