A5070757792- Sepsis Diagnosis and Treatment
- Vitamin D Research Studies
- Alzheimer's disease research and treatments
- Hemodynamic Monitoring and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Neonatal and Maternal Infections
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Multiple Sclerosis Research Studies
- Amyotrophic Lateral Sclerosis Research
- Long-Term Effects of COVID-19
- Diabetes Treatment and Management
- Pharmacological Effects and Toxicity Studies
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Adipokines, Inflammation, and Metabolic Diseases
University of Palermo
2016-2025
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2016-2022
(1) Background: The evaluation of anti-spike protein receptor-binding domain (S-RBD) antibodies represents a useful tool to estimate the individual protection against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection; (2) Methods: We evaluated anti S-RBD IgG levels by indirect chemiluminescence immunoassay on Maglumi 800 (SNIBE, California) in 2248 vaccinated subjects without previous SARS-CoV-2 infection, 91 individuals recovered from COVID-19, and 268 COVID-19 who had...
Abstract Objectives The diagnosis of sepsis in the Emergency Department (ED) is challenging and a reliable biomarker needed. current study aimed to evaluate diagnostic accuracy monocyte distribution width (MDW) for early identification ED. Methods We performed large observational including consecutive adult patients (≥18 years age) presenting ED between September November 2019, with an order complete blood count (CBC) evaluation. A total 2,215 were enrolled classified based on Sepsis-2...
Neurodegenerative disorders (NDs) represent a group of different diseases characterized by the progressive degeneration and death nervous system's cells. The diagnosis is challenging, especially in early stages, due to no specific clinical signs symptoms. In this context, laboratory medicine could support clinicians detecting differentiating NDs. Indeed, biomarkers indicate pathological mechanisms underpinning ideal biofluid for NDs cerebrospinal fluid (CSF), which has limitations, hampering...
Immunosurveillance by evaluating anti-spike protein receptor-binding domain (S-RBD) antibodies represents a useful tool to estimate the long immunity against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection. The aim of this study was evaluate kinetics antibody response in vaccine recipients. We measured anti-S-RBD IgG levels indirect chemiluminescence immunoassay on Maglumi 800 (SNIBE, California) 1013 healthy individuals naïve SARS-CoV2 infection after two and three...
In the last decades, an important role of cerebrospinal fluid (CSF) biomarkers for Alzheimer disease (AD) diagnosis has emerged. The evaluation triad consisting 42 aminoacid-long amyloid-beta peptide (Aβ42), total Tau (tTau) and phosphorylated at threonine 181 (pTau) have been recently integrated into research diagnostic criteria AD. For a long time, enzyme-linked immunosorbent assay (ELISA) represented most commonly used method measurement CSF levels. This study aimed to assess accuracy...
Monocyte distribution width has been recently proposed as a sepsis biomarker in the emergency department. The aim of this study was to assess role monocyte diagnostic intensive care unit.In prospective observational study, we included all consecutive patients admitted unit University Hospital "P. Giaccone" Palermo. Patients were classified into three groups according Sepsis-3 criteria: (1) without sepsis; (2) developing during their hospital stay; (3) with sepsis. measured at admission...
Abstract Objectives In this study, we developed and evaluated the diagnostic accuracy of Sepsis Index for early sepsis screening in Emergency Department (ED). Methods is based on combination monocyte distribution width (MDW) mean volume (MMV). Index≥1 was selected to define sepsis. We tested its an ED population stratified four groups: controls, Systemic Inflammatory Response Syndrome (SIRS), infection, sepsis, according Sepsis-2 criteria. Results Patients with displayed higher median value...