A5028647452- Helminth infection and control
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Gut microbiota and health
- Plant and Biological Electrophysiology Studies
- Genomics and Phylogenetic Studies
- Olfactory and Sensory Function Studies
- Planarian Biology and Electrostimulation
- Genetic and Kidney Cyst Diseases
- Clostridium difficile and Clostridium perfringens research
University of Illinois Urbana-Champaign
2015-2019
University of Wisconsin–Madison
2019
Howard Hughes Medical Institute
2015
Michigan State University
2014
Melanins are ubiquitous and biologically important pigments, yet the molecular mechanisms that regulate their synthesis biochemical composition not fully understood. Here we present a study supports role for serotonin in melanin planarian Schmidtea mediterranea. We characterize tryptophan hydroxylase (tph) gene, which encodes rate-limiting enzyme synthesis, demonstrate by RNA interference tph is essential production pigment cups of photoreceptors. exploit this phenotype to investigate...
Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and emergence of schistosomiasis nontropical areas indicate need for new strategies prevent It has been known several decades rotifers colonizing schistosome's snail intermediate host produce a water-soluble factor paralyzes cercariae, life cycle...
Schistosomiasis, caused by the blood fluke Schistosoma , is a devastating and widespread disease affecting more than 200 million people threatening over 700 worldwide. Treatment relies exclusively on one drug, praziquantel, for which there are concerns of emerging drug resistance has shown some limitations in mass administration programs. Efforts to develop an effective vaccine combat schistosomiasis have been unsuccessful; thus, urgent need alternative drugs better prevention strategies....
Abstract Schistosomes are parasitic flatworms that infect over 200 million people, causing the neglected tropical disease, schistosomiasis. A single drug, praziquantel, is used to treat schistosome infection. Limitations in mass drug administration programs and emergence of schistosomiasis non-tropical areas indicate need for new strategies prevent It has been known several decades rotifers colonizing schistosome’s snail intermediate host produce a water-soluble factor paralyzes cercariae,...