A5018043909- Genetic and Kidney Cyst Diseases
- Electrolyte and hormonal disorders
- Renal cell carcinoma treatment
- Biomedical Research and Pathophysiology
- Renal and related cancers
- MRI in cancer diagnosis
- Diet and metabolism studies
- Pneumonia and Respiratory Infections
- Trypanosoma species research and implications
- Neonatal and Maternal Infections
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Genetics and Neurodevelopmental Disorders
- Renal Diseases and Glomerulopathies
- Potassium and Related Disorders
- Ion Transport and Channel Regulation
- Blood Pressure and Hypertension Studies
- Parathyroid Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
Agostino Gemelli University Polyclinic
2019-2024
Università Cattolica del Sacro Cuore
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
University of Toronto
2023
University Health Network
2023
University of Palermo
2015
<b><i>Background/Aims:</i></b> Aim of our study was to describe the association between natremia (Na) fluctuation and hospital mortality in a general population admitted tertiary medical center. <b><i>Methods:</i></b> We performed retrospective observational cohort on patient Fondazione Policlinico A. Gemelli IRCCS Hospital January 2010 December 2014 with inclusion adult patients at least 2 Na values available normonatremic condition admission....
Tolvaptan is the first disease-modifying drug proven to slow eGFR decline in high-risk patients with ADPKD. However, barriers from patient perspective its use real-life settings have not been systemically examined a large cohort. This was single-center, retrospective study of 523 existing or new ADPKD followed at Center for Innovative Management PKD Toronto, Ontario, between January 1, 2016 December 31, 2018. All underwent clinical assessment including total kidney volume measurements and...
Abstract Background and Aims Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited nephropathy due to mutations in PKD1 or PKD2 genes. In addition involvement, ADPKD also characterized by extrarenal manifestations including presence of cysts other organs, intracranial aneurysms, arterial hypertension, valvulopathies left ventricular hypertrophy (LVH). Cardiac abnormalities are an important cause morbidity mortality patients. Limited data on association between...
The clinical manifestations of ADPKD are related to the growth renal cysts. Renal volume has been recognised as biomarker that is able identify those patients at risk complications (hypertension and haematuria) progression End Stage Disease (ESRD). Recently, several scores have introduced predict evolution ADPKD. Mayo Clinic Group developed a classification based on measured by CT or MRI corrected for age height (Ht-TKV); this allowed predicting disease, but it not fully validated so far. In...
Background . Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic anemia, thrombocytopenia, and renal failure. Mutations in CFI gene coding for complement regulation factors THBD endothelial cell receptor thrombomodulin could predispose to the disease hypertension can trigger onset. Case Presentation A 51-year-old female patient who had received kidney transplant eighteen years ago presented with hypertensive peak hemolysis pattern. Normal ADAMTS13 levels as well...
Abstract Background and Aims Tolvaptan is the first disease-modifier therapy proven to slow eGFR decline in high-risk patients with ADPKD. However, barriers its use real-life settings have not been examined. Method Single-center, retrospective study of 523 current or new ADPKD followed at Center for Innovative Management PKD Toronto, Ontario between January 1, 2016 December 30, 2018. All had clinical assessment total kidney volume measurements; those deemed be high risk based on their Mayo...
Abstract Background and Aims Clinical management of autosomal dominant polycystic kidney disease (ADPKD) might take advantage the use new tools to predict risk progression towards end stage (ESKD). The aim this study is develop validate a model based on radiomic features function among patients with ADPKD obtained from CT scans performed for determination total volume (TKV). Method We retrospectively selected cohort 58 who underwent scan February 2020 March 2021, including 30 eGFR ≥ 60...
Abstract Background and Aims The natural history of ADPKD has been defined in numerous studies various countries genetic environmental contexts but the problem not yet studied sufficiently large Italian population. We have evolution a cohort 445 incident patients enrolled time span between 2012 2016 28 nephrological centers 3 regions central Italy. main demographic clinical characteristics this are reported below. [GRAPHICS] Method analysis was carried out on sample 296 with at least 2...