A5027115268- Antimicrobial agents and applications
- Bacterial biofilms and quorum sensing
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Lichen and fungal ecology
- Advanced Polymer Synthesis and Characterization
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Nanocomposite Films for Food Packaging
- Analytical chemistry methods development
- Electrochemical sensors and biosensors
- Polymer crystallization and properties
- Additive Manufacturing and 3D Printing Technologies
- Microplastics and Plastic Pollution
- Polymer composites and self-healing
- Central Venous Catheters and Hemodialysis
- Synthesis and properties of polymers
- Marine Biology and Environmental Chemistry
- Antimicrobial Peptides and Activities
- Dental materials and restorations
- Chemistry and Chemical Engineering
- Pharmaceutical and Antibiotic Environmental Impacts
- Surfactants and Colloidal Systems
- Algal biology and biofuel production
- Recycling and Waste Management Techniques
Sapienza University of Rome
2016-2025
Montana State University
2003-2005
Istituto Superiore di Sanità
2001-2004
ABSTRACT In modern medicine, artificial devices are used for repair or replacement of damaged parts the body, delivery drugs, and monitoring status critically ill patients. However, surfaces often susceptible to colonization by bacteria fungi. Once microorganisms have adhered surface, they can form biofilms, resulting in highly resistant local systemic infections. At this time, evidence suggests that (+)-usnic acid, a secondary lichen metabolite, possesses antimicrobial activity against...
ABSTRACT Antibiotic therapies to eradicate medical device-associated infections often fail because of the ability sessile bacteria, encased in their exopolysaccharide matrix, be more drug resistant than planktonic organisms. In last two decades, several strategies prevent microbial adhesion and biofilm formation on surfaces devices, based mainly use antiadhesive, antiseptic, antibiotic coatings polymer surfaces, have been developed. More recent alternative approaches are molecules able...
Scaffolds are three-dimensional porous structures that must have specific requirements to be applied in tissue engineering. Therefore, the study of factors affecting scaffold performance is great importance. In this work, optimal conditions for cross-linking preformed chitosan (CS) scaffolds by tripolyphosphate polyanion (TPP) were investigated. The effect on physico-chemical properties different concentrations (1 and 2% w/v) as well reaction times (2, 4, or 8 h) studied. It was evidenced a...
Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs. One commonly polymer is polyethylene glycol (PEG), owing to its biocompatibility, water solubility, capacity prolong residence time. However, concerns arisen regarding PEG's immunogenicity limited biodegradability. addition, inherent limitations,...
Chitosan is very effective in removing metal ions through their adsorption. A preliminary investigation of the adsorption chromium(III) by chitosan was carried out means batch tests as a function contact time, pH, ion competition, and initial concentration. The rate rather rapid (t1/2 < 18 min) influenced presence other ions. obtained data were tested using Langmuir Freundlich isotherm models and, based on R2 values, former appeared better applicable than latter. found to have an...
Sustainably derived poly(glycerol adipate) (PGA) has been deemed to deliver all the desirable features expected in a polymeric scaffold for drug-delivery, including biodegradability, biocompatibility, self-assembly into nanoparticles (NPs) and functionalisable pendant group. Despite showing these advantages over commercial alkyl polyesters, PGA suffers from series of key drawbacks caused by poor amphiphilic balance. This leads weak drug-polymer interactions subsequent low drug-loading NPs,...
Despite advances in material sciences and clinical procedures for surgical hygiene, medical device implantation still exposes patients to the risk of developing local or systemic infections. The development efficacious antimicrobial/antifouling materials may help with addressing such an issue. In this framework, polyethylene glycol (PEG)-grafted segmented polyurethanes were synthesized, physico-chemically characterized, evaluated respect their bacterial fouling-resistance properties. PEG...
Wound healing is a dynamic process that can be seriously delayed by many factors including infectious complications. The development of dressings with intrinsic wound activity and/or releasing bioactive compounds may help addressing such an issue. In this study, hyaluronic acid (HA) at different percentages (1–35%) was used to modify chitosan (CS) biological and physico-chemical properties in order obtain 2D-matrices able promote protect from infection. HA incorporation the CS matrix...
Solid-phase extraction (SPE) coupled to LC/MS/MS analysis is a valid approach for the determination of organic micropollutants (OMPs) in liquid samples. To remove greatest number OMPs from environmental matrices, development innovative sorbent materials crucial. Recently, much attention has been paid inorganic nanosystems such as graphite-derived materials. Graphene oxide employed water-purification processes, including removal several dyes, flame retardants, or pharmaceutical products....
The replacement and regeneration of biological tissues by fabricating three-dimensional functionalized constructs that can improve material interaction with cells is an important challenge tissue engineering. In this study, bioactive biomimetic scaffolds based on chitosan-alginate polyelectrolyte complexes (PECs) were fabricated freeze-drying method then crosslinked CaCl2. Various (CS-AL) molar ratios used to obtain PECs different structural mechanical properties. CS1-AL2.3 scaffold showed...
Cigarette butts, one of the most common forms litter in world, represent a source chemical and plastic pollution releasing thousands toxic compounds microfibers cellulose acetate (CA). Besides correct waste management, recovery CA from cigarette filters is way to cushion their negative effects on environment. Thus far, recycling strategies have been limited industrial applications, while not many solutions designed for water remediation. This work describes strategy valorize this harmful...
ABSTRACT Indwelling prostheses and subcutaneous delivery devices are now routinely indispensably employed in medical practice. However, these same often provide a highly suitable surface for bacterial adhesion colonization, resulting the formation of complex, differentiated, structured communities known as biofilms. The University Washington Engineered Biomaterials group has developed novel drug polymer matrix consisting poly(2-hydroxyethyl methacrylate) hydrogel coated with ordered...
Usnic acid, a potent antimicrobial and anticancer agent, poorly soluble in water, was complexed to novel polyacrylamides by establishment of strong acidic-base interactions. Thermal spectroscopic analysis evidenced molecular dispersion the drug polymers complete drug/polymer miscibility for all tested compositions. The polymer/drug complexes promptly dissolved water possessed greater activity against Staphylococcus epidermidis than both free polymer alone. best results were obtained with...