A5089134942- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Enzyme Catalysis and Immobilization
- Phytochemicals and Antioxidant Activities
- Phytochemical compounds biological activities
- Medicinal Plant Pharmacodynamics Research
- Food Quality and Safety Studies
- Microbial Metabolites in Food Biotechnology
- Plant biochemistry and biosynthesis
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- Seaweed-derived Bioactive Compounds
- Electrochemical sensors and biosensors
- Protein Tyrosine Phosphatases
- Enzyme Production and Characterization
- Fungal Biology and Applications
- Analytical Chemistry and Chromatography
- Phytochemistry and Bioactivity Studies
- Neuropeptides and Animal Physiology
- Phytochemistry and biological activity of medicinal plants
- Receptor Mechanisms and Signaling
- Algal biology and biofuel production
- Microbial Metabolic Engineering and Bioproduction
- Mass Spectrometry Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
Dalian Ocean University
2016-2025
Dalian Polytechnic University
2022-2023
Dalian University
2017-2020
National Heart Lung and Blood Institute
2011-2018
National Institute of Biomedical Imaging and Bioengineering
2010-2017
National Institutes of Health
2010-2017
Xinjiang Technical Institute of Physics & Chemistry
2009-2014
Chinese Academy of Sciences
2007-2014
Fudan University
2013
University of Chinese Academy of Sciences
2009-2010
Gracilaria lemaneiformis, an edible alga, with various bioactivities is a traditional dish and favorite food. In the present study, its n-hexane extract showed strong protein tyrosine phosphatase 1B inhibitory activity after screening. To understand composition, nineteen compounds were identified from this by GC-MS. The of was further screened means molecular docking individually. As result, 2,2'-methylenebis-6-(1,1-dimethylethyl)-4-methyl-phenol lowest binding energy -6.70 kcal mol-1...
Radiolabeled bombesin (BBN) analogs have long been used for developing gastrin-releasing peptide receptor (GRPR) targeted imaging probes, and tracers with excellent in vivo performance including high tumor uptake, contrast, favorable pharmacokinetics are highly desired. In this study, we compared the 68Ga-labeled GRPR agonist (Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, BBN7-14) antagonist (d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2, RM26) positron emission tomography (PET) of prostate cancer. The...
Ellagic acid is one of the most representative natural antioxidants, and rich in pomegranate peel. In this study, a consecutive countercurrent chromatographic (CCC) separation method was established to improve preparative efficiency ellagic from By optimizing solvent system, sample size flow rate, 280 mg obtained 5 g crude peel by CCC after six injections. Moreover, values EC50 for scavenging ABTS·+ DPPH· were 4.59 ± 0.07 10.54 μg/ml, respectively, indicating strong antioxidant activity....
Abstract Introduction – Artemisia rupestris L. is a well‐known traditional Chinese medicinal plant in Xinjiang. Rupestonic acid the main active ingredient of A. L., and has been chosen as ‘marker compound’ for chemical evaluation or quality control its products. Although HSCCC separation method was developed before, performed with two steps using same solvent system, which were time‐consuming waste solvents. Objective To develop simple purification rupestonic single run. Methodology The...
Robinia pseudoacacia flower is a natural product with many biological activities, including antioxidation. To further develop its antioxidation, the extract was fermented by Aspergillus niger FFCC 3112 in medium carbon to nitrogen ratio of 1.4:1 and initial pH 4.2 for 3.5 days form best antioxidant activity fermentation strain screening, single factor optimization, response surface methodology. Further analysis, isolation determination showed that main chemical component,...
Robinia pseudoacacia flowers have attracted much attention because of numerous bioactivities. In this study, its extract showed the potential scavenging ability for 2,2′‐azinobis‐(3‐ethylbenzthiazoline‐6‐sulphonate) and 1,1‐diphenyl‐2‐picrylhydrazyl free radicals. Under guidance antioxidant activity, was enriched by liquid‐liquid extraction. The partition coefficients two main components in extracts differed greatly, so elution‐extrusion counter‐current chromatography with solvent system n...
Coprinus comatus is an edible and medicinal fungus. In this study, the antioxidant activity of fermentation product C. was investigated through optimization process. The results indicated that had obvious scavenging ability for 2,2'-Azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) free radical. EC50 n-butanol extract from on ABTS·+ 0.65 ± 0.02 mg/mL. On basis, liquid conditions were optimized single factor response surface experiments according to improve capacity product. showed...