A5063130437- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Heat shock proteins research
Sun Yat-sen University
2022-2025
Sun Yat-sen Memorial Hospital
2022-2025
Immunogenic cell death (ICD) is a distinct subtype of regulatory death, and represents potential mechanism to remodel the tumor microenvironment. Lenvatinib established as first-line therapy for advanced hepatocellular carcinoma (HCC), but drug resistance limits its efficiency. Our previous research showed that lenvatinib can inhibit GPX2 expression induce reactive oxygen species (ROS)-related apoptosis in HCC. The present study intends explore whether ICD clarify underlying mechanisms Flow...
Abstract Purpose: Tyrosine kinase inhibitors (TKIs) combined with immune checkpoint blockades (ICBs) produce enhanced anti-tumor activity in the treatment of advanced hepatocellular carcinoma (HCC). Sitravatinib is a novel multi-target TKI that targets TYRO3, AXL, MERTK (TAM) receptors, c-MET, etc. This study aimed to investigate efficacy and immunomodulatory sitravatinib HCC. Experimental Design: Human HCC cell lines xenograft models were used explore sitravatinib. Subcutaneous orthotopic...
Solute carrier family 39 member 1 (SLC39A1) has been identified as a zinc ion transport protein that possesses oncogenic properties in various types of cancers. However, its potential function hepatocellular carcinoma (HCC) remains unknown. This study aimed to investigate the expression profile and mechanisms SLC39A1 HCC.SLC39A1 was analyzed using multiple databases. The clinical significance associated biological pathways were investigated bioinformatics analysis. Potential correlations...