A5079156617- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Developmental Biology and Gene Regulation
- Acute Lymphoblastic Leukemia research
- HIV Research and Treatment
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- RNA modifications and cancer
- Renal and related cancers
Universidad Autónoma de Madrid
2007-2024
Centro de Biología Molecular Severo Ochoa
2007-2024
Consejo Superior de Investigaciones Científicas
2007-2022
NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL), but crucial downstream signals and target genes contributing to T-ALL pathogenesis cannot be retrospectively analyzed patients thus remain ill defined. This information clinically relevant, as initiating lesions that lead transformation leukemia-initiating (LIC) activity are promising therapeutic targets against the major hurdle of relapse. Here, we describe generation vivo human recapitulates patients,...
A key unsolved question regarding the developmental origin of conventional and plasmacytoid dendritic cells (cDCs pDCs, respectively) resident in steady-state thymus is whether early thymic progenitors (ETPs) could escape T cell fate constraints imposed normally by a Notch-inductive microenvironment undergo DC development. By modeling generation bulk clonal cultures, we show here that Jagged1 (JAG1)-mediated Notch signaling allows human ETPs to undertake myeloid transcriptional program,...
Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended role to thymic epithelial cells (TECs), showing that regulates TEC progenitor maintenance emergence medullary TECs (mTECs) in fetal thymopoiesis. Based on immunohistochemistry spatiotemporal regulation activation postnatal thymus, we show vivo not confined TECs. Rather, signaling, likely mediated through Notch1 receptor, induced cortical TECs,...
ABSTRACT Natural Killer (NK) cells are promising tools for the development of immunotherapies targeting persistently infected CD4+ T to potentially achieve remission in people with HIV-1 (PWH). However, chronicity infection limits functional properties NK cells, and additional approaches needed potentiate their cytotoxic activity against HIV-1-infected cells. In present study, we analyzed reinvigoration from PWH after priming autologous dendritic (DC) stimulated nanoparticles containing Poly...
SUMMARY Targeted immunotherapy for T-cell acute lymphoblastic leukemia (T-ALL), an aggressive tumor of developing progenitors, is urgent unmet need, especially relapsed/refractory (r/r) disease. Selective T-ALL targeting challenging due to the shared antigen expression between leukemic and normal T cells. Here we identify pre-TCR, a surface receptor essential development, as biomarker leukemia-initiating cells (LICs) in human T-ALL. Loss-of-function genetic approaches demonstrate that...
ABSTRACT T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by high rates of induction failure and relapse, effective targeted immunotherapies are lacking. Despite promising clinical progress with genome-edited CD7-directed CAR-T cells, which present significant logistical regulatory issues, therapy in T-ALL remains challenging due to the shared antigen expression between malignant healthy cells. This can result fratricide, aplasia, potential for blast...