A5100694163- Optimal Power Flow Distribution
- Smart Grid Energy Management
- Electric Power System Optimization
- Microgrid Control and Optimization
- Power System Optimization and Stability
- Power Systems and Technologies
- Islanding Detection in Power Systems
- Power System Reliability and Maintenance
- Reconstructive Surgery and Microvascular Techniques
- Aortic Disease and Treatment Approaches
- Dermatology and Skin Diseases
- Aortic aneurysm repair treatments
- Allergic Rhinitis and Sensitization
- Electric Vehicles and Infrastructure
- Cutaneous Melanoma Detection and Management
- Forensic Anthropology and Bioarchaeology Studies
- Reconstructive Facial Surgery Techniques
- Multi-Agent Systems and Negotiation
- Auction Theory and Applications
- Trauma Management and Diagnosis
- Wound Healing and Treatments
- Face recognition and analysis
- Asthma and respiratory diseases
- Advanced Image Processing Techniques
- Image Processing Techniques and Applications
University of Tsukuba
2014-2025
Mizuho (Japan)
2014-2024
Daiyukai General Hospital
2007-2024
Meiji Gakuin University
2023
Hiroshima Institute of Technology
2011-2021
Japan Tobacco (Japan)
2017-2021
Nara Medical University
2000-2020
Hamamatsu University School of Medicine
2010-2018
Seirei Hamamatsu General Hospital
2018
Hamamatsu Medical Center
2018
BackgroundPrevious studies showed the potential effectiveness of delgocitinib ointment, a novel topical Janus kinase inhibitor, in atopic dermatitis (AD).ObjectiveThis study aimed to evaluate efficacy and safety 0.5% ointment.MethodsIn part 1, 4-week double-blind period, Japanese patients aged 16 years or older with moderate severe AD were randomly assigned 2:1 ratio ointment vehicle ointment. Eligible entered 2, 24-week extension receive ointment.ResultsAt end treatment least-squares mean...
JTE‐052 is a novel Janus kinase inhibitor presently under clinical development for the topical treatment of atopic dermatitis (AD). To evaluate efficacy and safety ointment in Japanese adult patients with AD. Patients moderate‐to‐severe AD were randomized (2: 2: 1: 1) to receive at 0·25%, 0·5%, 1% or 3%, vehicle tacrolimus 0·1% (reference) twice daily 4 weeks. The primary end point was percentage change modified Eczema Area Severity Index (mEASI) score from baseline (EOT). Secondary points...
Topical delgocitinib (JTE-052), a novel Janus kinase inhibitor, had been shown to be clinically effective in adults with atopic dermatitis (AD). However, the efficacy of topical pediatric patients AD remained unclear.We sought evaluate and safety ointment AD.In this phase 2 clinical study (JapicCTI-173553) Japanese aged through 15 years were randomized 1:1:1 ratio receive 0.25% or 0.5% vehicle twice daily for 4 weeks. The primary end point was percentage change from baseline modified Eczema...
Delgocitinib 0.5% ointment, a topical Janus kinase inhibitor, has been approved in Japan for adult patients with atopic dermatitis (AD).To evaluate the efficacy and safety of delgocitinib ointment pediatric AD.Part 1 this study was 4-week double-blind period which Japanese aged 2 through 15 years were randomized 1:1 ratio to 0.25% or vehicle ointment. Part 52-week extension period. Eligible entered part receive ointment.At initiation study, approximately half had moderate AD. At end...
Abstract Previous studies demonstrated that delgocitinib ointment, a novel topical Janus kinase inhibitor, rapidly improved clinical signs and symptoms of atopic dermatitis (AD) in Japanese adult patients. We sought to evaluate the long‐term safety efficacy 0.5% ointment 52‐week study (QBA4‐2). patients aged 16 years or older with AD received b.i.d. for up 52 weeks. Topical corticosteroids treatment worsening could be used at investigators’ discretion during period. Safety end‐points...
This article presents a method for detecting damaged buildings in the event of an earthquake using machine learning models and aerial photographs. We initially created training data photographs captured around town Mashiki immediately after main shock 2016 Kumamoto earthquake. All are classified into one four damage levels by visual interpretation. Subsequently, two discrimination developed: bag-of-visual-words model based on convolutional neural network. Results compared validated terms...
Abstract The purpose of the present two phase 1 studies was to assess safety, tolerability and pharmacokinetics for topical application a novel Janus kinase ( JAK ) inhibitor, JTE ‐052, in Japanese healthy adult male volunteers patients with atopic dermatitis AD ). Additionally, exploratory investigation performed on efficacy disease severity pruritus score patients. In QBX 1‐1 study, cutaneous safety ‐052 ointment by patch test photo assessed an intra‐individual comparative study using...
Sleep is generally viewed as a period of recovery, but how the supply cerebral blood flow (CBF) changes across sleep/wake states has remained unclear. Here, we directly observe red cells (RBCs) within capillaries, where actual substance exchange between and neurons/glia occurs, by two-photon microscopy. Across multiple cortical areas, average capillary CBF largely increased during rapid eye movement (REM) sleep, whereas it does not differ periods active wakefulness non-REM sleep. Capillary...
Purpose:To evaluate the feasibility and efficacy of a newly designed stent-graft placed across renal arteries for exclusion abdominal aortic aneurysms (AAAs) with short or tortuous proximal ...
Wound compression and fixation are important to reduce scarring. Numerous postoperative treatments have been developed scar formation; however, a simple effective device that improves the appearance histochemical properties of incisional scars is needed. Therefore, authors devised novel method, negative-pressure fixation, applies negative pressure inside polyurethane foam covered with film. In present study, was applied wounds resulting from insertion tissue expander in patients undergoing...
This paper proposes a multi-agent approach to decentralized distribution power system restoration. So far, numerous studies have been conducted on restoration problems. From the view point of structures, these researches can be divided into two categories: centralized systems and systems. In this study, we solved problem by using approach, which is categorized in distributed approach. The solutions compared with were mathematical programming simulation results, it seen proposed method could...
Age estimation from bones plays a major role in the identification of skeletal remains. We present novel age method developed through application machine learning (ML) to post-mortem computed tomography (PMCT) images bones. This study used PMCT vertebral body, ischial tuberosity, iliac crest, and femur, which were transformed into homologous models. Two-dimensional discrete wavelet transform (2D-DWT) was conducted extract high-frequency components. Dimensionality reductions prepared data...
To report a case of deteriorating consumptive coagulopathy with type III endoleak following endovascular aneurysm repair (EVAR) the abdominal aorta associated liver cirrhosis.A 72-year-old man cirrhosis developed EVAR. Spontaneous intramuscular hematoma due to induced by and dysfunction. Although additional EVAR was performed at 52 months after primary EVAR, patient died multiorgan failure multifocal muscles subserosa.EVAR for patients dysfunction should be considered great caution. We...
To assess the efficacy of combined therapy involving bland transarterial embolization using gelatin sponge particles (bland GS-TAE) followed by chemoembolization lipiodol mixed with anticancer agents and GS (Lip-TACE) to reduce adverse events increase therapeutic effect Lip-TACE in treatment huge (≥10 cm) hepatocellular carcinoma (HCC).Twenty-one consecutive patients HCCs cm diameter) were enrolled this study. First, GS-TAE was performed tumor volume, then control remaining at intervals...