We describe herein an organocatalytic enantioselective approach for the construction of axially chiral sulfone-containing styrenes. Various styrene compounds were prepared with excellent enantioselectivities (up to >99% ee) and almost complete E/Z selectivities (>99% E/Z). Furthermore, styrenes could be easily converted into phosphonic acid S/P ligands, which potentially used as organocatalysts or ligands in asymmetric catalysis.

A freestanding mesoporous CuCo₂O₄ nanograss electrode exhibits a superior pseudocapacitive performance and high electrocatalytic activity towards methanol oxidation.

The rational design and fabrication of promising electrodes with prominent energy storage property conversion performance is crucial for supercapacitors electrocatalysis. Herein, potato chip-like cobalt nickel-layered double hydroxide@polypyrrole-cotton pad (CoNi-LDH@PCPs) composite was synthesized by in situ polymerization, which coupled facile solution reaction ion-exchange etching process. An interesting structure can effectively expedite the kinetics electrode reactions, while...

A highly diastereo- and enantioselective methodology for the asymmetric synthesis of vicinal diaxial styrenes multiaxis system was achieved by organocatalysis. Various systems were obtained in excellent manners. The mechanism studies revealed that a new tetra-substituted vinylidene ortho-quinone methide (VQM) intermediate likely involved accounted enantioselectivity.

A chiral Brønsted base catalyzed asymmetric annulation of ortho-alkynylanilines has been developed to access axially naphthyl-C2-indoles via vinylidene ortho-quinone methide (VQM) intermediates. This strategy provides a unique organocatalytic atroposelective route aryl-C2-indole skeletons with excellent enantioselectivity and functional-group tolerance. transformation was applicable decagram-scale preparation (50.0 g) perfect through simple recrystallization. Moreover, the utility this...

ConspectusAtropisomers, arising from conformational restriction, are inherently chiral due to the intersecting dissymmetric planes. Since there numerous applications of enantiopure atropisomers in catalyst design, drug discovery, and material science, asymmetric preparation these highly prized molecules has become a flourishing field synthetic chemistry. A number catalysts, procedures, novel concepts have been developed for manufacture atropisomeric molecules. However, intrinsic properties...

Advanced techniques for both environmental and biological prescription drug monitoring are of ongoing interest. In this work, a fluorescent sensor based on an Eu3+-doped anionic zinc-based metal–organic framework (Eu3+@Zn-MOF) was constructed rapid visual analysis the molecule demecycline (DEM), achieving high sensitivity selectivity. The ligand 2-amino-[1,1′-biphenyl]-4,4′-dicarboxylic acid (bpdc-NH2) not only provides stable cyan fluorescence (467 nm) through intramolecular charge transfer...

Well-aligned nickel oxide (NiO) nanosheets with the thickness of a few nanometers supported on flexible substrate (Ni foam) have been fabricated by hydrothermal approach together post-annealing treatment. The three-dimensional NiO were further used as electrode materials to fabricate supercapacitors, high specific capacitance 943.5, 791.2, 613.5, 480, and 457.5 F g(-1) at current densities 5, 10, 15, 20, 25 A g(-1), respectively. combined well substrate. When material was bended, it can...

We report the synthesis of three dimensional (3D) NiCo2O4@NiCo2O4 nanocactus arrays grown directly on a Ni current collector using facile solution method followed by electrodeposition. They possess unique 3D hierarchical core-shell structure with large surface area and dual-functionalities that can serve as electrodes for both supercapacitors (SCs) lithium-ion batteries (LIBs). As SC electrode, they deliver remarkable specific capacitance 1264 F g(-1) at density 2 A ~93.4% retention after...

Abstract The enantioselective construction of axially chiral aryl‐naphthopyran skeletons was realized by organocatalytic atroposelective intramolecular [4+2] cycloaddition in situ generated vinylidene ortho ‐quinone methides, from 2‐ethynylphenol derivatives, with alkynes. Through this method, the heteroatropisomers were obtained excellent yields and enantioselectivities. Moreover, a speculative model stereochemical outcome is proposed based on preliminary mechanistic studies. products...

ZnCo2O4 nanoflakes, as electrodes for supercapacitors, are grown on a cellular nickel foam using cost-effective hydrothermal procedure. The mesoporous nanoflakes have large electroactive surface areas with strong adhesion to the Ni foam, allowing fast ion and electron transport. nanoarchitecture deliver an excellent specific capacitance of 1220 F g(-1) at current density 2 A in M KOH aqueous solution long-term cyclic stability 94.2% retention after 5000 cycles. fabrication strategy is...

Abstract A highly diastereo‐ and enantio‐selective method for the asymmetric synthesis of molecules containing helicenes stereogenic axes was developed based on organocatalysis. Various compounds bearing both helical axial elements were obtained in excellent enantioselectivities. The mechanism study revealed that reaction proceeded through two stages: 1) first cyclization produces a intermediate axis. 2) dynamic kinetic resolution helix following with generates another

We report the growth of high-quality CdS/CdSxSe1–x axial heterostructure nanowires (NWHs) via a temperature-controlled chemical vapor deposition method. Microstructural characterizations revealed that these NWHs have single-crystalline structure with abrupt heterojunctions. Local photoluminescence and mapping near heterojunctions show only two separated narrow band-edge emission bands from different adjacent semiconductors, further demonstrating heterostructures. Moreover, photodetector...

Novel graphene-like CuO nanofilms are grown on a copper foam substrate by in situ anodization for multifunctional applications as supercapacitor electrodes and photocatalysts the degradation of dye pollutants. The as-prepared consists interconnected, highly crystalline, conductive nanosheets with hierarchical open mesopores large surface area. supported employed freestanding, binder-free supercapacitors, which exhibit wonderful electrochemical performance specific capacitance (919 F g(-1) at...

Abstract Carbon nanotubes (CNTs) incorporated porous 3-dimensional (3D) CuS microspheres have been successfully synthesized via a simple refluxing method assisted by PVP. The composites are composed of flower-shaped secondary microspheres, which in turn assembled with primary nanosheets 15–30 nm thickness and fully integrated CNT. possess large specific surface area 189.6 m 2 g −1 high conductivity 0.471 S cm . As electrode materials for supercapacitors, the nanocomposites show excellent...

An organocatalytic enantioselective method for the synthesis of multiple stereoisomers bearing E, Z configurations, stereogenic carbon centers, and axially chiral styrenes is reported. The enabled rapid construction a series stereochemical complexity products with excellent selectivity, diastereoselectivity (>20:1 dr), enantioselectivity (up to 96% ee). This provides an efficient concise route wide range potential applications in organic synthesis.

Abstract Described herein is the enantioselective construction of oxygen‐containing [5‐6‐5] tricyclic heterocycles by an organocatalyzed asymmetric [4+2] cycloaddition vinylidene ortho ‐quinone methides and benzofurans. According to this methodology, a series with various functional groups were synthesized in excellent enantio‐ diastereoselectivities (>99 % ee , >20:1 d.r.). Furthermore, deuterium‐labeling experiments high‐resolution mass spectroscopy demonstrated that methide...

Abstract Enantioselective construction of molecules bearing multiple stereogenic elements is increasingly related to the synthesis enantiopure natural products, pharmaceuticals, and functional materials. However, atom‐economical enantioselective approaches install in a small molecular template by limited chemical transformation remain challenging. We describe an organocatalytic method for preparation polychiral four types fused azepines via vinylidene ortho ‐quinone methide ( VQM )‐mediated...

Open AccessCCS ChemistryRESEARCH ARTICLE5 Aug 2022Diversity-Oriented Enantioselective Construction of Atropisomeric Heterobiaryls and N-Aryl Indoles via Vinylidene Ortho-Quinone Methides Da Xu†, Shengli Huang†, Fangli Hu, Lei Peng, Shiqi Jia, Hui Mao, Xiangnan Gong, Fenglan Li, Wenling Qin Hailong Yan Xu† Chongqing Key Laboratory Natural Product Synthesis Drug Research, School Pharmaceutical Sciences, University, 401331 †D. Xu S. Huang contributed equally to this work.Google Scholar More...

Abstract We herein demonstrated an efficient method for the atroposelective construction of nine‐membered carbonate‐bridged biaryls through vinylidene ortho ‐quinone methide (VQM) intermediates. Diverse products with desirable pharmacological features were synthesized in satisfying yields and good to excellent enantioselectivities. In subsequent bioassays, several agents showed considerable antiproliferative activity via mitochondrial‐related apoptosis mechanism. Further transformations...

Nonactivated arenes, such as benzene derivatives, are chemically inert due to their intrinsic aromaticity and low polarity. The catalytic asymmetric dearomatization (CADA, coined by You co-workers) of the nonactivated arenes represents a formidable challenge. We herein demonstrated an organocatalytic dearomatizing hetero-Diels–Alder reaction derivatives. tunable regioselectivity this strategy allowed delivery diversity stereochemically complex polycyclic compounds oxahelicenes with excellent...

Abstract 1,2-Azoles are privileged structures in ligand/catalyst design and widely exist many important natural products drugs. In this report, two types of axially chiral 1,2-azoles (naphthyl-isothiazole S-oxides with a stereogenic sulfur center atropoisomeric naphthyl pyrazoles) synthesized via modified vinylidene ortho -quinone methide intermediates. Diverse acquired satisfying yields good to excellent enantioselectivities. The intermediates bearing hetero atoms at 5-position have been...

The industrialization and commercialization of Li-S batteries are greatly hindered by several defects such as the sluggish reaction kinetics, polysulfide shuttling large volume expansion. Herein, we propose a heteroatom doping method to optimize electronic structure for enhancing adsorption catalytic activity VN that is in situ embedded into spongy N-doped conductive framework, thus obtaining Co-VN/NC multifunctional catalyst an ideal sulfur host. synthesized composite has both unique...