A5024829054- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- HIV/AIDS drug development and treatment
- Multicomponent Synthesis of Heterocycles
- Monoclonal and Polyclonal Antibodies Research
- Quinazolinone synthesis and applications
- Catalytic C–H Functionalization Methods
University of Mississippi
2019-2020
Bridge University
2020
KU Leuven
2015-2018
Zdravstveni centar
2015
An unprecedented approach that enables the direct and selective preparation of 1,5-disubstituted 1,2,3-triazoles from abundantly available building blocks such as primary amines, enolizable ketones 4-nitrophenyl azide a renewable source dinitrogen via an organocascade process has been developed. Furthermore, this efficient methodology also synthesis fully functionalized fused N-substituted heterocycles.
<italic>NH</italic>-1,2,3-Triazole moieties are a part of the design various biologically active compounds, pharmaceutical agents and functional materials.
Artemisinin and synthetic derivatives of dihydroartemisinin are known to possess various biological activities. Post-functionalization with triazole heterocycles has been proven lead enhanced therapeutic potential. By using our newly developed triazolization strategy, a library unexplored fused 1,5-disubstituted 1,2,3-triazole were synthesized in single step. All these compounds characterized evaluated for their anti-HIV (Human Immunodeficiency Virus) potential MT-4 cells. Interestingly;...
This TFA-catalyzed [3+2] cycloaddition of organic azides with α-fluoronitroalkenes, used as synthetic surrogates α-fluoroalkynes, provides a new route to multi-substituted fluorotriazoles broader substrate scopes and high regioselectivity.
A Gewald-four component reaction has been successfully developed for the synthesis of a series compounds containing an indole and 2-aminothiophene moiety separated by methylene spacer having anti-proliferative activity.
A practical, straightforward, and highly regioselective Zn(OAc)2-mediated method toward propargyl triazoles has been developed for the first time from commercially available enolizable ketones amine. Postfunctionalization of this triazole leads to unique N- C-linked bis-triazoles in excellent yields.
An easy, good-yielding access to functionalized enantiomerically pure 1,2,3-triazole derivatives of amino acids using commercially available ketones and esters is described.
Abstract We report the selective decomposition of bis(1,2,3‐triazoles) under rhodium(II) catalysis. The undergo an intramolecular transannulation reaction via azavinylcarbene intermediate, resulting in formation polycyclic dihydroindoles containg a fused triazole ring. magnified image
Abstract An unprecedented selective preparation of 1,5‐disubstituted 1,2,3‐triazoles from readily available primary amines, enolizable ketones and 4‐nitrophenyl azide as a renewable source dinitrogen is developed.
Here we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount trifluoroacetic acid.
Here we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount trifluoroacetic acid.
Here, we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount trifloroacetic acid. This work provides the first regioselective method to access 4-fluoro-1,5-substituted-1,2,3-triazoles.
Here, we show that 1-fluoronitroalkenes can serve as synthetic surrogates of 1-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount trifloroacetic acid. This work provides the first regioselective method to access 4-fluoro-1,5-substituted-1,2,3-triazoles.