A5016975533- Nerve injury and regeneration
- Myasthenia Gravis and Thymoma
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Collagen: Extraction and Characterization
- Silk-based biomaterials and applications
- Multiple Sclerosis Research Studies
- Tendon Structure and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Neuroscience and Neural Engineering
- Axon Guidance and Neuronal Signaling
- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- Cellular Mechanics and Interactions
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Facial Nerve Paralysis Treatment and Research
- Cellular transport and secretion
- Spinal Cord Injury Research
- Lipid Membrane Structure and Behavior
- SARS-CoV-2 and COVID-19 Research
- Orthopedic Surgery and Rehabilitation
- Iron Metabolism and Disorders
- Neurological and metabolic disorders
Wake Forest University
2024
George Washington University
2018-2023
King Hussein Medical Center
2023
Henry Ford Health System
2023
University Medical Center
2023
Jordan University of Science and Technology
2023
University of Kansas Medical Center
2023
St. Elizabeth's Medical Center
2023
Marshall University
2023
University of Houston
2023
<h3>Importance</h3> Many patients with generalized myasthenia gravis (gMG) have substantial clinical disability, persistent disease burden, and adverse effects attributable to chronic immunosuppression. Therefore, there is a significant need for targeted, well-tolerated therapies the potential improve control enhance quality of life. <h3>Objective</h3> To evaluate zilucoplan, subcutaneously (SC) self-administered macrocyclic peptide inhibitor complement component 5, in broad population...
The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure a significant effect efficacy. 3D branched polymeric structures, such as dendrimers, have proved to be very effective for vectors; however, so far the dendritic polymers not delivered promise. This is largely because wide range of polymer materials with tailored multifunctional properties and biocompatibility required applications are yet accessible by...
Astrocytes have been implicated in regulating oligodendrocyte development and myelination vitro, although their functions vivo remain less well defined. Using a novel approach to locally ablate GFAP+ astrocytes, we demonstrate that astrocytes are required for normal CNS myelin compaction during development, maintaining integrity the adult. Transient ablation of mouse spinal cord first postnatal week reduced numbers mature oligodendrocytes inhibited formation, while prolonged resulted lacked...
The development of nerve guidance conduits is constantly evolving as the need arises for therapies spinal cord injury. In addition to providing a path regrowing axons reconnect with their appropriate targets, structural and biochemical cues provided by these should be permissive directional neurite outgrowth protective against inhibition in vicinity injury site. Here, we adapted use iso-electric focusing drive alignment supramolecular fibrils into self-assembled collagen hydrogels (∼300 µm...
Nonviral genetic therapeutic intervention strategies for neurological disorders hold great promise, but a lack of vector efficacy, coupled with toxicity, continue to hinder progress. Here we report the application newly developed class polymer, distinctly different from conventional branched polymers, as transfection agent delivery glial cell line derived neurotrophic factor (GDNF) encoding gene. This new 2-(dimethylamino)ethyl methacrylate (DMAEMA) based cyclized knot polymer was studied...
Background Telemedicine practice for neurological diseases has grown significantly during the COVID-19 pandemic. offers an opportunity to assess digitalization of examinations and enhances access modern computer vision artificial intelligence processing annotate quantify in a consistent reproducible manner. The Myasthenia Gravis Core Examination (MG-CE) been recommended telemedicine evaluation patients with myasthenia gravis. Objective We aimed ability take accurate robust measurements...
Due to the precautions put in place during COVID-19 pandemic, utilization of telemedicine has increased quickly for patient care and clinical trials. Unfortunately, teleconsultation is closer a video conference than medical consultation, with current solutions setting doctor into an evaluation that relies entirely on two-dimensional view each other. We are developing patented telehealth platform assists diagnostic testing ocular manifestations myasthenia gravis. present hybrid algorithm...
In this article, we discuss the clinical approach to patients with dropped head syndrome and identify various neuromuscular causes of syndrome, including muscle, junction, peripheral nerve, motor neuron etiologies. We aim increase awareness recognition entity factors that may predict responses immunomodulating therapy.
Patients with sickle cell disease (SCD) are prone to symptomatic neurologic complications. Previous studies reported accrual of neural injury starting at early age, even without having events. The aim this study was assess the prevalence and risk factors abnormal findings in patients SCD no history major
Abstract Background During nerve growth, cytoplasmic vesicles add new membrane preferentially to the growth cone located at distal tip of extending axons. Growth is also retrieved locally, and asymmetric retrieval facilitates remodeling during repulsion by a chemorepellent gradient. Moreover, inhibitory factors can stimulate bulk induce collapse. Despite these functional insights, processes mediating local axon extension remain poorly defined. Results To investigate spatial temporal dynamics...