A5046909312- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Pesticide Residue Analysis and Safety
- Cancer, Hypoxia, and Metabolism
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Enzyme Structure and Function
- Chemistry and Chemical Engineering
- Mass Spectrometry Techniques and Applications
- Biochemical and Molecular Research
- Microbial Natural Products and Biosynthesis
- Retinoids in leukemia and cellular processes
- Antimicrobial Peptides and Activities
- Amino Acid Enzymes and Metabolism
- Electrochemical sensors and biosensors
- Chemical Synthesis and Analysis
- Metabolism and Genetic Disorders
- Neuropeptides and Animal Physiology
- Natural Compound Pharmacology Studies
- Management, Economics, and Public Policy
- Advanced Cellulose Research Studies
- Advanced Chemical Sensor Technologies
- Pharmaceutical and Antibiotic Environmental Impacts
- Radiomics and Machine Learning in Medical Imaging
- Microplastics and Plastic Pollution
Sapienza University of Rome
2022-2025
Institute of Molecular Biology and Pathology
2023-2024
National Research Council
2023
University of Rome Tor Vergata
2021
Cigarette butts, one of the most common forms litter in world, represent a source chemical and plastic pollution releasing thousands toxic compounds microfibers cellulose acetate (CA). Besides correct waste management, recovery CA from cigarette filters is way to cushion their negative effects on environment. Thus far, recycling strategies have been limited industrial applications, while not many solutions designed for water remediation. This work describes strategy valorize this harmful...
Trypanothione reductase (TR) is a suitable target for drug discovery approaches against leishmaniasis, although the identification of potent inhibitors still challenging. Herein, we harnessed fragment-based (FBDD) strategy to develop new TR inhibitors. Previous crystallographic screening identified fragments
Abstract Nanocomposite microbeads (average diameter = 10–100 µm) were prepared by a microemulsion-solidification method and applied to the magnetic solid-phase extraction (m-SPE) of fourteen analytes, among pesticides, drugs, hormones, from human urine samples. The microbeads, perfectly spherical in shape maximize surface contact with composed nanoparticles dispersed polylactic acid (PLA) solid bulk, decorated multi-walled carbon nanotubes (mPLA@MWCNTs). In particular, PLA was recovered...
Crystallographic fragment screening is a powerful methodology that enables the identification of low molecular weight ligands and has shown great promises in drug discovery. In this work we report results carried out an effort to further map cavities trypanothione reductase from Trypanosoma brucei ( Tb TR), critical target for design against human African trypanosomiases (HAT), which efficient non-toxic trypanocidal drugs are lacking. Moreover, conservation among trypanosomatids, including...
The ability of microplastics (MPs) to retain organic and inorganic pollutants on their surface is widely demonstrated, acting as vectors for these hazardous species, preconcentrating carrying them long distances, particularly in the aquatic environments. For this reason, MPs sorption studies are crucial understand mechanisms involved contaminant retention. In research, behaviour cortisone polypropylene, polystyrene high-density polyethylene Milli-Q water artificial seawater was studied....
Abstract Adequate levels of pyridoxal 5′‐phosphate (PLP), the catalytically active form vitamin B 6 , and its proper distribution in body are essential for human health. The PLP recycling pathway plays a crucial role these processes defects cause severe neurological diseases. enzyme pyridox(am)ine oxidase (PNPO), whose catalytic action yields PLP, is one key players this pathway. Mutations gene encoding PNPO responsible neonatal epilepsy. Recently, has also been described as potential target...
Background: As a result of the paucity treatment, Leishmaniasis continues to provoke about 60,000 deaths every year worldwide. New molecules are needed, and drug discovery research is oriented toward targeting proteins crucial for parasite survival. Among them, trypanothione reductase (TR) remarkable interest owing its vital role in Leishmania species protozoan life. Our previously identified compound 1 novel chemotype endowed with unique mode TR inhibition thanks binding formerly unknown...
This paper illustrates an enrichment procedure based on the combination of solid phase extraction (SPE) with dispersive liquid-liquid microextraction (DLLME) for determination ng/L concentration levels glucocorticoids in river water samples. In SPE-DLLME, target analytes were adsorbed by loading a large volume sample (200 mL) into OASIS HLB cartridge (60 mg). After their desorption small ethyl acetate (500 µL), this eluate was used as dispersant following DLLME, performed 5 mL water, using...
The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in a variety of central nervous system disorders and whose agonists have neuroprotective activity. In spite σ1-R's physio-pathological pharmacological importance, two the most important features required to fully understand σ1-R function, namely endogenous ligand(s) molecular mechanism ligand access binding site, not yet been unequivocally determined. this work, we performed dynamics (MD)...
In this study, the attention was focused on quizalofop-ethyl, a chiral herbicide whose formulation has recently been marketed as quizalofop-P-ethyl, i.e. (+)-enantiomer exhibiting herbicidal activity. To verify real enantiomeric purity of product well to study its environmental fate, enantioselective separation P- and M- enantiomers quizalofop-ethyl achieved Lux Cellulose-2 column (3‑chloro,4-methylphenilcarbamate cellulose) under isocratic conditions in polar organic mode. Once established...
Synthetic therapeutic peptides (STP) are intensively studied as new‐generation drugs, characterized by high purity, biocompatibility, selectivity and stereochemical control. However, most of the studies focussed on bioactivity STP without considering how formulation actually used for therapy administration could alter physico‐chemical properties active principle. The aggregation a 20‐mer (Ac‐His‐Ala‐Arg‐Ile‐Lys‐D‐Pro‐Thr‐Phe‐Arg‐Arg‐D‐Leu‐Lys‐Trp‐Lys‐Tyr‐Lys‐Gly‐Lys‐Phe‐Trp‐NH 2 ), showing...
Pyridoxal 5′‐phosphate (PLP), the catalytically active form of vitamin B 6 , acts as a cofactor in many metabolic processes. In humans, PLP is produced reactions catalysed by pyridox(am)ine oxidase (PNPO) and pyridoxal kinase (PDXK). Both PNPO PDXK are involved cancer progression tumours. The silencing encoding genes determines strong reduction tumour size neoplastic cell invasiveness models acute myeloid leukaemia (in case PDXK) ovarian breast PNPO). present work, we demonstrate that...