A5016578076- Zebrafish Biomedical Research Applications
- Neural dynamics and brain function
- Retinal Development and Disorders
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Single-cell and spatial transcriptomics
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Biomimetic flight and propulsion mechanisms
- Gene Regulatory Network Analysis
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Neuroscience and Neural Engineering
- Animal Behavior and Welfare Studies
- Olfactory and Sensory Function Studies
- Wildlife Ecology and Conservation
Max Planck Institute for Biological Intelligence
2025
Max Planck Institute of Neurobiology
2014-2022
University of California, San Francisco
2014-2017
Zebrafish larvae show characteristic prey capture behavior in response to small moving objects. The neural mechanism used recognize objects as remains largely unknown. We devised a machine learning classification system quantify hunting kinematics semi-restrained animals exposed range of virtual stimuli. Two-photon calcium imaging revealed visual area, AF7, that was activated specifically by the optimal stimulus. This pretectal region is innervated two types retinal ganglion cells, which...
Abstract Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by specific combination of differentially expressed genes. Clusters neurons in transcriptomic space correspond distinct cell types some cases—for example, Caenorhabditis elegans 1 retinal ganglion cells 2–4 —have been shown share morphology function. The zebrafish optic tectum is composed spatial array that transforms visual inputs into motor outputs. Although the visuotopic map...
Abstract Social affiliation emerges from individual-level behavioural rules that are driven by conspecific signals 1–5 . Long-distance attraction and short-distance repulsion, for example, jointly set a preferred interanimal distance in swarms 6–8 However, little is known about their perceptual mechanisms executive neural circuits 3 Here we trace the neuronal response to self-like biological motion 9,10 , visual trigger developing zebrafish 2,11 Unbiased activity mapping targeted volumetric...
Abstract The zebrafish is increasingly being employed as an experimental platform to model neuropsychiatric diseases and screen for novel neuro-active compounds. While the superb genetic optical access that this system offers has long been recognized, these features have not fully exploited investigate disease mechanisms possible therapeutic interventions. Here we introduce a light-sheet imaging graph-theoretical analysis pipeline determine effects of known or suspected antidepressant...
Visual objects naturally compete for the brain’s attention, and selecting just one of them a behavioural response is often crucial animal’s survival 1 . The neural correlate such stimulus prioritisation might take form saliency map by which responses to target are enhanced relative distractors in other parts visual field 2 Single-cell consistent with this type computation have been observed tectum primates, birds, turtles lamprey 2–7 However, exact circuit implementation has remained...
Abstract Animals build behavioral sequences out of simple stereotyped actions. A comprehensive characterization these actions and the rules underlying their temporal organization is necessary to understand sensorimotor transformations performed by brain. Here, we use unsupervised methods study in zebrafish larvae. Generating a map swim bouts, reveal that fish modulate tail movements along continuum. We cluster bouts share common kinematic features contribute similar into seven modules....
Summary Neuronal phenotypic traits such as morphology, connectivity, and function are dictated, to a large extent, by specific combination of differentially expressed genes. Clusters neurons in transcriptomic space correspond distinct cell types some cases (e. g., C. elegans 1 retinal ganglion cells 2–4 ) have been shown share morphology function. The zebrafish optic tectum is composed spatial array that transforms visual inputs into motor outputs. While the visuotopic map continuous,...