A5057234329- Heat shock proteins research
- Thermal Regulation in Medicine
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Sepsis Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Bee Products Chemical Analysis
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Glycation End Products research
- Intensive Care Unit Cognitive Disorders
- Gout, Hyperuricemia, Uric Acid
- Adrenal Hormones and Disorders
- Clinical Nutrition and Gastroenterology
- Fatty Acid Research and Health
- Acupuncture Treatment Research Studies
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Cardiovascular Disease and Adiposity
- Traditional Chinese Medicine Studies
- Hematological disorders and diagnostics
- Healthcare and Venom Research
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Respiratory Support and Mechanisms
- Infectious Diseases and Tuberculosis
Guangzhou University of Chinese Medicine
2015-2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2018-2025
Southern Medical University
2020
Abstract Cell apoptosis induced by heat stress is regulated a complex signaling network. We previously reported that p53-dependent pathway involved. Here, we present evidence NF-κB plays crucial role in preventing stress-induced early apoptosis. Human umbilical vein endothelial cells (HUVECs) were examined and increased phosphorylation of p65 IκBα detected, without degradation. When was inhibited BAY11-7082, or small interference RNA (siRNA) targeting , significant increase cell caspase-3...
The pathogenesis of heatstroke is a multi-factorial process involved with an interplay among subsequent inflammation, endothelial injury and coagulation disturbances, which makes pharmacological therapy challenging problem. Xuebijing injection (XBJ), traditional Chinese medicine used to sepsis, has been reported suppress inflammatory responses restore disturbances. However, little known about the role XBJ in heatstroke. Mice were treated indicated dose before and/or after induction Serum...
Increased vascular permeability leading to acute lung injury (ALI) and respiratory distress syndrome (ARDS) is central the pathogenesis of heatstroke. Protease-activated receptor 1 (PAR1), for thrombin, plays a key role in disruption endothelial barrier function response extracellular stimuli. However, PAR1 heat stress-induced hyper-permeability unknown. In this study, we measured protein expression heat-stressed human umbilical venous cells (HUVECs), investigated influences on permeability,...
Background . Acupuncture at Zusanli (ST36), Quchi (LI11), and Tianshu (ST25) is commonly used in septic patients by traditional Chinese physicians. The protective effect of acupuncture ST36 on the intestinal barrier associated with Cholinergic Anti‐Inflammatory Pathway (CAIP). However, its detailed mechanism whether LI11 ST25 have similar effects to remain unclear. Aim To explore electroacupuncture (EA) ST36, LI11, rats investigate role spleen treatment EA ST36. Methods A rat model caused...
Sini Decoction (SND) is composed of Aconitum carmichaelii Debeaux, Zingiber officinale Roscoe, and Glycyrrhiza uralensis Fisch, having been used in China for centuries collapsing phrase disease. Studies reported that SND could alleviate inflammatory response, ameliorate microcirculatory disturbances, improve shock reversal adrenal gland glucocorticoid stress response during sepsis shock, yet the underlying mechanism still elusive. Toll-like receptor (TLR) 4 demonstrated to be crucially...
To study the role of receptor for advanced glycation end products (RAGE) in endothelial barrier dysfunction induced by heat stress, to further explore signal pathway which RAGE contributes heat-induced endothelia response, and thereby find a novel target clinical treatment ALI (acute lung injury) heatstroke. This established animal model heatstroke using knockout mice. We observed acute injury mice evaluating leukocytes, neutrophils, protein concentration BALF (Bronchoalveolar lavage...
Immunologic derangement may be the critical pathophysiologic mechanism in sepsis, and immunotherapy might a potential new treatment. Si-ni-tang (SNT), an ancient Chinese herbal formula documented Shanghan Lun, has been used for treating severe sepsis thousands of years. Research shows that it have therapeutic benefit sepsis. This study will evaluate feasibility testing effects SNT on immune function patients.This is pilot randomized controlled study. Eligible patients admitted to our medical...
Abstract Rational: Thrombolysis in primigravida with hemodynamic instability is controversial, especially treatment low-dosage recombinant tissue plasminogen activator (rtPA), and related studies are extremely rare. Here, we report the case of a 26-year-old diagnosed an acute massive pulmonary embolism (PE) that prompted initiation thrombolysis low-dose alteplase. Patient concerns: The patient was admitted to Emergency Department chief complaints sudden onset dyspnea, chest tightness,...