Background Recent reports suggest that immigrants from Middle Eastern countries are a high-risk group for type 2 diabetes (T2D) compared with Swedes, and the pathogenesis of T2D may be ethnicity-specific. Deregulation microRNA (miRNA) expression has been demonstrated to associated but ethnic differences in miRNA have not investigated. The aim this study was explore specific (Swedish Iraqi) panel 14 previously identified miRNAs patients without (including those prediabetes) T2D. Methods A...

Individual-based cognitive-behavioural therapy (CBT) is in short supply and expensive.The aim of this randomised controlled trial (RCT) was to compare mindfulness-based group with treatment as usual (primarily individual-based CBT) primary care patients depressive, anxiety or stress adjustment disorders.This 8-week RCT (ClinicalTrials.gov ID: NCT01476371) conducted during spring 2012 at 16 general practices Southern Sweden. Eligible (aged 20-64 years) scored ≥10 on the Patient Health...

Depressive/anxiety disorders are the most common types of mental illnesses in world. The present study was first to explore association between plasma microRNAs (miRNAs) and depression/anxiety primary care patients.In total, 169 patients (aged 20-64 years) from 16 health centers were enrolled study. healthy controls consisted 52 individuals. We performed miRNA screening samples 11 using a Serum/Plasma Focus microRNA Panel comprising 179 primer sets. Six miRNAs differentially expressed then...

Summary For excluding deep-vein thrombosis (DVT), a negative D-dimer and low clinical probability are used to rule out DVT. Circulating microRNAs (miRNAs) stably present in the plasma, serum other body fluids. Their diagnostic function has been investigated many diseases but not The aims of study were assess ability plasma miRNAs DVT examine their correlation with known markers hypercoagulability, such as APC-PCI complex. Plasma samples obtained from 238 patients (aged 16–95 years) suspected...

Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated VTE and markers hypercoagulability, this study is the examine whether miRNAs A nested case-control design was used where plasma samples were obtained from 78 patients Malmö Thrombophilia Study (MATS). total 39 recurrent (cases) matched without (controls) defined by age sex (MATS population). Plasma levels 179 different...

Abstract Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. DNA copy number (mtDNA-CN) indirect measure mitochondrial associated with type 2 diabetes mellitus (T2DM); however, whether mtDNA-CN can predict risk developing T2DM not well-known. We quantified absolute both prevalent incident by well-optimized droplet digital PCR (ddPCR) method population-based follow-up study middle aged (50–59 years) Swedish women (n = 2387). The...

Introduction: Xinjiang Brown cattle are a famous dual-purpose (dairy-beef) cultivated breed in China that occupy pivotal position within the breeding industry Xinjiang, China. However, little information is available on genetic background of this breed. To fill research gap, we conducted whole-genome screen using specific-locus amplified fragment sequencing to examine structure and diversity 130 cattle-grazing type (XBG, traditional type) cattle. Methods: A subsequent joint analysis...

Abstract Background The exosomal lncRNA-miRNA-mRNA networks in first episode schizophrenia (FOS) have not reported yet. This study examined the lncRNA, miRNA and mRNA expression level exosome derived from patients, explored potential of exosomes as biomarkers for schizophrenia. Methods We recruited 10 FOS patients healthy controls (HCs) respectively, plasma by high throughput sequencing, constructed network, performed correlation analysis, GO KEGG pathway PPI network construction ROC...

Changes in mitochondrial DNA copy number (mtDNA-CN) and telomere length have, separately, been proposed as risk factors for various cancer types. However, those results are conflicting. Here, mtDNA-CN relative were measured 3225 middle-aged women included a large population-based prospective cohort. The baseline patients with prevalent breast was significantly higher (12.39 copies/µL) than cancer-free individuals. During an average of 15.2 years follow-up, 520 diagnosed cancer. Lower...

Abstract Background Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, subsequent risk incident IBD still unexplored. This study aimed to investigate ZRP both and IBD. Method The included a total 130 women (51–61 years) from Women’s Health in Lund Area (WHILA) study, which 18 (diagnosed before baseline) 47 diagnosed during 17 years (median) follow-up age- sampling time-matched...

The aim of this study is to investigate how genetic variations in genes related oxidative stress, intake antioxidant vitamins, and any potential interactions between these factors affect the incidence intact abdominal aortic aneurysm (AAA) its rupture (rAAA), accounting for sex differences where possible. present retrospective cohort (n = 25 252) uses baseline single-nucleotide polymorphisms (SNPs) total vitamin data from large population-based, Malmö Diet Cancer Study. Cumulative AAA was...

Summary Plasminogen-activator inhibitor (PAI)-1 is an important of the plasminogen/plasmin system. PAI-1 levels are influenced by 4G/5G polymorphism in promoter. We investigated relationship between and VTE recurrence, its possible modification factor V Leiden (FVL) prothrombin (PTM) mutations. Patients (n=1,069) from Malmö Thrombophilia Study were followed discontinuation anticoagulant treatment until diagnosis recurrence or end study (maximum follow-up 9.8 years). One hundred twenty-seven...

Abdominal aortic aneurysm (AAA) is a life-threatening condition with mortality rate of over 80%. Persistent smoking, which risk factor for AAA, has lasting effects on DNA methylation. Moreover, plasma-amino acid, homocysteine, previously implicated in vascular diseases, including aneurysms, well-established biological association In the present study, we aimed to determine global methylation, homocysteine levels and their AAA its growth. Enzyme-linked immunosorbent assay (ELISA) was used...

Beef flavor plays a crucial role in consumer preference, yet research on this trait has been limited by past technological constraints. Intramuscular fat (IMF) is key determinant of beef quality, influencing taste, marbling, and overall flavor. Xinjiang brown cattle (XBC), an indigenous breed from northern Xinjiang, China, presents significant variation meat with IMF content ranging 0.2 % to 4.3 within the population. This suggests strong potential for breeding improvement. In study, we...

Abstract Background Major depressive disorder (MDD) is one of the most common psychiatric disorders and a great disease burden. However, its underlying pathophysiology aetiology remain poorly understood. Available evidence suggests that circulating microRNAs (miRNAs) are associated with MDD, but it still unknown whether miRNAs can predict subsequent incident MDD. Methods In this nested case-control study, total 104 individuals, who were free MDD at baseline, from Women’s Health in Lund Area...

Heart failure (HF) is a leading cause of death in both men and women. However, risk factors seem to differ for women significant gaps sex-specific knowledge exist. Mitochondria are critical cardiomyocytes this study, we investigated the role baseline mitochondrial DNA copy number (mtDNA-CN) HF incidence middle-aged its possible association between myocardial infarction (MI) HF. Finally, also whether mtDNA-CN was associated with overall mortality. Baseline levels were quantified by droplet...

To investigate the associations between cytokines and insulin sensitivity in Swedish residents born Iraq Sweden.Cross-sectional study.Iraqi origin of Rosengård area Malmö, aged 45-65 years, were randomly selected from census register.194 (Iraqi, n=107; Swedish, n=87) participants agreed to participate study. Nineteen dropped out n=11; n=8). Participants who had already been diagnosed with type 2 diabetes mellitus (T2DM), those could not an oral glucose tolerance test a cold/fever at time...

Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA (mtDNA) copies range from 100s 10,000s per cell, thus providing a potentially alternative identify potential missing circulation at an stage.To characterize mutation landscapes breast cancer, whole mtDNA sequencing bioinformatics analyses were performed on 86 biopsies 50 available...

Abstract Objectives Most signatures are constructed on the basis of RNA or protein expression levels. The value vascular invasion-related based lncRNA pairs, regardless their specific level in hepatocellular carcinoma (HCC), is not yet clear. Methods Vascular differentially expressed (DElncRNA) pairs were identified with a two-lncRNA combination strategy by using novel modeling algorithm. Based optimal cutoff ROC curve, patients HCC classified into high- and low-risk subgroups. We used KM...