A5044047007- Catalytic C–H Functionalization Methods
- Synthesis of Indole Derivatives
- Axial and Atropisomeric Chirality Synthesis
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Polysaccharides Composition and Applications
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Proteins in Food Systems
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Metabolomics and Mass Spectrometry Studies
- Cyclopropane Reaction Mechanisms
- Neurobiology and Insect Physiology Research
- Multilevel Inverters and Converters
- Inorganic Fluorides and Related Compounds
- Radical Photochemical Reactions
- Traditional Chinese Medicine Analysis
- Polysaccharides and Plant Cell Walls
- Advanced Proteomics Techniques and Applications
- Ziziphus Jujuba Studies and Applications
- Ion channel regulation and function
Zhejiang University
2018-2023
Quanzhou Normal University
2023
Shanghai Institute of Organic Chemistry
2021
Hangzhou Xixi hospital
2019-2021
State Council of the People's Republic of China
2019-2021
Chinese Academy of Sciences
2021
Chongqing University
2015-2018
Nantong University
2014
Nantong Tumor Hospital
2014
Nanjing University
2011
Abstract The enantioselective construction of axially chiral aryl‐naphthopyran skeletons was realized by organocatalytic atroposelective intramolecular [4+2] cycloaddition in situ generated vinylidene ortho ‐quinone methides, from 2‐ethynylphenol derivatives, with alkynes. Through this method, the heteroatropisomers were obtained excellent yields and enantioselectivities. Moreover, a speculative model stereochemical outcome is proposed based on preliminary mechanistic studies. products...
Abstract Described herein is the enantioselective construction of oxygen‐containing [5‐6‐5] tricyclic heterocycles by an organocatalyzed asymmetric [4+2] cycloaddition vinylidene ortho ‐quinone methides and benzofurans. According to this methodology, a series with various functional groups were synthesized in excellent enantio‐ diastereoselectivities (>99 % ee , >20:1 d.r.). Furthermore, deuterium‐labeling experiments high‐resolution mass spectroscopy demonstrated that methide...
Rhodium-catalyzed green synthesis of isoindolin-1-ones via a sequential C-H activation/allene formation/cyclization pathway by applying water as solvent is reported. The reaction highly regioselective, tolerating some potentially useful functional groups.
Abstract Reported herein is the first enantioselective β‐elimination reaction catalyzed by a chiral cation‐binding polyether. By using this catalytic protocol, wide range of β‐sulfonyl ketones could be effectively resolved with high stereoselectivity ( S up to >300). Key success process favorable secondary interactions catalyst Lewis basic groups on sulfone substrate. The enone product can easily converted into racemic starting material, and allows an effective recycling overall synthesis...
Abstract The enantioselective construction of axially chiral aryl‐naphthopyran skeletons was realized by organocatalytic atroposelective intramolecular [4+2] cycloaddition in situ generated vinylidene ortho ‐quinone methides, from 2‐ethynylphenol derivatives, with alkynes. Through this method, the heteroatropisomers were obtained excellent yields and enantioselectivities. Moreover, a speculative model stereochemical outcome is proposed based on preliminary mechanistic studies. products...
A copper-catalyzed 1,4-addition reaction of sulfonyl iodides with 1,3-enynes affording various allenyl halides in high yields under mild conditions has been developed. Mechanistic studies showed that the proceeds through a radical mechanism.
An efficient Ru-catalyzed approach to tetrasubstituted allenes from benzoic acids and propargylic acetates has been developed.
Abstract Described herein is the enantioselective construction of oxygen‐containing [5‐6‐5] tricyclic heterocycles by an organocatalyzed asymmetric [4+2] cycloaddition vinylidene ortho ‐quinone methides and benzofurans. According to this methodology, a series with various functional groups were synthesized in excellent enantio‐ diastereoselectivities (>99 % ee , >20:1 d.r.). Furthermore, deuterium‐labeling experiments high‐resolution mass spectroscopy demonstrated that methide...
Abstract In this study, the concept of cooperative cation‐binding catalysis was applied for direct generation two contiguous trisubstituted and tetrasubstituted stereogenic centers. Using readily accessible chiral oligoethylene glycol (oligoEG) as a catalyst, asymmetric Mannich reactions α‐thiocyanato cyclic ketones donors were performed with α‐amidosulfones bench‐stable imine precursors in presence potassium fluoride base, affording 2‐thiocyanato‐2‐(1‐aminoalkyl)‐substituted 1‐tetralones...
Abstract Reported herein is the first enantioselective β‐elimination reaction catalyzed by a chiral cation‐binding polyether. By using this catalytic protocol, wide range of β‐sulfonyl ketones could be effectively resolved with high stereoselectivity ( S up to >300). Key success process favorable secondary interactions catalyst Lewis basic groups on sulfone substrate. The enone product can easily converted into racemic starting material, and allows an effective recycling overall synthesis...
An unexpected rhodium-catalyzed highly regio- and stereo-selective bimolecular nucleophilic oxyrhodation/insertion/1,4-Rh migration/β-H elimination reaction of 2,3-allenols affording (2,5-dihydrofuran-3-yl)but-2(<italic>E</italic>)-en-1-one derivatives is reported.
Allenenitriles bearing different synthetically versatile functional groups have been prepared smoothly from 5-alkynyl fluorosulfonamides in decent yields with an excellent chemo- and regio-selectivity under redox neutral conditions. The resulting allenenitriles can be readily converted to useful functionalized heterocycles. Based on mechanistic study, it is confirmed that this the first example of radical-based non-activated propargylic C-H functionalization for allene syntheses.
This paper designs an LLC converter with super-wide output voltage. A variable-mode control strategy three operating modes is adopted for the converter, and a novel optimal parameters design method based on this proposed. The designed can achieve voltage range at various load without increasing circuit's complexity, expanding frequency phase-shifted range. magnetizing inductance maximized to decrease conduction losses condition that requirements of wide gain primary MOSFETs' soft-switching...
Herein we report a [Cp*RhCl 2 ] -catalyzed coupling cyclization of two different classes allenes with 2,3-allenoic acids affording 2(5 H )-furanone skeletons products and 2,3-allenols forming conjugated ( E )-enal or enone functionality to the β-position )-furanones.
A K2S2O8-activated regioselective alkylation of α-amido sulfones at the C-3 position indoles is reported. The protocol developed herein provides an alternative new strategy to previous approach by using Lewis acid, clay, and resin as catalyst for this Friedel–Crafts type with sulfones. formed product bears a versatile transformable sulfone group amino group. reaction condition tolerant wide range substrates, including series electron-withdrawing electron-donating groups different positions....
Abstract In the presence of KF as reagent and a chiral BINOL‐derived cation‐binding polyether catalyst, first asymmetric β‐elimination sulfones type (I) (III) is achieved resulting in kinetic resolution to give corresponding (R)‐sulfones with e.e.′s better than 90%.