A5036263694- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Multisensory perception and integration
- Noise Effects and Management
- Vestibular and auditory disorders
- Neuroscience and Neural Engineering
- Speech and Audio Processing
- Acoustic Wave Phenomena Research
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Tactile and Sensory Interactions
- Reading and Literacy Development
- Color perception and design
- Educational Games and Gamification
- Photoreceptor and optogenetics research
- Bat Biology and Ecology Studies
- Marine animal studies overview
- Olfactory and Sensory Function Studies
- Plant Physiology and Cultivation Studies
- Memory and Neural Mechanisms
- Cognitive and developmental aspects of mathematical skills
- Sleep and Wakefulness Research
- Video Analysis and Summarization
Newcastle University
2015-2024
Offenburg University of Applied Sciences
2017-2019
Manchester Metropolitan University
2018
Universidad Nacional Autónoma de México
2014
University of Newcastle Australia
2010
University of Sunderland
2008
KU Leuven
2004
University of Manchester
1993
MRC Institute of Hearing Research
1988-1990
University of Nottingham
1990
The relationship between sensory sensitivity and reading performance was examined to test the hypothesis that orthographic phonological skills engaged in visual word recognition are constrained by ability detect dynamic auditory events. A battery using psychophysics, psychometric tests, measures of component literacy administered 32 unselected 10-year-old primary school children. results suggest children's both stimuli related their skills. Importantly, after controlling for intelligence...
Abstract We present a comprehensive description of the local (intrinsic and commissural) connections in central nucleus inferior colliculi (CNICs) guinea pig. Focal injections anterograde tracer biocytin were made into physiologically identified loci CNIC spatial organisation labeled fibres was revealed with computer‐assisted threedimensional (3‐D) reconstruction. The intrinsic form series V‐shaped laminar plexuses composed bearing both terminal en passant boutons. Each plexus has wing...
1. To determine the contribution of inhibition to generation temporal response patterns neurons in inferior colliculus (IC), effects iontophoretically applied gamma-aminobutyric acid (GABA), glycine, and GABAA glycine receptor antagonists, bicuculline strychnine were studied on 121 IC urethan-anesthetised guinea pig. 2. The discharge classified into six categories basis their peristimulus time histograms (PSTHs). 1) Onset units fired at stimulus onset could be divided two subtypes: narrow...
Neuronal responses were recorded to pure and sinusoidally amplitude-modulated (AM) tones at the characteristic frequency (CF) in central nucleus of inferior colliculus anesthetized guinea pigs. Temporal (synchronized) mean-rate measures derived from period histograms locked stimulus modulation waveform characterize response. For stimuli presented quiet, gain low frequencies (approx less than 50 Hz) was inversely proportional neuron's mean firing rate response both modulated a tone an...
The processing of biologically important sounds depends on the analysis their frequency content by cochlea and CNS. GABAergic inhibition in inferior colliculus shapes response areas echolocating bats, but a similar role nonspecialized mammals has been questioned. We used powerful combination iontophoresis with detailed to test hypothesis that glycinergic operating mammal (guinea pig) shape responses neurons this nucleus. Our reveals two groups colliculus: V-shaped non-V-shaped. as function...
Heteroplasmic mitochondrial DNA (mtDNA) defects are an important cause of neurological disease. Although hearing impairment is common in patients with mtDNA defects, the spectrum and pathophysiology loss not well characterized. We therefore studied relationship between cochlear brainstem auditory function 23 harbouring a range different mutations. Based upon pure tone audiogram, fell into three distinct groups: (i) normal hearing, (ii) mild to moderate predominantly high frequency loss,...
This work tests the hypothesis that a network of areas involving bilateral premotor cortex and right parietal subserves analysis sound movement. The components this have been examined at level individual subjects in study where 720 fMRI scans were acquired per subject. Additionally, effect movement direction was investigated by varying property systematically. Linear ramps are perceived as toward one side head or other used an experiment which principal contrast between movement, stationary...
Rees, Adrian, Ali Sarbaz, Manuel S. Malmierca, and Fiona E. N. Le Beau. Regularity of firing neurons in the inferior colliculus. J. Neurophysiol. 77: 2945–2965, 1997. The spike discharge regularity 254 tonically units colliculus (IC) anesthetized guinea pig was studied response to tones presented at best frequency (BF) ear contralateral recorded IC. measured by calculating coefficient variation (CV) as a function time over course unit's response. Two hundred fifteen (56 under urethan 159...
Key points Neurons in the auditory midbrain, inferior colliculus, are selectively sensitive to combinations of sound frequency and level as illustrated by their frequency/level receptive fields. Different field shapes have been described, but we do not know if these represent discrete classes reflecting afferent inputs from individual sources, or a more complex pattern integration. In this study used objective methods analyse fields over 2000 neurons guinea pig colliculus. Subjectively...
Abstract The right and left inferior colliculi (ICs) in the auditory midbrain are connected to one another by a bundle of fibres, commissure IC. Previous studies show that this commissural projection connects corresponding frequency regions two sides originates mainly from excitatory neurons, although some suggest smaller number GABAergic inhibitory neurons may also project via commissure. Although IC is major pathway connecting most important nuclei tectum, little known about its functional...
Rate-intensity functions (RIFs) were generated in response to characteristic frequency (CF) tones presented alone and the presence of broadband noise for neurons central nucleus inferior colliculus (IC) anesthetized guinea pig. Seventy-six percent RIFs CF monotonic (some showing incomplete saturation), 24% nonmonotonic. The continuous more nonmonotonic than those tones. In or gated noise, dynamic portion RIF a tone was shifted higher level, with little change range. Above threshold shift...