A5045477726- Ocular Oncology and Treatments
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Corneal surgery and disorders
- Radiation Therapy and Dosimetry
- Retinal and Macular Surgery
- Advanced Optical Sensing Technologies
- Retinal Diseases and Treatments
- Retinopathy of Prematurity Studies
- Optical measurement and interference techniques
- Ocular Diseases and Behçet’s Syndrome
- Gaze Tracking and Assistive Technology
- Nonmelanoma Skin Cancer Studies
- Photodynamic Therapy Research Studies
- Intraocular Surgery and Lenses
- Ocular and Laser Science Research
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Radiation Detection and Scintillator Technologies
- Optical Systems and Laser Technology
- Optical Polarization and Ellipsometry
- Electron Spin Resonance Studies
Paul Scherrer Institute
2019-2024
Politecnico di Milano
2015-2019
Fondazione IRCCS Istituto Nazionale dei Tumori
2016
Purpose Only few centers worldwide treat intraocular tumors with proton therapy, all of them a dedicated beamline, except in one case the USA . The Italian National Center for Oncological Hadrontherapy (CNAO) is synchrotron‐based hadrontherapy facility equipped fixed beamlines and pencil beam scanning modality. Recently, general‐purpose horizontal beamline was adapted to also ocular diseases. In this work, conceptual design main dosimetric properties new eyeline are presented. Methods A 28...
In-room magnetic resonance imaging (MRI) allows the acquisition of fast 2D cine-MRI centered in tumor for advanced motion management radiotherapy. To achieve 3D information during treatment, patient-specific models can be considered most viable solution. However, conventional global are built using a single surrogate, independently from anatomical location. In this work, we present novel model based on regions interest (ROIs) established 4D computed tomography (4DCT) and cine-MRI, aiming at...
Purpose: External beam radiotherapy currently represents an important therapeutic strategy for the treatment of intraocular tumors. Accurate target localization and efficient compensation involuntary eye movements are crucial to avoid deviations in dose distribution with respect plan. This paper describes tracking system (ETS) based on noninvasive infrared video imaging. The was designed capturing tridimensional (3D) ocular motion provides on‐line estimation lesions position a priori...
MRI-treatment units enable 2D cine-MRI centred in the tumour for motion detection radiotherapy, but they lack 3D information due to spatio-temporal limits. To derive time-resolved information, different approaches have been proposed literature, a rigorous comparison among these strategies has not yet performed. The goal of this study is quantitatively investigate five published that volumetric MRI MRI-guided radiotherapy: Propagation, out-of-plane compensation, Fayad model, ROI-based model...
We present the commissioning and quality assurance of our clinical protocol for respiratory gating in pencil beam scanning proton therapy cancer patients with moving targets. In a novel approach, optical tracking has been integrated workflow used to monitor motion from multiple surrogates, applied on patients' chest. The system was tested under variety experimental conditions, specific therapy, evaluate reaction time reproducibility dose delivery control. proved be precise application...
Ocular proton therapy (OPT) for the treatment of uveal melanoma has a long and remarkably successful history. This is despite that, majority patients treated, definition eye anatomy based on simplified geometrical model embedded in planning system EyePlan. In this study, differences anatomical tumor structures from EyePlan, those 1.5T magnetic resonance imaging (MRI) are assessed.Thirty-three treated with OPT at our institution were subject to MRI. The target volumes manually delineated...
Purpose Over the last four decades, Ocular Proton Therapy has been successfully used to treat patients affected by intraocular lesions. For this, treatment geometry verification is routinely performed using radiographic images align a configuration of fiducial radiopaque markers implanted on sclera outer surface. This paper describes clinical application an alternative approach based optical eye tracking for three‐dimensional noninvasive and automatic localization. An experimental protocol...
Purpose Ocular proton therapy is an effective therapeutic option for patients affected with uveal melanomas. An optical eye‐tracking system (ETS) aiming at noninvasive motion monitoring was developed and tested in a clinical scenario. Materials methods The ETS estimates eye position orientation 25 frames per second using the three‐dimensional of pupil cornea curvature centers identified, treatment room, through stereoscopic imaging infrared illumination. Its capabilities automatic detection...
Motion of the tumour during a radiotherapy treatment can compromise clinical outcome for cancer patient. To address this challenge suitability and performance Intel RealSense™ D415 depth camera has been investigated as tool measuring respiratory motion body surface. The precision data characterised function measurement distance up to 1.2 meters from stationary moving latency system was also measured. average standard deviation in measurements ranged less than 0.2 mm shortest camera-surface...
Abstract Introduction: 
This study aims to assess the effective lateral margin requirements for target coverage in ocular proton therapy (OPT), considering unique challenges posed by eye motion and hypofractionation. It specifically addresses previously unaccounted-for uncertainty contribution of intra-fractional motion, conjunction with setup uncertainties, on dosimetric determination requirements. 


Method: 
The methodology integrates dose...
The introduction of non-invasive imaging techniques such as MRI for treatment planning and optical eye tracking in-room localization would obviate the requirement clips implantation many patients undergoing ocular proton therapy. This study specifically addresses issue torsional movement detection during patient positioning. Non-invasive torsion is performed by measuring iris pattern rotations using a beams view camera. When handling images to be treated therapy, number additional challenges...
Optical eye tracking solutions can play a role in patient alignment and real-time monitoring of the movements during ocular proton therapy (OPT) replace current clinical standard based on radiographic imaging surgical clips implanted patient's eye. The aim this study is to compare performance an solution specifically developed for OPT applications standard. system (ETS) was used pre-align treatment position using information solely pupil before correction administered through X-ray imaging....
Purpose or Objective: An electromagnetic (ELM) system (Calypso, Varian Medical System, Palo Alto, CA, USA) based on sub-millimeter high frequency localization of three transponders permanently implanted in the prostate, was recently introduced for continuous real-time tracking tumor.Several studies tracks acquired over thousands patients were reported literature and allowed to give a detailed insight intra-fraction prostate motion.Aim this work develop validate tool selectively filter signal...
Correlation of the translation with rotation may be used to optimize targeting accuracy marker based liver SBRT.Possible optimization includes setup 6D couch corrections, treatment margins aligned preferred directions motion, and adaptive techniques such as MLC tracking that can compensate for both translations rotations during treatment.