A5023619961- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Multiple Myeloma Research and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Silicon Carbide Semiconductor Technologies
- Psychoanalysis and Psychopathology Research
- Immune Cell Function and Interaction
- Nanowire Synthesis and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- T-cell and Retrovirus Studies
- French Urban and Social Studies
- Cutaneous lymphoproliferative disorders research
- Lung Cancer Research Studies
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Health, Medicine and Society
- Phytochemical compounds biological activities
- Virus-based gene therapy research
- Social Sciences and Governance
- Social Policies and Family
- Multiculturalism, Politics, Migration, Gender
- Biomedical Ethics and Regulation
- Historical and Scientific Studies
Centre Hospitalier Universitaire de Lille
2020-2025
Lille’s Cardiology Hospital
2023-2024
Fred Hutch Cancer Center
2021-2023
Université de Lille
2022
Hôpital Claude Huriez
2020
Sage (United Kingdom)
2018-2019
Abstract Therapy-related myeloid neoplasms (t-MN), including myelodysplastic (t-MDS) and acute leukemia (t-AML), have emerged as significant late complications after CAR T cell therapy. We retrospectively analyzed 539 patients with B lymphoma treated CD19 directed therapy across four French centers. Cumulative incidences of t-MN was estimated relapse or death competing risk. Univariate propensity score matching (PSM) analyses were conducted to assess risk factors age the number prior...
The recent emergence of anti-B-cell maturation antigen (BCMA) therapies holds great promise in multiple myeloma (MM). These include chimeric receptor (CAR) T cells, bispecific antibodies, and antibody-drug conjugates. Their development clinical trials further approval are changing the strategy for treating MM. Considering that a cure has not been reached, central question coming years will be possibility using these sequentially. Here, we report 2 cases serial use anti-BCMA with parallel...
More than half of the patients treated with CD19-targeted chimeric antigen receptor (CAR) T-cell immunotherapy for large B-cell lymphoma (LBCL) do not achieve durable remission, which may be partly due to PD-1/PD-L1-associated CAR dysfunction. We report data from a phase 1 clinical trial (NCT02706405), in adults LBCL were autologous CD19 T cells (JCAR014) combined escalating doses anti-PD-L1 monoclonal antibody, durvalumab, starting either before or after infusion. The addition durvalumab...
Mycosis fungoides (MF) is the most prevalent primary cutaneous T-cell lymphoma, with an indolent or aggressive course and poor survival. The pathogenesis of MF remains unclear, prognostic factors in early stages are not well established. Here, we characterized recurrent genomic alterations using whole-exome sequencing 67 samples from 48 patients Lille University Hospital (France), including 18 sequential drawn across malignancy. Genomic data were analyzed on Broad Institute's Terra...
(R,R′)-4′-Methoxy-1-naphthylfenoterol (MNF) promotes growth inhibition and apoptosis of human HepG2 hepatocarcinoma cells via cannabinoid receptor (CBR) activation. The synthetic CB1R inverse agonist, AM251, has been shown to block the anti-mitogenic effect MNF in these cells; however, AM251 is also an agonist recently deorphanized, lipid-sensing receptor, GPR55, whose upregulation contributes carcinogenesis. Here, we investigated role GPR55 signaling PANC-1 cancer cell lines culture by...
Pour pouvoir rencontrer les adolescents accueillis au sein d’un itep , un professeur de sport, moniteur boxe et une psychologue ont allié leurs compétences créé atelier à visée thérapeutique avec la française pour médiation. Au vu des troubles que présentent ces adolescents, cadre rigoureux a été pensé autour espaces temporalité notamment. Le sport le corps sont envisagés comme support du soin psychique pensée. bilan cette expérience novatrice est globalement encourageant laisse entrevoir...