A5034302686- Dendrimers and Hyperbranched Polymers
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- biodegradable polymer synthesis and properties
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- Fungal and yeast genetics research
- Advanced Drug Delivery Systems
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Antimicrobial agents and applications
- Carbon dioxide utilization in catalysis
- X-ray Diffraction in Crystallography
- Protein Degradation and Inhibitors
- Fuel Cells and Related Materials
- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Endoplasmic Reticulum Stress and Disease
- Polydiacetylene-based materials and applications
- Ferrocene Chemistry and Applications
- Microbial Metabolic Engineering and Bioproduction
- Crystallization and Solubility Studies
- Biofuel production and bioconversion
University of Birmingham
2019-2024
Loughborough University
2024
University of Nottingham
2017-2023
South Australian Research and Development Institute
2022
Park University
2019
The University of Queensland
2014-2017
Engineering and Physical Sciences Research Council
2017
ARC Centre of Excellence in Advanced Molecular Imaging
2016
Mary Lyon Centre at MRC Harwell
2001-2005
University of Aberdeen
2001
Over the past few decades, advanced polymeric materials have gained popularity in development of sustainable agricultural applications. Smart systems extensively contributed to industry by increasing efficiency pesticides, herbicides, and fertilizers facilitating controlled release and, therefore, enabling lower doses be used. Superabsorbent been used as soil conditioners control impact drought, whereas polycationic polymers utilized for plant bioengineering. These functions environment are...
The past decades have seen significant research effort in the field of polymers for a range biomedical applications, driven by promising prospect these materials realizing next generation therapeutics clinic. In this regard, it is widely accepted that polymer properties such as chemistry, charge, and block composition, well their self-assemblies including size, shape, surface biodegradation, all influence direct interactions with cells biological membranes. particular, hydrophobicity...
Abstract Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas infection, neurodegeneration, and oncology. Advances have been made treating these diverse pathologies but there still remain many challenging areas. Amongst most difficult are those involving highly potent and/or cytotoxic agents which present inherent problem adverse off‐target effects. Of key to widen window for such by reducing access non‐diseased cells enhancing...
The seemingly simple notion of the hydrophobic effect can be viewed from multiple angles involving theory, simulation, and experiments. This viewpoint examines five attributes predictive models to enhance synthetic efforts as well experimental methods quantify hydrophobicity. In addition, we compare existing against data for polymer surface tension, lower critical solution temperature, self-assembly morphology, degradation behavior. Key conclusions suggest that both Hildebrand solubility...
ABSTRACT Entropy‐driven ROMP (ED‐ROMP) involves polymerization of olefin‐containing macrocyclic monomers under entropically favorable conditions. Macrocycles can be prepared from a variety interesting molecules which, when polymerized, impart unique functionality to the resulting polymer backbone such as degradable linkages, biological moieties, crystallizable groups, or supramolecular hosts. In addition, sequence atoms in cyclic monomer is preserved within repeating units, allowing for...
Theranostics offers an improved treatment strategy for prostate cancer by facilitating simultaneous targeting of tumour cells with subsequent drug delivery and imaging. In this report we describe the synthesis hyperbranched polymers that are biocompatible, can specifically target be internalised (through prostate-specific membrane antigen – PSMA) ultimately facilitate controlled a model drug. The theranostic also incorporates far-red fluorescent dye allows tracking polymer via optical...
Targeted nanomedicines offer a strategy for greatly enhancing accumulation of therapeutic within specific tissue in animals. In this study, we report on the comparative targeting efficiency toward prostate-specific membrane antigen (PSMA) number different ligands that are covalently attached by same chemistry to polymeric nanocarrier. The included small molecule (glutamate urea), peptide ligand, and monoclonal antibody (J591). A hyperbranched polymer (HBP) was utilized as nanocarrier...
Polymerization-induced self-assembly (PISA) is a versatile and readily accessible method to produce nanoparticles of various morphologies in situ as polymerization progresses. PISA exploits the chain extension solvophilic macromolecular chain-transfer agent with monomers that are miscible continuous phase but form solvophobic, immiscible polymer, driving self-assembly. However, ability monitor onset evolution morphology during process remains significant challenge, which critically limits...
Abstract Herein, a library of trifluoroethyl substituted aminomaleimide derivatives are reported with small size and enhanced emissions in both solution solid‐state. A diCH 2 CF 3 aminochloromaleimide exhibits the most efficient dual‐state emission ( Φ f >50 % solid‐state), reduced quenching from protic solvents. This is attributed to reduction electron density on maleimide ring suppressed π‐π stacking mechanism was explored in‐depth by crystallographic analysis, modelling electronic...
Yeast phosphofructo-1-kinase (Pf1k) and pyruvate kinase (Pyk1) are allosterically regulated enzymes that catalyse essentially irreversible reactions in glycolysis. Both the synthesis activity of these tightly regulated. To separate experimentally control Pf1k Pyk1 from their allosteric regulation, a congenic set PFK1, PFK2 PYK1 mutants was constructed which wild-type coding regions were driven by alternative promoters. Mutants carrying PGK1 promoter fusions displayed normal rates growth,...
ABSTRACT The stress-activated protein kinase (SAPK) pathway plays a central role in coordinating gene expression response to diverse environmental stress stimuli. We examined the of this translational Schizosaccharomyces pombe . Exposing wild-type cells osmotic (KCl) resulted rapid but transient reduction synthesis. Protein synthesis was further reduced mutants disrupting SAPK pathway, including mitogen-activated Wis1 or Spc1/Sty1, suggesting for these factors control. Further polysome...
The choice of the polymerisation temperature and initiator in synthesis poly( N -isopropylacrylamide)-based nanogels can significantly influence their structure, morphology thermoresponsive properties.
The development of supramolecular cucurbit[7]uril-based chemosensors for the detection bioanalytes in biofluids such as untreated human serum and inside cells is a challenging task due to competition with proteins inorganic salts. In this contribution, we show that encapsulation polymersomes can prevent deactivation, rendering operational cells. We found hydrophilic poly-[N,N-dimethylacrylamide] corona, especially those smaller than 200 nm, exhibit greater permeability small bioactive...
ABSTRACT The production of well‐defined and reproducible polymeric nanoparticles (NPs), in terms size stability biological environments, is undoubtedly a fundamental challenge the formulation novel more effective nanomedicines. adoption PEGylated lactide (LA) block copolymers as biodegradable biocompatible nanocarriers at different clinical stages has rendered these materials an attractive platform to be exploited their further understood. In present work, we synthesized library linear...
Combination of Doxorubicin with light-regulated NO release achieved through formulation strategy tailored polymeric conjugate nanoparticles may open new treatment modalities to improve cancer therapies.
Abstract Polymer–drug conjugates have received considerable attention over the last decades due to their potential for improving clinical outcomes a range of diseases. It is importance develop methods preparation that simple synthesis and purification requirements but maintain high therapeutic efficacy utilize macromolecules can be cleared via natural excretory pathways upon breakdown. Herein, combination ring‐opening polymerization (ROP) reversible addition−fragmentation chain‐transfer...
Abstract Functional ring‐opening polymerization (ROP) initiators can instill a wide array of chemical, physical, and biological effects into polymeric chain. Highlighting the versatility this “active” initiator approach, broad range characteristics be achieved through use with chemistries spanning from drugs dyes (key in case drug delivery or nanoparticle applications) to radically active monomers, transfer agents, catalysts. The selection suitable (monomers for tandem reactions, dyes,...