Methotrexate (MTX), used in the treatment of cancerous patients, causes toxicity different organs body. This study rosmarinic acid (RA) is as an antioxidant on nephrotoxicity and hepatotoxicity induced by MTX.Rats (n = 32) were divided into four groups: sham; MTX; 100 mg\kg RA + 200 mg/kg MTX. The amount MTX was 20 mg/kg. 24 hours after injection last dose MTX, blood samples kidneys liver rats studied. aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP), urea, serum creatinine...

Abstract Introduction Autism spectrum disorder is a developmental that can affect sensory‐motor behaviors in the valproic acid (Val) rodent model of autism. Although whisker deprivation (WD) induces plastic changes cortical neurons, tactile stimulation (TS) during neonatal period may reverse it. Here, we investigate interaction effects TS and WD on behavioral histologic features barrel cortex neurons juvenile Val‐treated. Methods Control (CTL, CTL–TS, CTL–WD, CTL–TS–WD groups) Val‐treated...

Background: Renal ischemia-reperfusion (RIR) induces kidney tissue damage by increasing oxidative stress, inflammation, and apoptosis. Objectives: This study investigated the protective effects of thyme essential oil (TEO) in mitigating stress using an RIR model. Methods: Rats were randomly assigned to four groups (n = 8): (1) Sham, (2) IR, (3) IR+TEO, (4) TEO. The TEO was administered at a dose 0.5 mL/kg once daily for seven days before IR surgery. ischemia induced clamping pedicle 45...

Cisplatin is a powerful chemotherapeutic drug mainly used in the treatment of solid tumors. Aggregation renal proximal tubule cells causes nephrotoxicity and failure. Investigations showed as Cisplatin's dose-limiting side effect. One toxicity mechanisms generation reactive oxygen species, which leads to oxidative stress damage. The purpose this study was evaluation modulating effects Gallic acid on Cisplatin-induced variations including Caspase-3 Clusterin expression histopathological...

Hepatic encephalopathy (HE) is a serious neurological syndrome which caused by acute and chronic liver diseases. In this study, the effect of gallic acid (GA) as an activator AMP-activated protein kinase (AMPK) on memory anxiety-like behaviors in rats with HE bile duct ligation (BDL) was investigated.The were randomly divided into following eight groups (n=7): sham; BDL; BDL+GA 20 mg/kg; 30 sham+dorsomorphin or compound C (CC) (as AMPK inhibitors); BDL+CC; mg/kg+CC; mg/kg+CC. The received GA...

Introduction: Glutathione (GSH) protects the tissue and cell from oxidative injury. Objectives: In current study, we investigated possible effects of GSH on liver markers, stress inflammatory indices in rat with renal ischemia reperfusion (RIR) Materials Methods: Twenty-four adult male Wistar rats were divided into 3 groups (n=8). Group I (the control group), group II RIR group) received saline (0.25 mL/d, intraperitoneally; i.p.), III as that (100 mg/kg/d, i.p.). The treatment or began...

Background: Nephrotoxicity is one of the most important side effects use gentamicin sulphate (GS) resulted in reactive oxygen species generation. Antioxidant compounds played effective roles reduction renal injuries caused by using gentamicin. Carvacrol a strong antioxidant compound. Objectives: The aim this study to explore effect carvacrol inhibition lesions gentamicin-induced nephrotoxicity. Materials and Methods: In experimental study, 32 male mature Sprague-Dawley rats were divided into...

Liver damage occurs following renal ischemia-reperfusion (RIR) that can cause inflammation and inflammatory cytokines activated after kidney injury. In this study, thyme essential oil (TE) with antioxidant anti-inflammatory properties was used to reduce liver induced by IR. 32 male rats were randomly divided into 4 equal groups: (1) control, (2) RIR, (3) RIR+TE, (4) TE. Rats received TE as a pretreatment at dose of 0.5 ml/kg for one week. Then, under anesthesia 45 minutes ischemia, the...

Disturbance in the production and excretion of bile acid causes cholestatic liver disease. Liver cirrhosis is a disease that occurs if cholestasis continues. This study evaluated protective effect gallic (GA) on damage caused by biliary cirrhosis. Rats were randomly divided into 4 groups, each with 8 subjects: 1) control, 2) BDL, 3) BDL + GA 20, 4) 30. The rats anesthetized 28 days after followed collecting their blood excising liver. Their serum was used to measure enzymes, for biochemical...

Background/Aim: B19 virus (B19V) is a single-strand DNA that has specific tropism to erythroid progenitor cells (EPCs). The enters the via P antigen and coreceptors induces infection cell apoptosis. GATA1 high expression in EPC critical transcription factor for development differentiation. As human EPCs are main target of have GATA-1 as factor, aim this study was investigate effect cotransfection with B19V genome on viral mRNAs HEK293 nonpermissive line had no mRNA GATA-1. Methods: were...

Background:Troxerutin has antioxidant and anti-inflammatory properties in this study, its effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. Methods:In 64 male rats were randomly divided into 8 groups as follows: 1- IR2: ischemia (3 hours) reperfusion (2 days), 2- Trox+IR2: 3- IR7: (7 4- Trox+IR7: 5- IR14: (14 6- Trox+IR14: 7- IR28: (28 8- Trox+IR28: days). The received 150 mg/kg troxerutin one injection (single dose). After...

Background and Aim: The effect of Olive leaf extract (OLE) as a natural antioxidant was investigated on renal liver enzyme activities, after ischemia-reperfusion (IR) in rat model. Materials Methods: Forty male rats divided into 5 groups: Sham (no IR), 3 OLE+IR groups (25mg/kg, 50mg/kg 100mg/kg oral OLE once daily for 2 weeks, prior to IR) water+IR group (oral gavage water IR). In the last 4 groups, both pedicles clamped 45 minutes followed by 24 hours reperfusion. Clearance creatinine...

Gentamicin leads to kidney failure by producing free radicals and inflammation in renal tissue. Cineole as a terpenoid has antioxidant properties. Antioxidants can play an effective role preserving the oxidant-antioxidant balance. Hence, this study investigated effects of cineole on acute injury (AKI) function recovery following gentamicin administration rats.36 male Wistar rats were randomly divided into 6 equal groups; healthy control, gentamicin, DMSO carriers, 50, 100, vitamin E. After...

Introduction: Liver is a vital organ and one of its functions to release the harmful materials from body. Gentamicin an aminoglycoside used treat gram-negative bacteria infections, though it causes renal liver injuries. Antioxidants play effective roles in decreasing gentamicin-induced L-glutamine has antioxidant properties decrease Methods: In this study, thirty two wistar rats were randomly divided into four groups eight as follows: 1) control group, 2) gentamicin, 100 mg/kg for 12 days,...

Introduction: Camphor is a natural antioxidant with anti-inflammatory and tissue repair properties. Nephrotoxicity the most important side effect of gentamicin (GEM) administration. Therefore, investigating antioxidants can resolve this complication. Objectives: We aimed to assay camphor on biochemical factors gene expression enzymes (catalase [CAT], glutathione peroxidase [GPX]) inflammatory markers (tumor necrosis factor-alpha [TNF-α], nuclear factor kappa-B [NF-κB], interleukine-6...

Oleuropein (OP) is a phenolic compound in olives. OP possesses potent antioxidant activity and an extensive spectrum of other pharmacological properties, including antiviral, anti-inflammatory, antimicrobial activities. This study investigated the effects on neural injuries caused by bile duct ligation (BDL) male mice. The mice were randomly allocated to three groups: sham, BDL, BDL + OP. Neurobehavioral tests histological biochemical evaluations accomplished assess cerebral damage. results...