A5005249211- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Click Chemistry and Applications
- Phytochemistry and Bioactive Compounds
- Synthesis and biological activity
- Biological Activity of Diterpenoids and Biflavonoids
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Characterization of Pyrroles
- Chemical Synthesis and Analysis
Palacký University Olomouc
2014-2022
Institute of Molecular and Translational Medicine
2018-2022
Faculty (United Kingdom)
2018
University Hospital Olomouc
2018
Abstract This Focus Review summarizes recent advances in the synthesis of betulinic acid derivatives with modified A‐rings. It also focuses on their application as potential therapeutic agents for treatment cancer and other diseases. Betulinic (BA) exhibits therapeutically interesting biological properties, including antitumor, anti‐HIV, antiprotozoal, hepato‐ or nephroprotective activity; however, its clinical use has been severely limited by higher IC 50 value worse pharmacological...
Abstract A total of 41 new triterpenoids were prepared from allobetulone, methyl betulonate, oleanonate, and oleanonic acid to study their influence on cancer cells. Each 3‐oxotriterpene was brominated at C2 substituted with thiocyanate; subsequent cyclization the appropriate ammonium salts gave N‐substituted thiazoles. All compounds tested for in vitro cytotoxic activity eight cell lines two non‐cancer fibroblasts. 2‐Bromoallobetulone ( 2 b ) 2‐bromobetulonate 3 ), 2‐bromooleanonic 5...
A set of fifteen triterpenoid pyrazines and pyridines was prepared from parent 3-oxoderivatives (betulonic acid, dihydrobetulonic oleanonic moronic ursonic heterobetulonic allobetulone). Cytotoxicity all compounds tested in eight cancer two non-cancer cell lines. Evaluation the structure-activity relationships revealed that core determined whether final molecule is active or not, while heterocycle able to increase activity modulate specificity. Five (1b, 1c, 2b, 2c, 8) were found be...
An easy, good-yielding access to functionalized enantiomerically pure 1,2,3-triazole derivatives of amino acids using commercially available ketones and esters is described.