A5003768477- Evolution and Paleontology Studies
- Genomics, phytochemicals, and oxidative stress
- Light effects on plants
- Sulfur Compounds in Biology
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Glutathione Transferases and Polymorphisms
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Adipose Tissue and Metabolism
- Morphological variations and asymmetry
- Plant Gene Expression Analysis
- Heat shock proteins research
- Effects and risks of endocrine disrupting chemicals
- Diet and metabolism studies
- Genetic Syndromes and Imprinting
- Genetics, Aging, and Longevity in Model Organisms
- Adenosine and Purinergic Signaling
- Isotope Analysis in Ecology
- Maritime and Coastal Archaeology
- Urban and spatial planning
- Dermatology and Skin Diseases
- Mycotoxins in Agriculture and Food
- Dietary Effects on Health
- Hair Growth and Disorders
University of Memphis
2010-2019
University of Tennessee Health Science Center
2018
University of Pittsburgh
2018
Johns Hopkins University
2018
Center for Genomic Science
2017
Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet responsible mechanisms are not well understood. We show here that chemical activation NRF2 modifies gene expression and rhythmicity, phenotypes similar genetic activation. Loss Nrf2 function in mouse fibroblasts, hepatocytes liver also altered rhythms, suggesting stoichiometry and/or timing important timekeeping some cells. Consistent this concept, at a time corresponding peak...
Chloracne is commonly observed in people exposed to dioxins, yet the mechanism of toxicity not well understood. The pathology chloracne characterized by hyperkeratinization interfollicular squamous epithelium, hyperproliferation and hair follicle cells as a metaplastic response ductular sebum secreting sebaceous glands. In vitro studies using normal human epidermal keratinocytes model epidermis demonstrate 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated acceleration differentiation...
Abstract In experimental animals and humans, aflatoxin B1 (AFB1) is a potent hepatic toxin carcinogen. The synthetic oleanane triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im), powerful activator of Keap1-Nrf2 signaling, protects against AFB1-induced toxicity preneoplastic lesion formation (GST-P–positive foci). This study assessed mechanistically characterized the chemoprotective efficacy CDDO-Im hepatocellular carcinoma (HCC). A lifetime cancer bioassay was...
The unique biophysical and electronic properties of cysteine make this molecule one the most biologically critical amino acids in proteome. defining sulfur atom is much larger than oxygen nitrogen atoms more commonly found other acids. As a result its size, valence electrons are highly polarizable. Unique protein microenvironments favor polarization sulfur, thus increasing overt reactivity cysteine. Here, we provide brief overview endogenous generation reactive electrophilic species specific...
The Kelch-like erythroid-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway is the subject of several clinical trials evaluating effects Nrf2 activation on prevention cancer and diabetes treatment chronic kidney disease multiple sclerosis. 3
Obesity is a growing epidemic worldwide leading to rates of chronic disease and diabetes. A diet rich in omega‐6 fatty acids refined sugars, known as the “Western diet,” may be one contributing factor. Prevention weight gain, well loss, have been shown beneficial preventing obesity‐associated disease. Growing evidence suggests that fasting reliable method aid loss prevention gain. Although effective reducing fat mass, there risk losing lean muscle. There are many different types fasting,...