A5075239608- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Genomics and Chromatin Dynamics
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Muscle Physiology and Disorders
- vaccines and immunoinformatics approaches
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
Biomedical Research Foundation of the Academy of Athens
2024-2025
Academy of Athens
2020-2024
National and Kapodistrian University of Athens
2021-2024
Generation of induced pluripotent stem cells from specialized cell types provides an excellent model to study how maintain their stability, and they can change identity, especially in the context disease. Previous studies have shown that chromatin safeguards identity by acting as a barrier reprogramming. We investigated mechanisms which histone macroH2A variants inhibit reprogramming discovered work gate keepers mesenchymal state blocking epithelial transition, step required for mouse...
Cellular reprogramming of somatic cells towards induced pluripotency is a multistep stochastic process mediated by the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM), which orchestrate global epigenetic transcriptional changes. We performed large-scale analysis integrated ChIP-seq, ATAC-seq RNA-seq data revealed spatiotemporal highly dynamic pattern OSKM DNA binding during reprogramming. found that show distinct temporal patterns to different classes pluripotency-related enhancers....
Cellular reprogramming of somatic cells towards induced pluripotency is a multistep stochastic process mediated by the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM), which orchestrate global epigenetic transcriptional changes. We performed large-scale analysis integrated ChIP-seq, ATAC-seq RNA-seq data revealed spatiotemporal highly dynamic pattern OSKM DNA binding during reprogramming. found that show distinct temporal patterns to different classes pluripotency-related enhancers....
Members of the α-thymosin family have long been studied for their immunostimulating properties. Among them, danger-associated molecular patterns (DAMPs) prothymosin α (proTα) and its C-terminal decapeptide proTα(100-109) shown to act as immunomodulators in vitro, due ability promote T helper type 1 (Th1) responses. Recently, we verified these findings vivo, showing that both proTα enhance antitumor-reactive cell-mediated responses.In view eventual use humans, investigated safety profile...