A5030690482- Cellular transport and secretion
- Neurobiology and Insect Physiology Research
- Photodynamic Therapy Research Studies
- Olfactory and Sensory Function Studies
- Genetic Mapping and Diversity in Plants and Animals
- Immunotherapy and Immune Responses
- Acne and Rosacea Treatments and Effects
- Nanoplatforms for cancer theranostics
- bioluminescence and chemiluminescence research
- Cutaneous Melanoma Detection and Management
- Immune Response and Inflammation
- Genetic Associations and Epidemiology
- Biochemical Analysis and Sensing Techniques
- Hippo pathway signaling and YAP/TAZ
- Bioinformatics and Genomic Networks
- Nuclear Receptors and Signaling
- Migraine and Headache Studies
- Retinoids in leukemia and cellular processes
- Nonmelanoma Skin Cancer Studies
- Parkinson's Disease Mechanisms and Treatments
- Social Media in Health Education
- Pituitary Gland Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
Biofrontera (Germany)
2003-2023
Ruhr University Bochum
2003-2016
Abstract Mutations in the PARK2 gene are associated with an autosomal recessive form of juvenile parkinsonism (AR-JP). These mutations affect parkin solubility and impair its E3 ligase activity, leading to a toxic accumulation proteins within susceptible neurons that results slow but progressive neuronal degeneration cell death. Here, we report RTP801/REDD1, pro-apoptotic negative regulator survival kinases mTOR Akt, is one such substrates. We observed knockdown elevated RTP801 sympathetic...
Photosensitizer formation and epidermal penetration depth represent basic predictors of drug efficacy in dermatological Photodynamic Therapy (PDT). Different formulations application standards are used to perform PDT clinical practice.Thus, we developed a human ex vivo model suitable explore permeation skin compared 10 patients the nanoemulsion formulation (BF-200 ALA) with that 20% ALA cream frequently practice. Protoporphyrin IX (PpIX) was assessed according different durations incubation...
LED illumination systems were found to be more efficacious than broad spectrum lamps in recent phase III trials on photodynamic treatment of actinic keratosis. However, a detailed comparison the light doses emitted at appropriate spectral range and its correlation effects is thus far not available for most frequently used devices. Here, we compared emissions three different PDT with their potency inducing cell death ALA-loaded A431 cells, including new system equipped advanced LEDs matching...
Abstract Not Available Study supported by Biofrontera.