A5007405110- Iron Metabolism and Disorders
- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Hemoglobinopathies and Related Disorders
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Occupational exposure and asthma
- Hydrogen's biological and therapeutic effects
- Air Quality and Health Impacts
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Seaweed-derived Bioactive Compounds
- Erythropoietin and Anemia Treatment
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Oral Health Pathology and Treatment
- Redox biology and oxidative stress
- Probiotics and Fermented Foods
- Cell Adhesion Molecules Research
- Contact Dermatitis and Allergies
- Biomarkers in Disease Mechanisms
- Metabolism and Genetic Disorders
Brown University
2018-2025
John Brown University
2023-2025
St. John's University
2016
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically results from inhalational exposures individuals who work industrial settings. The first known disease of inherited Mn excess, identified 2012, caused by mutations the exporter SLC30A10 characterized dystonia, cirrhosis, polycythemia. To investigate role homeostasis, we generated whole-body Slc30a10–deficient mice, which developed severe excess impaired systemic biliary excretion. Slc30a10 localized to...
The manganese (Mn) export protein SLC30A10 is essential for Mn excretion via the liver and intestines. Patients with deficiency develop excess, dystonia, disease, polycythemia. Recent genome-wide association studies revealed a link between variant T95I markers of disease. in vivo relevance this has yet to be investigated. Using vitro models, we explore impact on function. While I95 expressed at lower levels than T95 transfected cell lines, both variants protected cells similarly from...
Abstract Manganese (Mn) is an essential trace element required for various biological functions, but excessive Mn levels are neurotoxic and lead to significant health concerns. The mechanisms underlying Mn-induced neurotoxicity remain poorly understood. Neuropathological studies of affected brain regions reveal astrogliosis, neuronal loss, along with evidence neuroinflammation. Here, we present a novel Mn-dependent mechanism linking mitochondrial dysfunction We found that disrupts...
Extensive industrial and military uses of tungsten have raised the possibilities human occupational environmental exposure to nanoparticles this metal, with concomitant health concerns. The goal study was investigate potential mechanism pulmonary toxicity associated inhaled (IV) oxide (WO3 NPs) in Golden Syrian Hamsters. Animals exposed WO3 NPs via inhalation were divided into three groups - control two treatment either 5 or 10 mg/m3 aerosolized for 4 h/day four days. A long-term (4 eight...
Iron is essential for erythropoiesis and other biological processes, but toxic in excess. Dietary absorption of iron a highly regulated process major determinant body levels. excretion, however, considered passive, unregulated process, the underlying pathways are unknown. Here we investigated role metal transporters SLC39A14 SLC30A10 biliary excretion. While imports manganese into liver organs under physiological conditions, it conditions exports from hepatocytes bile. We hypothesized that...
Manganese is an essential yet potentially toxic metal. Initially reported in 2012, mutations SLC30A10 are the first known inherited cause of manganese excess. apical membrane protein that exports from hepatocytes into bile and enterocytes lumen gastrointestinal tract. deficiency results impaired excretion, leading to excess, neurologic deficits, liver cirrhosis, polycythemia, erythropoietin Neurologic disease attributed toxicity. Polycythemia The goal this study was determine basis excess...
The current paradigm in the field of mammalian iron biology states that body levels are determined by dietary absorption, not excretion. Iron absorption is a highly regulated process influenced and other factors. excretion believed to occur at basal rate irrespective associated with processes such as turnover intestinal epithelium, blood loss, exfoliation dead skin. Here we explore mouse model excess due inherited transferrin deficiency. this attributed impaired regulation leading excessive...
Manganese is an essential yet potentially toxic metal. Initially reported in 2012, mutations SLC30A10 are the first known inherited cause of manganese excess. apical membrane transport protein that exports from hepatocytes into bile and enterocytes lumen gastrointestinal tract. deficiency results impaired excretion, leading to severe excess, neurologic deficits, liver cirrhosis, polycythemia, erythropoietin Neurologic disease attributed toxicity. Polycythemia but basis excess has be...
Croton oil is liquid at room temperature, with a pale-yellow color and spicy odor. It commonly used in combination phenol as chemical peeling agent dermatology, which reveals its caustic exfoliating effects. Topical use of croton high dose produces skin irritation, inflammation, swelling, pain, even tumors. Therefore, has been widely for tumor related research, different animal models having established. However, mechanistic studies through induces injury activates tissue repair/regeneration...
Abstract SLC30A10 deficiency is a disease of severe manganese excess attributed to loss SLC30A10-dependent excretion via the gastrointestinal tract. Patients develop dystonia, cirrhosis, and polycythemia. They are treated with chelators but also respond oral iron, suggesting that iron can outcompete for absorption in this disease. Here we explore latter observation. Intriguingly, increased Slc30a10-deficient mice despite excess. Studies multiple mouse models indicate dietary reflects two...
Abstract Iron is an essential nutrient but toxic in excess. deficiency the most prevalent nutritional and typically linked to inadequate intake. excess also common usually due genetic defects that perturb expression of hepcidin, a hormone inhibits dietary iron absorption. Our understanding absorption far exceeds excretion, which believed contribute minimally homeostasis. Prior discovery multiple studies showed undergoes biliary excretion. We recently reported wild-type mice raised on...