A5000481023- Gene Regulatory Network Analysis
- Neural dynamics and brain function
- Complex Network Analysis Techniques
- Superconducting Materials and Applications
- stochastic dynamics and bifurcation
- Slime Mold and Myxomycetes Research
- Advanced Memory and Neural Computing
- Neural Networks and Applications
- Electrochemical Analysis and Applications
- Physics of Superconductivity and Magnetism
- Bioinformatics and Genomic Networks
- Particle accelerators and beam dynamics
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Mathematical Biology Tumor Growth
- FOXO transcription factor regulation
- Game Theory and Applications
- Phytochemicals and Medicinal Plants
- Opinion Dynamics and Social Influence
- Banking Systems and Strategies
- Terahertz technology and applications
- Advanced Fluorescence Microscopy Techniques
- Integrated Circuits and Semiconductor Failure Analysis
- Probabilistic and Robust Engineering Design
- Nerve injury and regeneration
RWTH Aachen University
2018-2024
Institute for Advanced Study
2018-2020
Forschungszentrum Jülich
2018
Jülich Aachen Research Alliance
2018
Annamalai University
2013
Lawrence Berkeley National Laboratory
2010-2012
University of California, Berkeley
2010-2012
In the past two years US LARP program carried out five tests on a quadrupole magnet aimed at high luminosity upgrade of Large Hadron Collider (HiLumi-LHC). The 1-meter long, 120 mm bore IR (HQ) with short sample gradient 219 T/m 1.9 K and conductor peak field 15 T is part LHC Accelerator Research Program (LARP). series tests, 4.4 K, reached maximum "short-sample" performance 86%. exposed several shortcomings that are now being addressed in & Development program. This paper summarizes test...
Abstract Making high-quality dopamine (DA)-producing cells for basic biological or small molecule screening studies is critical the development of novel therapeutics disorders ventral midbrain. Currently, many midbrain assays have low signal-to-noise ratio due to levels cellular DA and rate-limiting enzyme synthesis, tyrosine hydroxylase (TH), hampering discovery efforts. Using intensively characterized derived from human skin, which demonstrate calcium pacemaking activity classical...
Abstract The central question of systems biology is to understand how individual components a biological system such as genes or proteins cooperate in emerging phenotypes resulting the evolution diseases. As living cells are open quasi-steady state type equilibrium continuous exchange with their environment, computational techniques that have been successfully applied statistical thermodynamics describe phase transitions may provide new insights behavior systems. Here we systematically...
Heterozygous loss-of-function mutations in Forkhead box G1 (FOXG1), a uniquely brain-expressed gene, cause microcephaly, seizures, and severe intellectual disability, whereas increased FOXG1 expression is frequently observed glioblastoma. To investigate the role of forebrain cell proliferation, we modeled syndrome using cells from three clinically diagnosed cases with two sex-matched healthy parents one unrelated control. Cells heterozygous loss showed significant reduction ratio G0/G1 stage...
Spiking neuronal networks are usually simulated with three main simulation schemes: the classical time-driven and event-driven schemes, more recent hybrid scheme. All schemes evolve state of a neuron through series checkpoints: equally spaced in first scheme determined neuron-wise by spike events latter two. The determine whether membrane potential crosses threshold at end time interval between consecutive checkpoints. Threshold crossing can, however, occur within even if this test is...
The development of computational models representing Rutherford cable formation and deformation is necessary to investigate the strain state in superconducting filaments Nb3Sn magnets. wide variety length scales within accelerator magnets suggests usage a hierarchical structure model. As part an ongoing investigation at LBNL, three-dimensional simplified nonlinear multiscale model developed as way extend previous linear elastic versions. inclusion plasticity into problem formulation allows...
Abstract: In the ever-evolving realm of urban transportation, fusion technological advancements and ubiquitous mobile connectivity has sparked a paradigm shift in how cities are navi- gated. This led to innovative approaches ridesharing crowdsourcing, offering promising solutions tackle traffic congestion, reduce emissions, prioritize travel needs urbanareas. Unlike traditional carpooling methods, where arrange-ments made advance, smart operates on real-time matching drivers riders, with...
Amperometry is a commonly used electrochemical method for studying the process of exocytosis in real-time. Given high precision recording that amperometry procedures offer, volume data generated can span over several hundreds megabytes to few gigabytes and therefore necessitates systematic reproducible methods analysis. Though spike characteristics traces time domain hold information about dynamics exocytosis, these biochemical signals are, more often than not, characterized by time-varying...
Elucidating exocytosis processes provides insights into cellular neurotransmission mechanisms and may have potential in research on neurodegenerative diseases. Amperometry is an established electrochemical method for detection of neurotransmitters released from stored inside cells. An important aspect the amperometry sub-millisecond temporal resolution current recordings which usually leads to several hundreds gigabytes high-quality data. In this study, we present a universal classification...
Abstract The concept of attractor dynamic biochemical networks has been used to explain cell types and alterations in health disease. We have recently proposed an extension the notion take into account metastable regimes, defined as long lived dynamical states network. These regimes correspond slow dynamics on low dimensional invariant manifolds networks. Methods based tropical geometry allow compute represent them polyhedra space logarithms species concentrations. are looking for sensitive...
The large range of length scales present within accelerator magnets suggests the incorporation a hierarchical structure into computational models. Evaluation strain state superconducting filaments is necessary in order to determine critical current Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn based magnets. As part an ongoing investigation at LBNL, three-dimensional nonlinear multiscale model developed investigate behavior...
Networks that have power-law connectivity, commonly referred to as the scale-free networks, are an important class of complex networks. A heterogeneous mean-field approximation has been previously proposed for Ising model Barabási-Albert networks with classical spins on nodes wherein it was shown critical temperature such a system scales logarithmically network size. For finite sizes, there is no criticality and hence true phase transition in terms singular behavior. Further, thermodynamic...
Elucidating exocytosis processes provide insights into cellular neurotransmission mechanisms, and may have potential in neurodegenerative diseases research. Amperometry is an established electrochemical method for the detection of neurotransmitters released from stored inside cells. An important aspect amperometry sub-millisecond temporal resolution current recordings which leads to several hundreds gigabytes high-quality data. In this study, we present a universal classification with...
Amperometry is a commonly used electrochemical method for studying the process of exocytosis in real-time. Given high precision recording that amperometry procedures offer, volume data generated can span over several hundreds megabytes to few gigabytes and therefore necessitates systematic reproducible methods analysis. Though spike characteristics traces time domain hold information about dynamics exocytosis, these biochemical signals are, more often than not, characterized by time-varying...
The central question of systems biology is to understand how individual components a biological system such as genes or proteins cooperate in emerging phenotypes resulting the evolution diseases. As living cells are open quasi-steady state type equilibrium continuous exchange with their environment, computational techniques that have been successfully applied statistical thermodynamics describe phase transitions may provide new insights behavior systems. Here we will systematically evaluate...