A5040736435- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Synthesis and Properties of Aromatic Compounds
- Organoboron and organosilicon chemistry
- Magnetism in coordination complexes
- Advanced NMR Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Hydrogels: synthesis, properties, applications
- Metal-Catalyzed Oxygenation Mechanisms
- MRI in cancer diagnosis
- Metal complexes synthesis and properties
- Oxidative Organic Chemistry Reactions
- Carbon dioxide utilization in catalysis
- Eicosanoids and Hypertension Pharmacology
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Advanced Polymer Synthesis and Characterization
- DNA and Nucleic Acid Chemistry
Charles University
2018-2024
Abstract Planar chiral [2.2]paracyclophanes consist of two functionalized benzene rings connected by ethylene bridges. These organic compounds have a wide range applications in asymmetric synthesis, as both ligands and catalysts, materials science, polymers, energy dyes. However, these molecules can only be accessed enantiomer separation via (a) time-consuming separations (b) kinetic resolution approaches, often with limited substrate scope, yielding enantiomers. Here, we report simple,...
Complexes of the title ligand with selected paramagnetic first-row transition metal ions exhibit short longitudinal relaxation times ( T 1 ) 19 F nuclei and high stabilities, promising for potential use as effective MRI contrast agents.
19F MRI requires biocompatible and non-toxic soluble contrast agents with high fluorine content suitable relaxation times. Probes based on a DOTP chelate 12 magnetically equivalent atoms (DOTP-tfe) lanthanide(III) ion shortening the times were prepared tested. Complexes of DOTP-tfe trivalent paramagnetic Ce, Dy, Ho, Tm, Yb ions synthetized characterized. determined compared to those La complex empty ligand. In vitro in vivo was performed at 4.7 T. strongly depended chelated ion. T1 ranged...
Planar chiral [2.2]paracyclophanes consist of two functionalized benzene rings connected by ethylene bridges. These organic compounds have a wide range applications in asymmetric synthesis, as both ligands and catalysts, materials science, polymers, energy dyes. However, these molecules can only be accessed enantiomer separation via a) time-consuming separations b) kinetic resolution approaches, often with limited substrate scope, yielding enantiomers. Here, we report simple, efficient,...
A new hexadentate 1,4,7-triazacyclononane-based ligand bearing three coordinating methylene-(2,2,2-trifluoroethyl)phosphinate pendant arms was synthesized and its coordination behaviour towards selected divalent (Mg
Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broadening the possibilities of commonly used proton MRI. Despite potential 19F MRI, an ideal tracer paving way toward entry this method into common medical practice is yet to be developed. In study, we report on series polymeric systems based thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), polymer considered for The described are designed BAB triblock copolymers, where B...
We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines. The first step is triflic acid-promoted decarboxylation adamantane carbamates, which causes rearrangement framework to form iminium salts, are reduced amines in second separate step.
A series of Cu(II) complexes with cyclam-based ligands containing two N-(2,2,2-trifluoroethyl)-aminoalkyl pendant arms in 1,8-positions (L1: 1,2-ethylene spacer, L2: 1,3-propylene spacer; L3: 1,4-butylene spacer) was studied respect to potential use as contrast agents for 19F magnetic resonance imaging (MRI). number structures the well several organic precursors were determined by single-crystal X-ray diffraction analysis. Geometric parameters (especially distances between fluorine atoms and...