A5028628967- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- X-ray Diffraction in Crystallography
- Ferroptosis and cancer prognosis
- Crystallization and Solubility Studies
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Oral and Maxillofacial Pathology
- Immunotherapy and Immune Responses
- Oral Health Pathology and Treatment
- Sarcoma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Cholesterol and Lipid Metabolism
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular Junctions and Nanostructures
- RNA Research and Splicing
- Esophageal Cancer Research and Treatment
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
University of Turin
2020-2024
Doxorubicin (Dox) is one of the most important first-line drugs used in osteosarcoma therapy. Multiple and not fully clarified mechanisms, however, determine resistance to Dox. With aim identifying new markers associated with Dox-resistance, we found a global up-regulation small nucleolar RNAs (snoRNAs) human Dox-resistant cells. We investigated if how snoRNAs are linked resistance. After RT-PCR validation up-regulated cells different degrees Dox, overexpressed them Dox-sensitive then...
The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by drug. A1 (ABCA1) isopentenyl pyrophosphate (IPP), a strong activator of anti-tumor Vγ9Vδ2 T-cells. Recruiting this population may represent an alternative strategy to rescue doxorubicin efficacy ABCB1-expressing osteosarcoma. In work, we analyzed how ABCA1 ABCB1 are regulated if...
Mixed-valence (MV) binuclear ferrocenyl compounds have long been studied as models for testing theories of electron transfer and in attempts to design molecular-scale electronic devices (e.g., molecular wires). In contrary that, far less attention has paid MV ferrocenes anticancer agents. Herein, we discuss the synthesis six 1,2,3-triazole combined (spectro)electrochemical, paramagnetic resonance (EPR), computational, activity studies. Our synthetic approach was based on copper-catalyzed...
Solid tumors subjected to intermittent hypoxia are characterized by resistance chemotherapy and immune-killing effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular circuitries determining this double not known.We analyzed a panel of 28 human non-small cell lung cancer (NSCLC) lines, using an in vitro system simulating continuous hypoxia. Chemosensitivity cisplatin docetaxel was evaluated chemiluminescence, ex vivo T-lymphocyte expansion flow cytometry....
Doxorubicin is a strong inducer of immunogenic cell death (ICD), but it ineffective in P-glycoprotein (Pgp)-expressing cells. Indeed, Pgp effluxes doxorubicin and impairs the immunesensitizing functions calreticulin (CRT), an “eat-me” signal mediating ICD. It unknown if classical inhibitors, designed to reverse chemoresistance, may restore We addressed this question by using Pgp-expressing cancer cells, treated with Tariquidar, clinically approved inhibitor, R-3 compound,...
Glioblastoma multiforme (GBM) is an aggressive tumor, difficult to treat pharmacologically because of the blood-brain barrier (BBB), which rich in ATP-binding cassette (ABC) transporters and tight junction (TJ) proteins. The BBB disrupted within GBM bulk, but it competent brain-adjacent-to-tumor areas, where eventual foci can trigger tumor relapse. How cells influence permeability poorly investigated.
In non-small cell lung cancer (NSCLC) the efficacy of chemo-immunotherapy is affected by high expression drug efflux transporters as ABCC1 and low ABCA1, mediating isopentenyl pyrophosphate (IPP)-dependent anti-tumor activation Vγ9Vδ2 T-lymphocytes. endothelial cells ABCA1 a predicted target transcription factor EB (TFEB), but no data exists on correlation between TFEB ABC involved in chemo-immuno-resistance NSCLC.
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Abstract Background. Solid tumors subjected to intermittent hypoxia are characterized by resistance chemotherapy and immune-killing effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular circuitries determining this double not known. Methods. We analyzed a panel of 28 human non-small cell lung cancer (NSCLC) lines, using an in vitro system simulating continuous hypoxia. Chemosensitivity cisplatin docetaxel was evaluated chemiluminescence, ex vivo...
Abstract Background : Solid tumors subjected to intermittent hypoxia are characterized by resistance chemotherapy and immune-killing effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular circuitries determining this double not known. Methods: We analyzed a panel of 28 human non-small cell lung cancer (NSCLC) lines, using an in vitro system simulating continuous to. Chemosensitivity cisplatin docetaxel was evaluated chemiluminescence, ex vivo T-lymphocyte...
Abstract Background. Solid tumors subjected to intermittent hypoxia are characterized by resistance chemotherapy and immune-killing effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular circuitries determining this double not known. Methods. We analyzed a panel of 28 human non-small cell lung cancer (NSCLC) lines, using an in vitro system simulating continuous hypoxia. Chemosensitivity cisplatin docetaxel was evaluated chemiluminescence, ex vivo...