A5051088649- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Venomous Animal Envenomation and Studies
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Reproductive System and Pregnancy
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Phenothiazines and Benzothiazines Synthesis and Activities
- Endometriosis Research and Treatment
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Urticaria and Related Conditions
- Vasculitis and related conditions
- Biochemical and Structural Characterization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- T-cell and Retrovirus Studies
- Rabies epidemiology and control
- Immune Cell Function and Interaction
National Institutes of Health
2020-2025
National Institute of Allergy and Infectious Diseases
2020-2025
Universidade de São Paulo
2014-2022
Tissue-resident macrophages (TRMs) maintain tissue homeostasis, but they can also provide a replicative niche for intracellular pathogens such as Leishmania How dermal TRMs proliferate and their M2 properties even in the strong TH1 environment of L. major infected dermis is not clear. Here, we show that, mice lacking IL-4/13 from eosinophils, shifted to proinflammatory state, numbers declined, disease was attenuated. Intravital microscopy revealed rapid infiltration eosinophils followed by...
Pattern recognition receptors (PRRs), such as Nod2, Nlrp3, Tlr2, Trl4, and Tlr9, are directly involved in type 1 diabetes (T1D) susceptibility. However, the role of cytosolic DNA sensor, AIM2, T1D pathogenesis is still unknown. Here, we demonstrate that C57BL/6 mice lacking AIM2 (AIM2−/−) prone to streptozotocin (STZ)-induced T1D, compared WT mice. The AIM2−/− phenotype associated with a greater proinflammatory response pancreatic tissues, alterations gut microbiota bacterial translocation...
Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release phagocytosis. Enhanced infiltration is associated with higher susceptibility to Leishmania infection, but effector response contribution this phenotype uncertain. Here, we show that neutrophils from susceptible BALB/c mice (B/c) produce more NETs in major than those resistant C57BL/6 (B6), which are phagocytic. The absence elastase contributes...
Visceral leishmaniasis (VL) is a vector-borne infectious disease that can be potentially fatal if left untreated. In Brazil, it caused by Leishmania infantum parasites. Blood transcriptomics allows us to assess the molecular mechanisms involved in immunopathological processes of several clinical conditions, namely, parasitic diseases. Here, we performed mRNA sequencing peripheral blood from patients with visceral during active phase and six months after successful treatment, when were...
In murine models of visceral leishmaniasis (VL), parasitization resident Kupffer cells (resKCs) is responsible for early growth
Bushmasters (Lachesis spp) and lancehead vipers (Bothrops are two of the most dangerous snakes found in Latin America. Victims envenoming by these require urgent administration antivenom. Here, we report identification a small set broadly neutralizing human monoclonal single-chain variable fragment (scFv) antibodies targeting key phospholipases A2 from Lachesis Bothrops spp using phage display technology demonstrate their vitro efficacy hemolysis assay.
Abstract Tissue-resident macrophages (TRMs) maintain tissue homeostasis, but they can also provide a replicative niche for intracellular pathogens such as Leishmania. How dermal TRMs proliferate and their M2 properties even in the strong TH1 environment of L. major infected dermis is not clear. Here, we show that mice lacking IL-4/IL-13 from eosinophils, shifted to pro-inflammatory state, numbers declined, disease was attenuated. Intravital microscopy revealed rapid infiltration eosinophils...
Abstract Visceral leishmaniasis (VL) is a potentially fatal disease transmitted by sand fly bites and caused Leishmania (L. donovani/L. infantum) protozoa. Kupffer cells (KCs) are the liver embryonic resident macrophages (emKCs), characterized Clec4f Tim4 expression their sessile behavior within sinusoids. KCs maintain numbers via self-proliferation during homeostasis but can be replaced monocyte-derived (moKCs) inflammation. In murine VL model, important for both initial parasite growth...