A5084861007- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Carbon dioxide utilization in catalysis
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Polymer Foaming and Composites
- Synthetic Organic Chemistry Methods
- Electrospun Nanofibers in Biomedical Applications
- Catalysis and Oxidation Reactions
University of Nottingham
2022-2024
Sustainably derived poly(glycerol adipate) (PGA) has been deemed to deliver all the desirable features expected in a polymeric scaffold for drug-delivery, including biodegradability, biocompatibility, self-assembly into nanoparticles (NPs) and functionalisable pendant group. Despite showing these advantages over commercial alkyl polyesters, PGA suffers from series of key drawbacks caused by poor amphiphilic balance. This leads weak drug-polymer interactions subsequent low drug-loading NPs,...
Despite the success of polyethylene glycol-based (PEGylated) polyesters in drug delivery and biomedical fields, concerns have arisen regarding PEG's immunogenicity limited biodegradability. In addition, inherent limitations, including chemical handles as well highly hydrophobic nature, can restrict their effectiveness physiological conditions polyester counterpart. To address these matters, an increasing amount research has been focused towards identifying alternatives to PEG. One promising...
Radical ring opening polymerisation (RROP) of cyclic ketene acetals (CKAs) is an attractive technique to synthesize branched, (bio)degradable polyesters. However, CKAs as monomers RROP suffer from hydrolysis lability, making aqueous heterogeneous precipitation polymerisations challenging. In order explore the 2-methylene-1,3,6-trioxocane (MTC) and avoid monomer, kinetic studies in supercritical CO2 (scCO2) were performed. Tuning reaction pressure temperature allowed for synthesis varying...
A new, robust methodology for the synthesis of polystyrene-poly(methyl methacrylate) (PS-PMMA) core-shell particles using seeded dispersion polymerisation in supercritical carbon dioxide is reported, where ratio can be controlled predictably via manipulation reagent stoichiometry. The key development application an iterative addition MMA shell monomer to pre-prepared PS core. Analysis materials with differing ratios indicates that all are isolated as single particle populations distinct and...