A5089250311- Research on Leishmaniasis Studies
- Tryptophan and brain disorders
- Treatment of Major Depression
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Functional Brain Connectivity Studies
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- Lymphatic System and Diseases
- Mental Health Research Topics
- Asthma and respiratory diseases
Fundação Oswaldo Cruz
2018-2021
Universidade Federal da Bahia
2017-2018
Complexo Hospitalar Universitário Professor Edgard Santos
2017
Introduction: The use of ketamine as an option in the treatment depressive disorder is growing rapidly, supported by numerous clinical trials attesting its efficacy and safety. Esketamine, S (+) enantiomer ketamine, most widely used form anesthetic environment some countries, new studies have shown that it may also be effective depression with better tolerability. However, no study so far has directly compared esketamine racemic ketamine. Here we propose a protocol trial to evaluate...
Early cutaneous leishmaniasis (ECL) is characterized by a nonulcerated papular lesion and illness duration less than 30 days. Approximately 4 weeks later, the (CL) ulcers appear. We were surprised to find that failure after antimony therapy (Sb5) higher in ECL CL. hypothesize inflammatory response patients may increase during Sb5 therapy, which leads treatment failure. A cohort of 44 infected Leishmania braziliensis was established evaluate compare immunologic responses with CL healthy...
Psoriasis is a chronic, inflammatory disease affecting the skin and joints. The pathogenesis of this associated with genetic, environmental immunological factors, especially unbalanced T cell activation improper keratinocyte differentiation. Psoriatic lesion infiltrate composed monocytes cells, most studies have focused on participation cells in disease. Here we investigated contribution mononuclear phagocytes immunopathology observed psoriatic patients. Significant increases levels TNF,...
Evidence suggests that ketamine's influence on brain-derived neurotrophic factor (BDNF) might be involved in its mechanism of rapid antidepressant action. We aimed to evaluate the differential impact ketamine and esketamine serum BDNF levels association with response patterns treatment-resistant depression (TRD).