A5057275199- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Poisoning and overdose treatments
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Neurotransmitter Receptor Influence on Behavior
- Opioid Use Disorder Treatment
- Plant-based Medicinal Research
- Prenatal Substance Exposure Effects
- Pesticide Residue Analysis and Safety
- Plant Toxicity and Pharmacological Properties
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Antibiotics Pharmacokinetics and Efficacy
- Muscle metabolism and nutrition
- Plant-Derived Bioactive Compounds
- Epilepsy research and treatment
- Hormonal and reproductive studies
- Steroid Chemistry and Biochemistry
- Traditional and Medicinal Uses of Annonaceae
- Veterinary Pharmacology and Anesthesia
- Attention Deficit Hyperactivity Disorder
Marche Polytechnic University
2020-2024
Sapienza University of Rome
2019-2022
Ospedali Riuniti di Ancona
2022
Hôpital Paule de Viguier
2021
National Institute on Drug Abuse
2015-2020
National Institutes of Health
2015-2020
Université Claude Bernard Lyon 1
2014
Fraunhofer Institute for Toxicology and Experimental Medicine
2014
Marie Curie
2014
École Normale Supérieure - PSL
2014
Abstract Following isotonitazene scheduling in 2019, the availability of alternative 2-benzylbenzimidazole opioids (nitazenes) on global drug market increased, resulting many fatalities worldwide. Nitazenes are potent µ-opioid receptor agonists with strong narcotic/analgesic effects, and their concentrations biological matrices low, making detection metabolite biomarkers consumption crucial to document use clinical forensic settings. However, there is little no data metabolism most recently...
In 2023, hexahydrocannabinol (HHC) attracted the attention of international agencies due to its rapid spread in illegal market. Although it was discovered 1940, less is known about pharmacology two naturally occurring epimers, 9(R)-HHC and 9(S)-HHC. Thus, we aimed investigate disposition epimers their metabolites whole blood, urine oral fluid following a single controlled administration 50:50 mixture 9(S)-HHC smoked with tobacco. To this end, six non-user volunteers 25 mg HHC 500 Blood were...
Abstract Objectives N-piperidinyl etonitazene (etonitazepipne) is a newly synthesized opioid related to the 2-benzylbenzimidazole analog class. Etonitazepipne has been formally notified and placed under intensive monitoring in Europe January 2022. Nitazenes have high affinity at µ-opioid receptor (MOR). Etonitazepipne, specifically shows EC 50 of 2.49 nM, suggesting about times higher potency combined with efficacy compared morphine. Antinociceptive l (‘hot plate test’ rats) was 192-fold...
Recently, synthetic opioid-related overdose fatalities, led by illicitly manufactured fentanyl and analogs, increased at an alarming rate, posing a global public health threat. New analogs have been constantly emerging onto the drug marked for last few years, to circumvent laws avoid analytical detection. Analytical methods need be regularly updated keep up with new trends. In this study, we aimed develop method detecting newest high sensitivity, in whole blood, urine, hair. The is intended...
ADB-PINACA and its 5-fluoropentyl analog 5F-ADB-PINACA are among the most potent synthetic cannabinoids tested to date, with several severe intoxication cases. have a different legal status, depending on country. Synthetic cannabinoid metabolites predominate in urine, making detection of specific reliable way for proving intake clinical forensic specimens. However, there currently no data 5F-PINACA metabolism. The substitution single fluorine atom distinguishes 2 molecules, which may share...
Metabolite profiling of novel psychoactive substances (NPS) is critical for documenting drug consumption. N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (ADB-FUBINACA) an emerging synthetic cannabinoid whose toxicological and metabolic data are currently unavailable. We aimed to determine optimal markers identifying ADB-FUBINACA intake. Metabolic stability was evaluated with human liver microsome incubations. Metabolites were identified after 1 3 h...
25C-NBOMe and 25I-NBOMe are potent hallucinogenic drugs that recently emerged as new psychoactive substances. To date, a few metabolism studies were conducted for 25I-NBOMe, whereas data scarce. Therefore, we investigated the metabolic profile of these compounds in human hepatocytes, an vivo mouse model authentic urine samples from forensic cases. Cryopreserved hepatocytes incubated 3 h with 10 μM 25I-NBOMe; analyzed by liquid chromatography high-resolution mass spectrometry (LC-HRMS) on...
OPINION article Front. Psychiatry, 23 October 2020Sec. Addictive Disorders Volume 11 - 2020 | https://doi.org/10.3389/fpsyt.2020.584462
Recently, hexahydrocannabinol (HHC) was posed under strict control in Europe due to the increasing HHC-containing material seizures. The lack of analytical methods clinical laboratories detect HHC and its metabolites biological matrices may result related intoxication underreporting. We developed validated a comprehensive GC-MS/MS method quantify 9(R)-HHC, 9(S)-HHC, 9αOH-HHC, 9βOH-HHC, 8(R)OH-9(R)-HHC, 8(S)OH-9(S)HHC, 11OH-9(R)HHC, 11OH-9(S)HHC, 11nor-carboxy-9(R)-HHC, 11nor-carboxy-9(S)-HHC...
Background: Little or no pharmacological toxicological data are available for novel psychoactive substances when they first emerge, making their identification and interpretation in biological matrices challenging. Materials & methods: A new synthetic cathinone, α-pyrrolidinopentiothiophenone (α-PVT), was incubated with hepatocytes samples were analyzed using liquid chromatography coupled to a Q ExactiveTM Orbitrap mass spectrometer. Authentic urine specimens from suspected α-PVT cases also...
Pregabalin is a drug for treating epilepsy, anxiety disorders and neuropathic pain. Cases of poisoning are rare, though some have been fatal. Concentrations pregabalin in postmortem human samples its distribution very rarely documented. As the literature so scarce, we propose to report concentrations autopsy 18 people who had taking Lyrica(®), including one case mixed overdose involving pregabalin. Analysis was carried out using an original Hydrophilic Interaction LIquid Chromatography...