A5088951077- Zebrafish Biomedical Research Applications
- Single-cell and spatial transcriptomics
- Retinal Development and Disorders
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced Fluorescence Microscopy Techniques
- Gene Regulatory Network Analysis
Max Planck Institute for Biological Intelligence
2022-2025
Max Planck Institute of Neurobiology
2014-2022
Zebrafish larvae show characteristic prey capture behavior in response to small moving objects. The neural mechanism used recognize objects as remains largely unknown. We devised a machine learning classification system quantify hunting kinematics semi-restrained animals exposed range of virtual stimuli. Two-photon calcium imaging revealed visual area, AF7, that was activated specifically by the optimal stimulus. This pretectal region is innervated two types retinal ganglion cells, which...
The advent of multimodal brain atlases promises to accelerate progress in neuroscience by allowing silico queries neuron morphology, connectivity, and gene expression. We used multiplexed fluorescent situ RNA hybridization chain reaction (HCR) technology generate expression maps across the larval zebrafish for a growing set marker genes. data were registered Max Planck Zebrafish Brain (mapzebrain) atlas, thus covisualization expression, single-neuron tracings, expertly curated anatomical...
Abstract Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by specific combination of differentially expressed genes. Clusters neurons in transcriptomic space correspond distinct cell types some cases—for example, Caenorhabditis elegans 1 retinal ganglion cells 2–4 —have been shown share morphology function. The zebrafish optic tectum is composed spatial array that transforms visual inputs into motor outputs. Although the visuotopic map...
Abstract The advent of multimodal brain atlases promises to accelerate discoveries in neuroscience by offering silico queries cell types, connectivity and gene expression regions interest. We employed multiplexed fluorescent situ RNA hybridization chain reaction (HCR) generate maps for an initial set 200 marker genes across the larval zebrafish brain. data were registered Max Planck Zebrafish Brain (mapzebrain) atlas, thus allowing co-visualization patterns, single-neuron tracings,...
Abstract The brain is spatially organized into subdivisions, nuclei and areas, which often correspond to functional developmental units. A segmentation of regions in the form a consensus atlas facilitates mechanistic studies prerequisite for sharing information among neuroanatomists. Gene expression patterns objectively delineate boundaries between provide about their evolutionary histories. To generate detailed molecular map larval zebrafish diencephalon, we took advantage Max Planck...
Summary Neuronal phenotypic traits such as morphology, connectivity, and function are dictated, to a large extent, by specific combination of differentially expressed genes. Clusters neurons in transcriptomic space correspond distinct cell types some cases (e. g., C. elegans 1 retinal ganglion cells 2–4 ) have been shown share morphology function. The zebrafish optic tectum is composed spatial array that transforms visual inputs into motor outputs. While the visuotopic map continuous,...