A5089214722- Retinal Development and Disorders
- Single-cell and spatial transcriptomics
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Parasites and Host Interactions
- Cell Image Analysis Techniques
- Silk-based biomaterials and applications
- Travel-related health issues
- Insect Resistance and Genetics
- Hepatitis Viruses Studies and Epidemiology
- Advanced Fluorescence Microscopy Techniques
- Olfactory and Sensory Function Studies
- Viral Infectious Diseases and Gene Expression in Insects
Max Planck Institute of Neurobiology
2017-2024
Max Planck Institute for Biological Intelligence
2023-2024
University of Washington
2023
Washington University in St. Louis
2023
Harvard University Press
2023
Harvard University
2023
University of Sussex
2023
Technical University of Munich
2023
RWTH Aachen University
2023
Max Planck Institute of Biochemistry
2023
Abstract The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs 1 . Retinal cell types may have evolved to accommodate these varied needs, but this has not been systematically studied. Here we generated and integrated single-cell transcriptomic atlases from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a bird, reptile, teleost fish lamprey. We found high molecular conservation...
Abstract Genetic access to small, reproducible sets of neurons is key an understanding the functional wiring brain. Here we report generation a new Gal4- and Cre-driver resource for zebrafish neurobiology. Candidate genes, including cell type-specific transcription factors, neurotransmitter-synthesizing enzymes neuropeptides, were selected according their expression patterns in small unique subsets from diverse brain regions. BAC recombineering, followed by Tol2 transgenesis, was used...
The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not been systematically studied. Here, we generated and integrated single-cell transcriptomic atlases from 17 species: humans, two non-human primates, four rodents, three ungulates, opossum, ferret, tree shrew, a teleost fish, bird, reptile lamprey. Molecular...
Vertebrates rely on rod photoreceptors for vision in low-light conditions
The beetle Tribolium castaneum has increasingly become a powerful model for comparative research on insect development. One recent resource is collection of piggyBac transposon-based enhancer trap lines. Here, we provide detailed analysis three selected lines and demonstrate their value investigations in the second half embryogenesis, which thus far lagged behind early stages. Two lines, G12424 KT650, show enhanced green fluorescent protein (EGFP) expression throughout extraembryonic serosal...
Visual objects naturally compete for the brain’s attention, and selecting just one of them a behavioural response is often crucial animal’s survival 1 . The neural correlate such stimulus prioritisation might take form saliency map by which responses to target are enhanced relative distractors in other parts visual field 2 Single-cell consistent with this type computation have been observed tectum primates, birds, turtles lamprey 2–7 However, exact circuit implementation has remained...
<title>Abstract</title> Vertebrates rely on rod photoreceptors for vision in low-light conditions. Mammals have a specialized downstream circuit signaling called the primary pathway, which comprises specific cell types and wiring patterns that are thought to be unique this lineage. Thus, it has been long assumed pathway evolved mammals. Here, we challenge view by demonstrating mammalian is conserved zebrafish, diverged from extant mammals ~400 million years ago. Using single-cell...
Summary Retinal ganglion cells (RGCs) form an array of feature detectors, which convey visual information to central brain regions. Characterizing RGC diversity is required understand the logic underlying functional segregation. Using single-cell transcriptomics, we systematically classified RGCs in adult and larval zebrafish, thereby identifying marker genes for at least 33 stable transient cell types. We used this dataset engineer transgenic driver lines, enabling experimental access...