A5048675389- Evolution and Genetic Dynamics
- Regional Development and Management Studies
- Evolutionary Game Theory and Cooperation
- Environmental Science and Water Management
- Gut microbiota and health
- Mathematical and Theoretical Epidemiology and Ecology Models
- Antibiotic Resistance in Bacteria
- Cruise Tourism Development and Management
- Microbial Community Ecology and Physiology
- Pharmacogenetics and Drug Metabolism
- Water resources management and optimization
- Antibiotics Pharmacokinetics and Efficacy
- Bacteriophages and microbial interactions
- Microbial Metabolic Engineering and Bioproduction
- Education, Psychology, and Social Research
- Zoonotic diseases and public health
- Integrated Water Resources Management
- Water Quality and Pollution Assessment
- Water-Energy-Food Nexus Studies
- Plant Virus Research Studies
- Economic and Environmental Valuation
- Mycorrhizal Fungi and Plant Interactions
- Bacterial Identification and Susceptibility Testing
- Plant and animal studies
- Water Quality Monitoring Technologies
University of Exeter
2016-2025
Living Systems (United States)
2023
Ministry of Environmental Protection and Energy
2020-2021
Polytechnic of Rijeka
2019
University of Rijeka
2019
Hispanics in Philanthropy
2011-2016
University of Amsterdam
2016
Croatian Chamber of Economy
2016
Imperial College London
2005-2011
Alphabet (United States)
2010
Is a group best off if everyone co-operates? Theory often considers this to be so (e.g. the "conspiracy of doves"), understanding underpinning social and economic policy. We observe, however, that after competition between "cheat" "co-operator" strains yeast, population fitness is maximized under co-existence. To address whether might just peculiarity our experimental system or result with broader applicability, we assemble, benchmark, dissect, test systems model. This reveals conditions...
We need to find ways of enhancing the potency existing antibiotics, and, with this in mind, we begin an unusual question: how low can antibiotic dosages be and yet bacterial clearance still observed? Seeking optimise simultaneous use two minimal dose at which is observed vitro experimental model treatment as a criterion distinguish best worst treatments bacterium, Escherichia coli. Our aim compare combination consisting synergistic antibiotics so-called sequential choice administer change...
Ecology Letters (2010) 13: 1073–1084 Abstract Trade‐offs have been put forward as essential to the generation and maintenance of diversity. However, variation in trade‐offs is often determined at molecular level, outside scope conventional ecological inquiry. In this study, we propose that understanding intracellular basis for microbial systems can aid predicting interpreting patterns First, show how laboratory experiments mathematical models unveiled hidden mechanisms underlying key...
Although polymicrobial infections, caused by combinations of viruses, bacteria, fungi and parasites, are being recognised with increasing frequency, little is known about the occurrence within-species diversity in bacterial infections molecular evolutionary bases this diversity. We used multiple approaches to study genomic phenotypic among 226 Escherichia coli isolates from deep closed visceral occurring 19 patients. observed variability same site within 11 This was two types, as patients...
Trade-offs are thought to arise from inevitable, biophysical limitations that prevent organisms optimizing multiple traits simultaneously. A leading explanation for biodiversity maintenance is a theory if the shape, or geometry, of trade-off right, then species can coexist. Testing this theory, however, difficult as trait data usually too noisy discern trade-offs necessary not observed in vivo. To address this, we infer geometry directly mechanisms cause trade-offs, deriving two by studying...
ABSTRACT The amount of natural resources in the Earth’s environment is flux, which can trigger catastrophic collapses ecosystems. How populations survive under nutrient-poor conditions a central question ecology. Curiously, some bacteria persist for long time environments. Although this survival may be accomplished through cell death and recycling dead cells, importance these processes mechanisms underlying have not been quantitated. Here, we use microbial laboratory experiments mathematical...
Abstract Antibiotic resistance represents a growing medical concern where raw, clinical datasets are under-exploited as means to track the scale of problem. We therefore sought patterns antibiotic in Antimicrobial Testing Leadership and Surveillance (ATLAS) database. ATLAS holds 6.5M minimal inhibitory concentrations (MICs) for 3,919 pathogen-antibiotic pairs isolated from 633k patients 70 countries between 2004 2017. show most form coherent, although not stationary, timeseries whose...
Many organisms live in predictable environments with periodic variation growth condition. Adaptation to these conditions can lead loss of nonessential functions, which could be maladaptive new environments. Alternatively, living a environment allow populations accumulate cryptic genetic that may have no fitness benefit condition, but facilitate adaptation However, how processes together shape growing remains unclear. Through laboratory evolution experiments yeast, we show grown nutrient-rich...
Abstract Understanding the evolution of microbial diversity is an important and current problem in evolutionary ecology. In this paper, we investigated role two established biochemical trade‐offs diversification using a model that connects ecological processes with fundamental aspects biochemistry. The are as follows:(1) trade‐off between rate affinity substrate transport; (2) yield ATP production. Our shows these can drive under simplest possible conditions: homogeneous environment...
Cross-feeding, a relationship wherein one organism consumes metabolites excreted by another, is ubiquitous feature of natural and clinically-relevant microbial communities could be key factor promoting diversity in extreme and/or nutrient-poor environments. However, it remains unclear how readily cross-feeding interactions form, therefore our ability to predict their emergence limited. In this paper we developed mathematical model parameterized using data from the biochemistry ecology an E....
Antibiotics, by definition, reduce bacterial growth rates in optimal culture conditions; however, the real-world environments bacteria inhabit see rapid punctuated periods of low nutrient availability. How antibiotics mediate population decline during these is poorly understood. Bacteria cannot optimize for all environmental conditions because a growth-longevity tradeoff predicts faster results decline, and since bacteriostatic slow growth, they should also longevity. We quantify how...
Developing mathematical models to accurately predict microbial growth dynamics remains a key challenge in ecology, evolution, biotechnology, and public health. To reproduce grow, microbes need take up essential nutrients from the environment, classically assume that nutrient uptake rate is saturating function of concentration. In nature, experience different levels availability at all environmental scales, yet parameters shaping are commonly estimated for single initial This hampers...
Existing theory, empirical, clinical and field research all predict that reducing the virulence of individuals within a pathogen population will reduce overall virulence, rendering disease less severe. Here, we show this seemingly successful management strategy can fail with devastating consequences for infected hosts. We deploy cooperation theory novel synthetic system involving rice blast fungus Magnaporthe oryzae. In vivo infections demonstrate M. oryzae is enhanced, quite paradoxically,...
Abstract Viruses that infect bacteria, known as bacteriophages or phages, are the most prevalent entities on Earth. Their genetic diversity in nature is well documented, and members of divergent lineages can be found sharing same ecological niche. This viral influenced by a number factors, including productivity, spatial structuring environment, host-range trade-offs. Rapid evolution also to promote buffering systems from extinction. There is, however, little about impact coevolution...