A5056618793- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Radiation Effects in Electronics
- Nuclear Physics and Applications
- Radiation Effects and Dosimetry
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Delphi Technique in Research
- Boron Compounds in Chemistry
- Advanced Power Generation Technologies
- Systemic Sclerosis and Related Diseases
- Nuclear reactor physics and engineering
- Magnetic and Electromagnetic Effects
- Electron and X-Ray Spectroscopy Techniques
- Industrial Gas Emission Control
- Field-Flow Fractionation Techniques
- Chemical Reactions and Isotopes
- Photocathodes and Microchannel Plates
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Catalysis and Hydrodesulfurization Studies
- Advanced MRI Techniques and Applications
Paul Scherrer Institute
2019-2025
Proton (Malaysia)
2023
Klinikum rechts der Isar
2014-2016
München Klinik
2016
Technical University of Munich
2016
We investigated the effect of proton FLASH radiation on plasmid DNA. Purified supercoiled pBR322 plasmids were irradiated with clinical doses (≤10 Gy) protons at ultra-high and conventional dose rates using Paul Scherrer Institute (PSI) isochronous cyclotron. The beam in this facility has been validated to produce preclinical models. Plasmid samples under various oxygen tensions, scavenger levels, pH conditions Fe (II) concentrations as these biochemical parameters vary across tissues...
The response of Al2O3:C optically stimulated luminescence detectors (OSLDs) was investigated in a 250 MeV pencil proton beam. OSLD mapped for wide range average dose rates up to 9000 Gy s-1, corresponding ∼150 kGy s-1instantaneous rate each pulse. Two setups ultra-high (FLASH) experiments are presented, which enable OSLDs or biological samples be irradiated either water-filled vials cylinders. were found independent all rates, with an deviation <1% relative the nominal (1-1000) s-1when two...
Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting former clinical pencil beam scanning gantry irradiations ultrahigh dose rates. Methods: PSI Gantry 1 treated patients until December 2018. We optimized the beamline parameters transport 250 MeV extracted from COMET accelerator treatment room, maximizing transmission intensity sample. characterized monitor on ensure good control dose, delivered in spot-scanning mode. different...
The physico-chemical and biological response to conventional UHDR electron proton beams was investigated, along with photons. temporal structure nature of the beam affected both, at ≥1400 Gy/s 0.1 1260 found be isoefficient sparing zebrafish embryos.
The FLASH effect has been validated in different preclinical experiments with electrons (eFLASH) and protons (pFLASH) operating at an average dose rate above 40 Gy/s. However, no systematic intercomparison of the produced by eFLASHvs. pFLASH yet performed constitutes aim present study.
Objective.This work aims at characterizing LiF:Mg,Ti thermoluminescence detectors (TLDs) for dosimetry of a 250 MeV proton beam delivered ultra-high dose rates (UHDR). Possible rate effects in LiF:Mg,Ti, as well its usability narrow beams are investigated.Approach.LiF:Mg,Ti (TLD-100TMMicrocubes, 1 mm × mm) was packaged matrices 5 detectors. The center each matrix irradiated with single-spot low-LET (energy >244 MeV) the (1-4500) Gy s-1average range. A reconstruction procedure applied to...
Purpose To demonstrate the suitability of optically stimulated luminescence detectors (OSLDs) for accurate simultaneous measurement absolute point dose and dose-weighted linear energy transfer (LET D ) in an anthropomorphic phantom experimental validation daily adaptive proton therapy. Methods A clinically realistic intensity-modulated therapy (IMPT) treatment plan was created based on a CT head-and-neck made tissue-equivalent material. The IMPT optimized with three fields to deliver uniform...
Abstract The objective of this study was to improve the precision linear energy transfer (LET) measurements using $$\text {Al}_2\text {O}_3\text {:C}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mtext>Al</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> <mml:mtext>O</mml:mtext> <mml:mn>3</mml:mn> <mml:mtext>:C</mml:mtext> </mml:mrow> </mml:math> optically stimulated luminescence detectors (OSLDs) in proton beams, and, with that, OSL dosimetry by correcting...
The objective of this work is to demonstrate that MgB4O7:Ce,Li, a new optically stimulated luminescence (OSL) dosimetric material, shows improved response for proton therapy dosimetry, with less reduction in detector efficiency the particle linear energy transfer (LET). MgB4O7:Ce,Li was synthesized and its as function LET characterized dose-averaged values from 0.73 keV/μm up 74.9 using proton, 4He, 12C ion beams. Commercial Al2O3:C OSLDs were also used comparison. Monte Carlo simulations...
Objective.This work investigates the use of Al2O3:C and Al2O3:C,Mg optically stimulated luminescence (OSL) detectors to determine both dose radiation quality in light ion beams. The is here expressed through either linear energy transfer (LET) or closely related metricQeff, which depends on particle's speed effective charge. derived LET andQeffvalues are applied improve dosimetry beams.Approach.OSL were irradiated mono-energetic1H-,4He-,12C-, and16O-ion OSL signal associated with two...
Research on ultra-high dose rate (UHDR) radiation therapy has indicated its potential to spare normal tissue while maintaining equivalent tumor control compared conventional treatments. First clinical trials are underway. The randomized phase II/III FEATHER trial at the Paul Scherrer Institute in collaboration with University of Zurich Animal Hospital is one first curative domestic animal be attempted, and it designed provide a good example for human trials. However, lack standardized...
Recently, proton therapy treatments delivered with ultra-high dose rates have been of high scientific interest, and the Faraday cup (FC) is a promising dosimetry tool for such experiments. Different institutes use different FC designs, either voltage guard ring, or combination an electric magnetic field employed to minimize effect secondary electrons. The authors first investigate these approaches beam energies 70, 150, 230 250 MeV, fields between 0 24 mT voltages -1000 1000 V. When applying...
Abstract Purpose Energy changes in pencil beam scanning proton therapy can be a limiting factor delivery time, hence, patient throughput and the effectiveness of motion mitigation techniques requiring fast irradiation. In this study, we investigate feasibility performing continuous energy modulation within momentum acceptance clinical beamline for therapy. Methods The alternative use local degrader at gantry coupling point has been compared with more common upstream regulation. Focusing on...
We present the commissioning and quality assurance of our clinical protocol for respiratory gating in pencil beam scanning proton therapy cancer patients with moving targets. In a novel approach, optical tracking has been integrated workflow used to monitor motion from multiple surrogates, applied on patients' chest. The system was tested under variety experimental conditions, specific therapy, evaluate reaction time reproducibility dose delivery control. proved be precise application...
The FLASH effect has been validated in different preclinical experiments with electrons (eFLASH) and protons (pFLASH) operating at a mean dose rate above 40 Gy/s. However, no systematic intercomparison of the produced by e
Beam energy validation is a fundamental aspect of the routine quality assurance (QA) protocol particle therapy facility. A multilayer ionization chamber (MLIC) detector provides optimal tradeoff between achieving accuracy in range determination and saving operational time measurements analysis procedures. We propose characterization commercial MLIC as suitable QA tool for clinical environment with proton carbon-ion scanning beams.Commercial Giraffe (IBA Dosimetry, Schwarzenbruck, Germany)...
The Pencil Beam Scanning (PBS) technique in proton therapy uses fast magnets to scan the tumor volume rapidly. Changing energy allows changing layers third dimension, hence scanning same several times. PBS approach permits adapting speed and/or current modulate delivered dose. We built a simple prototype that measures dose distribution single step. active detection material consists of layer scintillating fibers (i.e., 1D) with an length 100 mm, width 18.25 and insignificant space (20 μm)...
Purpose: To characterize a new air vented ionization chamber technology, suitable to build detector arrays with small pixel pitch and independence of sensitivity on dose per pulse. Methods: The prototype under test is linear array chambers, consisting 80 pixels 3.5 mm distance sensitive volume about 4 mm3. has been characterized 60Co radiation MV x rays from different accelerators (with flattened unflattened beam qualities). Sensitivity dependence pulse evaluated by changing both the source...
Experiments with ultra-high dose rates in proton therapy are of increasing interest for potential treatment benefits. The Faraday Cup (FC) is an important detector the dosimetry such rate beams. So far, there no consensus on optimal design a FC, or influence beam properties and magnetic fields shielding FC from secondary charged particles.To perform detailed Monte Carlo simulations cup to identify quantify all charge contributions primary protons particles that modify efficiency response as...