A5059444918- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Myofascial pain diagnosis and treatment
- Pain Management and Placebo Effect
- Inflammatory mediators and NSAID effects
- Pain Management and Opioid Use
- Neuropeptides and Animal Physiology
- Spine and Intervertebral Disc Pathology
- Sports injuries and prevention
- Urticaria and Related Conditions
- Inflammatory Myopathies and Dermatomyositis
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Sclerosis and Related Diseases
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Pain Management and Treatment
- Rheumatoid Arthritis Research and Therapies
- Eicosanoids and Hypertension Pharmacology
- Religion, Spirituality, and Psychology
- Spondyloarthritis Studies and Treatments
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Diabetes Management and Education
- Biomedical and Chemical Research
University of Zurich
2013-2024
Zentrum für Gefässkrankheiten
2015-2024
Schulthess-Klinik
2018
University Hospital of Zurich
2004-2013
Swiss Integrative Center for Human Health
2005-2012
Pfizer (United Kingdom)
2007
Mundipharma (United Kingdom)
2007
Janssen (Italy)
2007
Friedrich Schiller University Jena
1992-2001
German Society of Surgery
1998
Abstract Objective To examine the expression and regulation of interleukin‐21 (IL‐21) IL‐21 receptor (IL‐21R) in patients with systemic sclerosis (SSc; scleroderma). Methods Skin biopsy specimens were obtained from 23 SSc 15 healthy controls. IL‐21/IL‐21R messenger RNA (mRNA) was quantified using real‐time polymerase chain reaction (PCR). The pattern analyzed by situ hybridization Western blotting. Stimulation experiments performed cultured dermal fibroblasts controls as well keratinocytes,...
Abstract The symmetry of, and physical characteristics influencing, the thickness of lateral abdominal muscles at rest during exercises were examined in 57 healthy subjects (20 men, 37 women; aged 22–62 years). M‐mode ultrasound images recorded from hollowing hook‐lying. fascial lines bordering transvs. abdominis, obliquus internus externus digitized absolute thickness, relative (% total thickness) contraction ratio (thickness hollowing/thickness rest), as well asymmetry (difference between...
Catastrophizing plays an important role in models of pain chronicity, showing a consistent correlation with both intensity and disability. It is conceivable that these associations are mediated or confounded by other psychological attributes.To examine the relative influence catastrophizing variables on disability patients chronic low back pain.Seventy-eight completed Pain Scale, Roland Morris Disability Questionnaire, Fear-Avoidance Beliefs Questionnaire (work/activity), Modified Somatic...
Objective. Skin temperature and skin blood flow were studied above different tender points in 20 patients with fibromyalgia (FM) healthy controls.
<b>Objective:</b> To determine whether there is evidence of increased DNA fragmentation and ultrastructural changes in muscle tissue patients with fibromyalgia (FM) compared healthy controls. <b>Methods:</b> Muscle tissues from 10 community residents FM age sex matched controls were examined "blindly" for the presence by two different methods: terminal deoxynucleotidyl transferase (TdT) staining (TUNEL) FragEL-Klenow detection kit. Ultrastructural analysis was performed electron microscopy....
Brain-derived neurotrophic factor (BDNF), a neuromodulator involved in nociceptive hypersensitivity the central nervous system, is also expressed synoviocytes of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. We investigated role P2 purinoreceptors induction BDNF expression synovial fibroblasts (SF) OA RA Cultured SF from patients with symptomatic knee were stimulated purinoreceptor agonists ATP, ADP, or UTP. The mRNA was measured by quantitative TaqMan PCR. release into cell...
Joint pain causes significant morbidity in osteoarthritis (OA). The aetiology of joint OA is not well understood. synovial membrane as an innervated structure represents a potential source peripheral OA. Here we analyse, using hypothesis-free next generation RNA sequencing, the differences protein-coding and non-coding transcriptomes knee tissues from patients with high (n = 5) compared low 5), evaluated by visual analogue scale (VAS). We conduct Gene Ontology pathway analyses on...
Abstract This unblinded preliminary case-control study was done to demonstrate functional and structural changes in the microcirculation of patients with primary fibromyalgia (FM). We studied 10 women (54.0 ± 3.7 years age) FM diagnosed accordance classification criteria American College Rheumatology, controls three groups (n = each group) – age-matched who were healthy or had rheumatoid arthritis systemic scleroderma (SSc). All 40 subjects tested within a 5-week period by same...
Cross-sectional study.Comparison of the timing onset lateral abdominal muscle activity during rapid arm movements in patients with nonspecific chronic low back pain (cLBP) and back-pain-free controls.Rapid are normally associated prior activation trunk-stabilizing muscles readiness for impending postural perturbation. Using invasive intramuscular electromyography techniques, studies have shown that this feed-forward function is delayed some (LBP). Ultrasound tissue Doppler imaging (TDI)...
Abstract Background Fibromyalgia syndrome ( FMS ) is frequently associated with psychiatric conditions, particularly anxiety. Deficits in contingency learning during fear conditioning have been hypothesized to increase anxiety and, consequently, pain sensation susceptible individuals. The goal of this study was examine the relationship between and experience subjects rheumatoid arthritis RA ). Methods Fourteen female subjects, 14 age‐matched healthy controls HCs were included a...
Rapid arm movements elicit anticipatory activation of the deep-lying abdominal muscles; this appears modified in back pain, but invasive technique used for its assessment [fine-wire electromyography (EMG)] has precluded widespread investigation. We examined whether tissue-velocity changes recorded with ultrasound (M-mode) tissue Doppler imaging (TDI) provided a viable noninvasive alternative. Fourteen healthy subjects rapidly flexed, extended, and abducted shoulder; recordings were made...