A5064692958- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- Blood disorders and treatments
- interferon and immune responses
- Chemical Reactions and Isotopes
- Spondyloarthritis Studies and Treatments
- Eosinophilic Esophagitis
- Renal and related cancers
- Osteomyelitis and Bone Disorders Research
- Caveolin-1 and cellular processes
- Autoimmune and Inflammatory Disorders Research
- Structural Integrity and Reliability Analysis
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Gout, Hyperuricemia, Uric Acid
- Pediatric Urology and Nephrology Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Peking Union Medical College Hospital
2022-2025
Ministry of Education of the People's Republic of China
2022-2024
National Clinical Research
2022-2024
China Medical University
2018
Sinopec (China)
2012
Abstract Background and objectives The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with nucleotide-binding oligomerization domain containing 2 ( NOD2 ) gene variants. Methods RNA sequencing analyses were used to detect transcriptomic profile changes. Immunoblot immunohistochemistry examine NOD2-mediated inflammatory signaling pathways ELISA was cytokines. Results Transcriptome analysis YAOS revealed NOD-like receptor pathway...
Abstract Backgrounds Undifferentiated or undefined systemic autoinflammatory disease (uSAID) encompasses a group of rare, heterogeneous diseases characterized by the features well-defined (SAIDs), but lacking diagnostic phenotypes genetic confirmation. We aimed to describe phenotypes, genotypes and treatment responses Chinese adult patients with uSAID. Methods The final diagnosis uSAID was reached in 61 patients, whose organ-specific inflammation compared three subgroups were identified...
Systemic autoinflammatory diseases (SAIDs) are a group of rare characterized by recurrent or continuous inflammation, typically accompanied genetic variants. Good responses to anti-TNF therapy were observed in SAIDs patients. However, the mechanisms underlying disease flare and response TNF blocking have not been fully elucidated. Here, single-cell RNA sequencing technology was used describe transcriptomic profile PBMCs PMNs two SAID patients both before after treatment. Interferon involved...
In recent years, the coal chemical industry project which can replace petrochemical products is an investment hot spot. The Syngas-purification Unit a main part of industry. Its role is: purify syngas obtained from gasification reaction (absorb hydrogen sulfide and carbon dioxide). Yet, there no research summary about corrosion, failure mechanism risk level this unit. paper, syngas-purification equipment Sinopec Qilu Corporation were quantified by RBI analysis, investigated corrosion...
Background and Objectives: In this study, the spatial courses of connecting tubule (CNT) nephron from different depth cortex collecting duct (CD) in mouse kidney was established with aid three-dimensional visualization technology. Subjects Methods: Kidneys three C57/BL/6J mice were removed after perfusion fixation. The tissue blocks cut perpendicular to longitudinal axis embedded Epon-812. A total 2000, 2.5-μm-thick consecutive sections obtained renal capsule papilla. After acquiring...
Abstract Background: NLRP3 -associated autoinflammatory disease ( -AID) is a spectrum of autosomal dominant inherited diseases associated with gene mutations. Reports Chinese -AID cases are limited to date. In the present study, we aim describe phenotype and genotype cohort adult patients. Methods: This single-center study included sixteen patients diagnosed at Department Rheumatology, Peking Union Medical College Hospital between July 2015 September 2021. Whole-exome sequencing using...
Abstract Systemic autoinflammatory diseases (SAIDs) are a group of rare characterized by recurrent or continuous inflammation, typically accompanied genetic variants. Good responses to anti-TNFα therapy were observed in SAIDs patients. However, the mechanisms underlying disease flare and response TNFα blocking have not been fully elucidated. Here, we use single-cell RNA sequencing technology describe transcriptomic profile PBMCs PMNs patients both before after treatment. We found that...