A5062558482- Cancer therapeutics and mechanisms
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Drug Transport and Resistance Mechanisms
- CAR-T cell therapy research
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- COVID-19 epidemiological studies
- Genomics and Rare Diseases
- RNA Interference and Gene Delivery
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Natural Compounds in Disease Treatment
- Chromosomal and Genetic Variations
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 detection and testing
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
University of Foggia
2024
Istituto Ortopedico Rizzoli
2018-2023
Ceinge Biotecnologie Avanzate (Italy)
2017
University of Naples Federico II
2017
The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by drug. A1 (ABCA1) isopentenyl pyrophosphate (IPP), a strong activator of anti-tumor Vγ9Vδ2 T-cells. Recruiting this population may represent an alternative strategy to rescue doxorubicin efficacy ABCB1-expressing osteosarcoma. In work, we analyzed how ABCA1 ABCB1 are regulated if...
Treatment of high-grade osteosarcoma, the most common malignant tumor bone, is largely based on administration cisplatin and other DNA damaging drugs. Altered repair mechanisms may thus significantly impact either response or resistance to chemotherapy. In this study, by using a panel human osteosarcoma cell lines, sensitive resistant cisplatin, we assessed value as candidate therapeutic targets repair-related factors belonging nucleotide excision (NER) base (BER) pathways, well group 18...
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability (ID). Together with fragile X-associated tremor and ataxia (FXTAS) premature ovarian failure (POF)/primary insufficiency (POI), FXS depends on dysfunctional expression FMR1 gene Xq27.3. In cases, caused by a > 200 CGG repeats in 5′-untranslated region (UTR) promoter hypermethylation that results silencing. Males females unmethylated premutated alleles (repeats between 55 200) are at risk for FXTAS POF/POI....
Cisplatin (CDDP) is a drug for high-grade osteosarcoma (HGOS) treatment. Several germline pharmacogenetic studies have revealed associations between single nucleotide polymorphisms (SNPs) and CDDP-based therapy response or CDDP-related toxicity in patients with HGOS. Whether these variants could play biological role HGOS cells has not been studied so far. The aim of this study was to explore 28 SNPs 14 genes 6 CDDP-resistant 12 drug-sensitive human cell lines. An innovative multimodal...
Wiedemann-Steiner syndrome (WSS), a rare autosomal-dominant disorder caused by haploinsufficiency of the
Introduction: Methotrexate (MTX) is one of the most important drugs included in first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported be associated with drug response or MTX-related toxicity pharmacogenetic studies, their role development MTX resistance HGOS still unclear. Methods: Therefore, this study, 22 single nucleotide (SNPs) 4 genes folate metabolism, 7 transporter genes, and 2 SNPs tumor protein p53 ( TP53 ) gene were...